4gtm - Revision history

OCA at 14:00, 8 November 2023

OCA — Wed, 08 Nov 2023 14:00:58 GMT

←Older revision		Revision as of 14:00, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [https://pdbe.org/4gtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [https://www.ebi.ac.uk/pdbsum/4gtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [https://pdbe.org/4gtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [https://www.ebi.ac.uk/pdbsum/4gtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtm ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:17, 26 October 2022

OCA — Wed, 26 Oct 2022 07:17:07 GMT

←Older revision		Revision as of 07:17, 26 October 2022
Line 1:		Line 1:

	==FTase in complex with BMS analogue 11==		==FTase in complex with BMS analogue 11==
-	<StructureSection load='4gtm' size='340' side='right' caption='[[4gtm]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4gtm' size='340' side='right'caption='[[4gtm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]], [[4gtv\|4gtv]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [https://pdbe.org/4gtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [https://www.ebi.ac.uk/pdbsum/4gtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtm ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [~~http~~://pdbe.org/4gtm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gtm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	+	[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Farnesyltransferase\|Farnesyltransferase]]	+	*[[Farnesyltransferase 3D structures\|Farnesyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Protein farnesyltransferase~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Bon~~, R S~~]]	+	[[Category: Bon RS]]
-	[[Category: Goody~~, R S~~]]	+	[[Category: Goody RS]]
-	[[Category: Guo, Z]]	+	[[Category: Guo Z]]
-	[[Category: Stigter~~, E A~~]]	+	[[Category: Stigter EA]]
-	[[Category: Waldmann, H]]	+	[[Category: Waldmann H]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Protein prenylation]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 12:10, 4 August 2016

OCA — Thu, 04 Aug 2016 12:10:29 GMT

←Older revision		Revision as of 12:10, 4 August 2016
Line 1:		Line 1:
		+
	==FTase in complex with BMS analogue 11==		==FTase in complex with BMS analogue 11==
	<StructureSection load='4gtm' size='340' side='right' caption='[[4gtm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4gtm' size='340' side='right' caption='[[4gtm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]], [[4gtv\|4gtv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]], [[4gtv\|4gtv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~]), Fntb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Fntb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [http://www.ebi.ac.uk/pdbsum/4gtm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [http://pdbe.org/4gtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [http://www.ebi.ac.uk/pdbsum/4gtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gtm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Farnesyltransferase\|Farnesyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]
	[[Category: Bon, R S]]		[[Category: Bon, R S]]

OCA at 14:20, 24 December 2014

OCA — Wed, 24 Dec 2014 14:20:05 GMT

←Older revision		Revision as of 14:20, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [http://www.ebi.ac.uk/pdbsum/4gtm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [http://www.ebi.ac.uk/pdbsum/4gtm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:13, 10 December 2014

OCA — Wed, 10 Dec 2014 09:13:48 GMT

←Older revision		Revision as of 09:13, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gtm.~~jpg~~\|~~left~~\|~~200px~~]]	+	==FTase in complex with BMS analogue 11==
		+	<StructureSection load='4gtm' size='340' side='right' caption='[[4gtm]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TM:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+HEXYLCARBAMATE'>7TM</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]], [[4gtv\|4gtv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Fnta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Fntb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtm RCSB], [http://www.ebi.ac.uk/pdbsum/4gtm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the Ras superfamily of small GTPases are frequently mutated in cancer. Therefore, inhibitors have been developed to address the acitivity of these GTPases by inhibiting their prenylating enzymes FTase, GGTase I, and RabGGTase. In contrast to FTase and GGTase I, only a handful of RabGGTase inhibitors have been developed. The most active RabGGTase inhibitor known until recently was an FTase inhibitor which hit RabGGTase as an off-target. We recently reported our efforts to tune the selectivity of these inhibitors toward RabGGTase. Here we describe an extended set of selective inhibitors. The requirements for selective RabGGTase inhibitors are described in detail, guided by multiple crystal structures. In order to relate in vitro and cellular activity, a high-throughput assay system to detect the attachment of [(3)H]geranylgeranyl groups to Rab was used. Selective RabGGTase inhibition allows the establishment of novel drug discovery programs aimed at the development of anticancer therapeutics.

-	~~{{STRUCTURE_4gtm\| PDB=4gtm \| SCENE= }}~~	+	Development of Selective, Potent RabGGTase Inhibitors.,Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s. Epub 2012 Oct 3. PMID:22963166<ref>PMID:22963166</ref>

-	~~===FTase in complex with BMS analogue 11===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22963166}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4gtm]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA].~~	+	</StructureSection>
	[[Category: Protein farnesyltransferase]]		[[Category: Protein farnesyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Bon, R S.]]	+	[[Category: Bon, R S]]
-	[[Category: Goody, R S.]]	+	[[Category: Goody, R S]]
-	[[Category: Guo, Z.]]	+	[[Category: Guo, Z]]
-	[[Category: Stigter, E A.]]	+	[[Category: Stigter, E A]]
-	[[Category: Waldmann, H.]]	+	[[Category: Waldmann, H]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Protein prenylation]]		[[Category: Protein prenylation]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:34, 24 October 2012

OCA — Wed, 24 Oct 2012 07:34:57 GMT

←Older revision		Revision as of 07:34, 24 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gtm.jpg\|left\|200px]]

-	~~The entry~~ 4gtm ~~is ON HOLD~~	+	{{STRUCTURE_4gtm\| PDB=4gtm \| SCENE= }}

-	~~Authors: Guo, Z., Stigter, E.A., Bon, R.S., Waldmann, H., Blankenfeldt, W., Goody, R.S.~~	+	===FTase in complex with BMS analogue 11===

-	~~Description~~: ~~FTase in~~ complex ~~with BMS analogue 11~~	+	{{ABSTRACT_PUBMED_22963166}}
		+
		+	==About this Structure==
		+	[[4gtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTM OCA].
		+	[[Category: Protein farnesyltransferase]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Blankenfeldt, W.]]
		+	[[Category: Bon, R S.]]
		+	[[Category: Goody, R S.]]
		+	[[Category: Guo, Z.]]
		+	[[Category: Stigter, E A.]]
		+	[[Category: Waldmann, H.]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein prenylation]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:54, 19 September 2012

OCA — Wed, 19 Sep 2012 06:54:14 GMT

←Older revision		Revision as of 06:54, 19 September 2012
Line 3:		Line 3:
	The entry 4gtm is ON HOLD		The entry 4gtm is ON HOLD

-	Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S.	+	Authors: Guo, Z., Stigter, E.A., Bon, R.S., Waldmann, H., Blankenfeldt, W., Goody, R.S.

	Description: FTase in complex with BMS analogue 11		Description: FTase in complex with BMS analogue 11

OCA: Protected "4gtm" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:58:55 GMT

Protected "4gtm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gtm is ON HOLD Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S. Description: FTase in complex with BMS analogue...

OCA — Wed, 05 Sep 2012 04:58:54 GMT

New page: '''Unreleased structure''' The entry 4gtm is ON HOLD Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S. Description: FTase in complex with BMS analogue...

New page

'''Unreleased structure'''

The entry 4gtm is ON HOLD

Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S.

Description: FTase in complex with BMS analogue 11