4gsu - Revision history

OCA at 12:22, 15 November 2023

OCA — Wed, 15 Nov 2023 12:22:35 GMT

←Older revision		Revision as of 12:22, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='4gsu' size='340' side='right'caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4gsu' size='340' side='right'caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4gsq\|4gsq]], [[4gsr\|4gsr]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [https://pdbe.org/4gsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [https://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [https://pdbe.org/4gsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [https://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: An~~, D R~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Han~~, B W~~]]	+	[[Category: An DR]]
-	[[Category: Im~~, H N~~]]	+	[[Category: Han BW]]
-	[[Category: Kim~~, H S~~]]	+	[[Category: Im HN]]
-	[[Category: Kim, J]]	+	[[Category: Kim HS]]
-	[[Category: Kim~~, J Y~~]]	+	[[Category: Kim J]]
-	[[Category: Kim, S J]]	+	[[Category: Kim JY]]
-	[[Category: Lee~~, J Y~~]]	+	[[Category: Kim S-J]]
-	[[Category: Min~~, H K~~]]	+	[[Category: Lee JY]]
-	[[Category: Suh~~, S W~~]]	+	[[Category: Min HK]]
-	[[Category: Yoon~~, H J~~]]	+	[[Category: Suh SW]]
-	[[Category: Yoon~~, J Y]]~~	+	[[Category: Yoon HJ]]
-	~~[[Category: D-transpeptidase]]~~	+	[[Category: Yoon JY]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:27, 9 February 2022

OCA — Wed, 09 Feb 2022 07:27:35 GMT

←Older revision		Revision as of 07:27, 9 February 2022
Line 1:		Line 1:

	==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==		==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
-	<StructureSection load='4gsu' size='340' side='right' caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4gsu' size='340' side='right'caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gsq\|4gsq]], [[4gsr\|4gsr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4gsq\|4gsq]], [[4gsr\|4gsr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [~~http~~://pdbe.org/4gsu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [https://pdbe.org/4gsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [https://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: An, D R]]		[[Category: An, D R]]
	[[Category: Han, B W]]		[[Category: Han, B W]]

OCA at 08:34, 11 August 2016

OCA — Thu, 11 Aug 2016 08:34:52 GMT

←Older revision		Revision as of 08:34, 11 August 2016
Line 1:		Line 1:
		+
	==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==		==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
	<StructureSection load='4gsu' size='340' side='right' caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4gsu' size='340' side='right' caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gsq\|4gsq]], [[4gsr\|4gsr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gsq\|4gsq]], [[4gsr\|4gsr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [http://www.ebi.ac.uk/pdbsum/4gsu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [http://pdbe.org/4gsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [http://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gsu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: An, D R]]		[[Category: An, D R]]
	[[Category: Han, B W]]		[[Category: Han, B W]]

OCA at 14:41, 5 January 2015

OCA — Mon, 05 Jan 2015 14:41:26 GMT

←Older revision		Revision as of 14:41, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4gsu\| PDB=4gsu \| SCENE= }}~~	+	==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
-	===Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains===	+	<StructureSection load='4gsu' size='340' side='right' caption='[[4gsu]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23519417}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gsq\|4gsq]], [[4gsr\|4gsr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lppS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [http://www.ebi.ac.uk/pdbsum/4gsu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Difficulty in the treatment of tuberculosis and growing drug resistance in Mycobacterium tuberculosis (Mtb) are a global health issue. Carbapenems inactivate L,D-transpeptidases; meropenem, when administered with clavulanate, showed in vivo activity against extensively drug-resistant Mtb strains. LdtMt2 (Rv2518c), one of two functional L,D-transpeptidases in Mtb, is predominantly expressed over LdtMt1 (Rv0116c). Here, the crystal structure of N-terminally truncated LdtMt2 (residues Leu131-Ala408) is reported in both ligand-free and meropenem-bound forms. The structure of meropenem-inhibited LdtMt2 provides a detailed structural view of the interactions between a carbapenem drug and Mtb L,D-transpeptidase. The structures revealed that the catalytic L,D-transpeptidase domain of LdtMt2 is preceded by a bacterial immunogloblin-like Big_5 domain and is followed by an extended C-terminal tail that interacts with both domains. Furthermore, it is shown using mass analyses that meropenem acts as a suicide inhibitor of LdtMt2. Upon acylation of the catalytic Cys354 by meropenem, the `active-site lid' undergoes a large conformational change to partially cover the active site so that the bound meropenem is accessible to the bulk solvent via three narrow paths. This work will facilitate structure-guided discovery of L,D-transpeptidase inhibitors as novel antituberculosis drugs against drug-resistant Mtb.

-	~~==About this Structure==~~	+	Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains.,Kim HS, Kim J, Im HN, Yoon JY, An DR, Yoon HJ, Kim JY, Min HK, Kim SJ, Lee JY, Han BW, Suh SW Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):420-31. doi:, 10.1107/S0907444912048998. Epub 2013 Feb 16. PMID:23519417<ref>PMID:23519417</ref>
-	~~[[4gsu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4GSU OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023519417</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: An, D R.]]	+	[[Category: An, D R]]
-	[[Category: Han, B W.]]	+	[[Category: Han, B W]]
-	[[Category: Im, H N.]]	+	[[Category: Im, H N]]
-	[[Category: Kim, H S.]]	+	[[Category: Kim, H S]]
-	[[Category: Kim, J.]]	+	[[Category: Kim, J]]
-	[[Category: Kim, J Y.]]	+	[[Category: Kim, J Y]]
-	[[Category: Kim, S J.]]	+	[[Category: Kim, S J]]
-	[[Category: Lee, J Y.]]	+	[[Category: Lee, J Y]]
-	[[Category: Min, H K.]]	+	[[Category: Min, H K]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
-	[[Category: Yoon, H J.]]	+	[[Category: Yoon, H J]]
-	[[Category: Yoon, J Y.]]	+	[[Category: Yoon, J Y]]
	[[Category: D-transpeptidase]]		[[Category: D-transpeptidase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 18:57, 7 August 2013

OCA — Wed, 07 Aug 2013 18:57:43 GMT

←Older revision		Revision as of 18:57, 7 August 2013
Line 1:		Line 1:
-	[[Image:4gsu.jpg\|left\|200px]]
-
	{{STRUCTURE_4gsu\| PDB=4gsu \| SCENE= }}		{{STRUCTURE_4gsu\| PDB=4gsu \| SCENE= }}
-
	===Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains===		===Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains===
-		+	{{ABSTRACT_PUBMED_23519417}}

	==About this Structure==		==About this Structure==
	[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA].		[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023519417</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: An, D R.]]		[[Category: An, D R.]]

OCA at 14:58, 27 February 2013

OCA — Wed, 27 Feb 2013 14:58:53 GMT

←Older revision		Revision as of 14:58, 27 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gsu.jpg\|left\|200px]]

-	~~The entry~~ 4gsu ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gsu\| PDB=4gsu \| SCENE= }}

-	~~Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An~~, D~~.R.~~, ~~Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.~~-~~J., Lee, J.Y., Han, B.W., Suh, S.W.~~	+	===Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains===

-	~~Description~~: ~~Structural basis for the inhibition of~~ Mycobacterium tuberculosis L,D~~-transpeptidase by meropenem~~, ~~a drug effective against extensively drug~~-~~resistant strains~~	+
		+	==About this Structure==
		+	[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA].
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: An, D R.]]
		+	[[Category: Han, B W.]]
		+	[[Category: Im, H N.]]
		+	[[Category: Kim, H S.]]
		+	[[Category: Kim, J.]]
		+	[[Category: Kim, J Y.]]
		+	[[Category: Kim, S J.]]
		+	[[Category: Lee, J Y.]]
		+	[[Category: Min, H K.]]
		+	[[Category: Suh, S W.]]
		+	[[Category: Yoon, H J.]]
		+	[[Category: Yoon, J Y.]]
		+	[[Category: D-transpeptidase]]
		+	[[Category: Transferase]]

OCA at 20:08, 26 September 2012

OCA — Wed, 26 Sep 2012 20:08:25 GMT

←Older revision		Revision as of 20:08, 26 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gsu is ON HOLD	+	The entry 4gsu is ON HOLD until Paper Publication

	Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An, D.R., Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.-J., Lee, J.Y., Han, B.W., Suh, S.W.		Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An, D.R., Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.-J., Lee, J.Y., Han, B.W., Suh, S.W.

	Description: Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains		Description: Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

OCA: Protected "4gsu" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:58:09 GMT

Protected "4gsu" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gsu is ON HOLD Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An, D.R., Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.-J., Lee, J.Y., Han, B.W., Suh...

OCA — Wed, 05 Sep 2012 04:58:08 GMT

New page: '''Unreleased structure''' The entry 4gsu is ON HOLD Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An, D.R., Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.-J., Lee, J.Y., Han, B.W., Suh...

New page

'''Unreleased structure'''

The entry 4gsu is ON HOLD

Authors: Kim, H.S., Kim, J., Im, H.N., Yoon, J.Y., An, D.R., Yoon, H.J., Kim, J.Y., Min, H.K., Kim, S.-J., Lee, J.Y., Han, B.W., Suh, S.W.

Description: Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains