4gt0 - Revision history

OCA at 07:15, 26 October 2022

OCA — Wed, 26 Oct 2022 07:15:56 GMT

←Older revision		Revision as of 07:15, 26 October 2022
Line 1:		Line 1:

	==Structure of dengue virus serotype 1 sE containing stem to residue 421==		==Structure of dengue virus serotype 1 sE containing stem to residue 421==
-	<StructureSection load='4gt0' size='340' side='right' caption='[[4gt0]], [[Resolution\|resolution]] 2.57Å' scene=''>	+	<StructureSection load='4gt0' size='340' side='right'caption='[[4gt0]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gt0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Den1w Den1w~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gt0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1_Nauru/West_Pac/1974 Dengue virus 1 Nauru/West Pac/1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GT0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g7t\|3g7t]], [[1ok8\|1ok8]], [[1urz\|1urz]], [[4gsx\|4gsx]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gt0 OCA], [https://pdbe.org/4gt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gt0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gt0 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11059 DEN1W])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gt0 OCA], [~~http~~://pdbe.org/4gt0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gt0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gt0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gt0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/POLG_DEN1W POLG_DEN1W]] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).	+	[https://www.uniprot.org/uniprot/POLG_DEN1W POLG_DEN1W] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Den1w~~]]	+	[[Category: Dengue virus 1 Nauru/West Pac/1974]]
-	[[Category: ~~Choi, J L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Harrison, S C~~]]	+	[[Category: Choi JL]]
-	[[Category: ~~Klein, D E~~]]	+	[[Category: Harrison SC]]
-	[[Category: ~~Viral fusion protein]]~~	+	[[Category: Klein DE]]
-	~~[[Category: Viral protein~~]]	+

OCA at 00:00, 5 August 2016

OCA — Fri, 05 Aug 2016 00:00:23 GMT

←Older revision		Revision as of 00:00, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of dengue virus serotype 1 sE containing stem to residue 421==		==Structure of dengue virus serotype 1 sE containing stem to residue 421==
	<StructureSection load='4gt0' size='340' side='right' caption='[[4gt0]], [[Resolution\|resolution]] 2.57Å' scene=''>		<StructureSection load='4gt0' size='340' side='right' caption='[[4gt0]], [[Resolution\|resolution]] 2.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dengue_virus_1_nauru/west_pac/1974 Dengue virus 1 nauru/west pac/1974~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den1w Den1w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g7t\|3g7t]], [[1ok8\|1ok8]], [[1urz\|1urz]], [[4gsx\|4gsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g7t\|3g7t]], [[1ok8\|1ok8]], [[1urz\|1urz]], [[4gsx\|4gsx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11059 ~~Dengue virus 1 Nauru/West Pac/1974~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11059 DEN1W])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4gt0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gt0 OCA], [http://pdbe.org/4gt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4gt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gt0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gt0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dengue virus 1 nauru/west pac/1974~~]]	+	[[Category: Den1w]]
	[[Category: Choi, J L]]		[[Category: Choi, J L]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 20:58, 24 December 2014

OCA — Wed, 24 Dec 2014 20:58:13 GMT

←Older revision		Revision as of 20:58, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gt0.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of dengue virus serotype 1 sE containing stem to residue 421==
		+	<StructureSection load='4gt0' size='340' side='right' caption='[[4gt0]], [[Resolution\|resolution]] 2.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1_nauru/west_pac/1974 Dengue virus 1 nauru/west pac/1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GT0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g7t\|3g7t]], [[1ok8\|1ok8]], [[1urz\|1urz]], [[4gsx\|4gsx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11059 Dengue virus 1 Nauru/West Pac/1974])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gt0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4gt0 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/POLG_DEN1W POLG_DEN1W]] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The final stages of dengue virus fusion are thought to occur when the membrane-proximal stem drives the transmembrane anchor of the viral envelope protein (E) toward the fusion loop, buried in the target cell membrane. Crystal structures of E have lacked this essential stem region. We expressed and crystallized soluble mutant forms of the dengue virus envelope protein (sE) that include portions of the juxtamembrane stem. Their structures represent late-stage fusion intermediates. The proximal part of the stem has both intra- and intermolecular interactions, so the chain "zips up" along the trimer seam. The penultimate interaction we detected involves the conserved residue F402, which has hydrophobic contacts with a conserved surface on domain II. These interactions do not require any larger-scale changes in trimer packing. The techniques for expression and crystallization of sE containing stem reported here may allow further characterization of the final stages of flavivirus fusion.

-	~~{{STRUCTURE_4gt0\| PDB=4gt0 \| SCENE= }}~~	+	Structure of a dengue virus envelope protein late-stage fusion intermediate.,Klein DE, Choi JL, Harrison SC J Virol. 2013 Feb;87(4):2287-93. doi: 10.1128/JVI.02957-12. Epub 2012 Dec 12. PMID:23236058<ref>PMID:23236058</ref>

-	~~===Structure~~ of ~~dengue virus serotype 1 sE containing stem to residue 421===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23236058}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gt0]] is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Dengue_virus_1_nauru/west_pac/1974 Dengue virus 1 nauru/west pac/1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA].	+	</StructureSection>
	[[Category: Dengue virus 1 nauru/west pac/1974]]		[[Category: Dengue virus 1 nauru/west pac/1974]]
-	[[Category: Choi, J L.]]	+	[[Category: Choi, J L]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
-	[[Category: Klein, D E.]]	+	[[Category: Klein, D E]]
	[[Category: Viral fusion protein]]		[[Category: Viral fusion protein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 12:27, 30 January 2013

OCA — Wed, 30 Jan 2013 12:27:20 GMT

←Older revision		Revision as of 12:27, 30 January 2013
Line 1:		Line 1:
-	[[Image:4gt0.~~jpg~~\|left\|200px]]	+	[[Image:4gt0.png\|left\|200px]]

	{{STRUCTURE_4gt0\| PDB=4gt0 \| SCENE= }}		{{STRUCTURE_4gt0\| PDB=4gt0 \| SCENE= }}
Line 5:		Line 5:
	===Structure of dengue virus serotype 1 sE containing stem to residue 421===		===Structure of dengue virus serotype 1 sE containing stem to residue 421===

		+	{{ABSTRACT_PUBMED_23236058}}

	==About this Structure==		==About this Structure==

OCA at 11:36, 19 December 2012

OCA — Wed, 19 Dec 2012 11:36:58 GMT

←Older revision		Revision as of 11:36, 19 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gt0.jpg\|left\|200px]]

-	~~The entry~~ 4gt0 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4gt0\| PDB=4gt0 \| SCENE= }}

-	~~Authors: Klein, D.E., Choi, J., Harrison, S.C.~~	+	===Structure of dengue virus serotype 1 sE containing stem to residue 421===

-	~~Description:~~ Structure ~~of dengue~~ virus ~~serotype~~ 1 ~~sE containing stem to residue 421~~	+
		+	==About this Structure==
		+	[[4gt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1_nauru/west_pac/1974 Dengue virus 1 nauru/west pac/1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GT0 OCA].
		+	[[Category: Dengue virus 1 nauru/west pac/1974]]
		+	[[Category: Choi, J L.]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Klein, D E.]]
		+	[[Category: Viral fusion protein]]
		+	[[Category: Viral protein]]

OCA at 13:59, 28 November 2012

OCA — Wed, 28 Nov 2012 13:59:40 GMT

←Older revision		Revision as of 13:59, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gt0 is ON HOLD	+	The entry 4gt0 is ON HOLD until Paper Publication

	Authors: Klein, D.E., Choi, J., Harrison, S.C.		Authors: Klein, D.E., Choi, J., Harrison, S.C.

	Description: Structure of dengue virus serotype 1 sE containing stem to residue 421		Description: Structure of dengue virus serotype 1 sE containing stem to residue 421

OCA at 06:54, 19 September 2012

OCA — Wed, 19 Sep 2012 06:54:07 GMT

←Older revision		Revision as of 06:54, 19 September 2012
Line 3:		Line 3:
	The entry 4gt0 is ON HOLD		The entry 4gt0 is ON HOLD

-	Authors: Klein, D.E, Choi, J, Harrison, S.C.	+	Authors: Klein, D.E., Choi, J., Harrison, S.C.

	Description: Structure of dengue virus serotype 1 sE containing stem to residue 421		Description: Structure of dengue virus serotype 1 sE containing stem to residue 421

OCA: Protected "4gt0" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:58:19 GMT

Protected "4gt0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gt0 is ON HOLD Authors: Klein, D.E, Choi, J, Harrison, S.C. Description: Structure of dengue virus serotype 1 sE containing stem to residue 421

OCA — Wed, 05 Sep 2012 04:58:18 GMT

New page: '''Unreleased structure''' The entry 4gt0 is ON HOLD Authors: Klein, D.E, Choi, J, Harrison, S.C. Description: Structure of dengue virus serotype 1 sE containing stem to residue 421

New page

'''Unreleased structure'''

The entry 4gt0 is ON HOLD

Authors: Klein, D.E, Choi, J, Harrison, S.C.

Description: Structure of dengue virus serotype 1 sE containing stem to residue 421