4gtv - Revision history

OCA at 14:01, 8 November 2023

OCA — Wed, 08 Nov 2023 14:01:12 GMT

←Older revision		Revision as of 14:01, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [https://pdbe.org/4gtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [https://www.ebi.ac.uk/pdbsum/4gtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [https://pdbe.org/4gtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [https://www.ebi.ac.uk/pdbsum/4gtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:17, 26 October 2022

OCA — Wed, 26 Oct 2022 07:17:39 GMT

←Older revision		Revision as of 07:17, 26 October 2022
Line 1:		Line 1:

	==Engineered RabGGTase in complex with BMS analogue 13==		==Engineered RabGGTase in complex with BMS analogue 13==
-	<StructureSection load='4gtv' size='340' side='right' caption='[[4gtv]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4gtv' size='340' side='right'caption='[[4gtv]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gtm\|4gtm]], [[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [https://pdbe.org/4gtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [https://www.ebi.ac.uk/pdbsum/4gtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [~~http~~://pdbe.org/4gtv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gtv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.	+	[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Geranylgeranyl transferase\|Geranylgeranyl transferase]]	+	*[[Geranylgeranyl transferase 3D structures\|Geranylgeranyl transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Protein geranylgeranyltransferase type II~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Bon~~, R S~~]]	+	[[Category: Bon RS]]
-	[[Category: Goody~~, R S~~]]	+	[[Category: Goody RS]]
-	[[Category: Guo, Z]]	+	[[Category: Guo Z]]
-	[[Category: Stigter~~, E A~~]]	+	[[Category: Stigter EA]]
-	[[Category: Waldmann, H]]	+	[[Category: Waldmann H]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Protein prenylation]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 09:09, 5 August 2016

OCA — Fri, 05 Aug 2016 09:09:41 GMT

←Older revision		Revision as of 09:09, 5 August 2016
Line 1:		Line 1:
		+
	==Engineered RabGGTase in complex with BMS analogue 13==		==Engineered RabGGTase in complex with BMS analogue 13==
	<StructureSection load='4gtv' size='340' side='right' caption='[[4gtv]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4gtv' size='340' side='right' caption='[[4gtv]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gtm\|4gtm]], [[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gtm\|4gtm]], [[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [http://www.ebi.ac.uk/pdbsum/4gtv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [http://pdbe.org/4gtv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [http://www.ebi.ac.uk/pdbsum/4gtv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gtv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
-	[[Category: Rattus norvegicus]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]
	[[Category: Bon, R S]]		[[Category: Bon, R S]]

OCA at 17:33, 25 December 2014

OCA — Thu, 25 Dec 2014 17:33:05 GMT

←Older revision		Revision as of 17:33, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [http://www.ebi.ac.uk/pdbsum/4gtv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [http://www.ebi.ac.uk/pdbsum/4gtv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:54, 10 December 2014

OCA — Wed, 10 Dec 2014 09:54:40 GMT

←Older revision		Revision as of 09:54, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4gtv.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Engineered RabGGTase in complex with BMS analogue 13==
		+	<StructureSection load='4gtv' size='340' side='right' caption='[[4gtv]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gtv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GTV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TR:4-({(3R)-7-CYANO-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+DIETHYLCARBAMATE'>7TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gtm\|4gtm]], [[4gto\|4gto]], [[4gtp\|4gtp]], [[4gtq\|4gtq]], [[4gtr\|4gtr]], [[4gts\|4gts]], [[4gtt\|4gtt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rabggta, Ggta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Rabggtb, Ggtb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_geranylgeranyltransferase_type_II Protein geranylgeranyltransferase type II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.60 2.5.1.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gtv RCSB], [http://www.ebi.ac.uk/pdbsum/4gtv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the Ras superfamily of small GTPases are frequently mutated in cancer. Therefore, inhibitors have been developed to address the acitivity of these GTPases by inhibiting their prenylating enzymes FTase, GGTase I, and RabGGTase. In contrast to FTase and GGTase I, only a handful of RabGGTase inhibitors have been developed. The most active RabGGTase inhibitor known until recently was an FTase inhibitor which hit RabGGTase as an off-target. We recently reported our efforts to tune the selectivity of these inhibitors toward RabGGTase. Here we describe an extended set of selective inhibitors. The requirements for selective RabGGTase inhibitors are described in detail, guided by multiple crystal structures. In order to relate in vitro and cellular activity, a high-throughput assay system to detect the attachment of [(3)H]geranylgeranyl groups to Rab was used. Selective RabGGTase inhibition allows the establishment of novel drug discovery programs aimed at the development of anticancer therapeutics.

-	~~{{STRUCTURE_4gtv\| PDB=4gtv \| SCENE= }}~~	+	Development of Selective, Potent RabGGTase Inhibitors.,Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s. Epub 2012 Oct 3. PMID:22963166<ref>PMID:22963166</ref>

-	~~===Engineered RabGGTase in complex with BMS analogue 13===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22963166}}~~	+	==See Also==
-		+	*[[Geranylgeranyl transferase\|Geranylgeranyl transferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4gtv~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Protein geranylgeranyltransferase type II]]		[[Category: Protein geranylgeranyltransferase type II]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Blankenfeldt, W.]]	+	[[Category: Blankenfeldt, W]]
-	[[Category: Bon, R S.]]	+	[[Category: Bon, R S]]
-	[[Category: Goody, R S.]]	+	[[Category: Goody, R S]]
-	[[Category: Guo, Z.]]	+	[[Category: Guo, Z]]
-	[[Category: Stigter, E A.]]	+	[[Category: Stigter, E A]]
-	[[Category: Waldmann, H.]]	+	[[Category: Waldmann, H]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Protein prenylation]]		[[Category: Protein prenylation]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:39, 24 October 2012

OCA — Wed, 24 Oct 2012 07:39:09 GMT

←Older revision		Revision as of 07:39, 24 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4gtv.jpg\|left\|200px]]

-	~~The entry~~ 4gtv ~~is ON HOLD~~	+	{{STRUCTURE_4gtv\| PDB=4gtv \| SCENE= }}

-	~~Authors: Guo, Z., Stigter, E.A., Bon, R.S., Waldmann, H., Blankenfeldt, W., Goody, R.S.~~	+	===Engineered RabGGTase in complex with BMS analogue 13===

-	~~Description~~: ~~Engineered RabGGTase in~~ complex ~~with BMS analogue 13~~	+	{{ABSTRACT_PUBMED_22963166}}
		+
		+	==About this Structure==
		+	[[4gtv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTV OCA].
		+	[[Category: Protein geranylgeranyltransferase type II]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Blankenfeldt, W.]]
		+	[[Category: Bon, R S.]]
		+	[[Category: Goody, R S.]]
		+	[[Category: Guo, Z.]]
		+	[[Category: Stigter, E A.]]
		+	[[Category: Waldmann, H.]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein prenylation]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 20:08, 26 September 2012

OCA — Wed, 26 Sep 2012 20:08:38 GMT

←Older revision		Revision as of 20:08, 26 September 2012
Line 3:		Line 3:
	The entry 4gtv is ON HOLD		The entry 4gtv is ON HOLD

-	Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S.	+	Authors: Guo, Z., Stigter, E.A., Bon, R.S., Waldmann, H., Blankenfeldt, W., Goody, R.S.

	Description: Engineered RabGGTase in complex with BMS analogue 13		Description: Engineered RabGGTase in complex with BMS analogue 13

OCA: Protected "4gtv" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 04:59:09 GMT

Protected "4gtv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gtv is ON HOLD Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S. Description: Engineered RabGGTase in complex wi...

OCA — Wed, 05 Sep 2012 04:59:08 GMT

New page: '''Unreleased structure''' The entry 4gtv is ON HOLD Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S. Description: Engineered RabGGTase in complex wi...

New page

'''Unreleased structure'''

The entry 4gtv is ON HOLD

Authors: Guo, Z, Stigter E. A., Bon, R.S., Waldmann H., Blankenfeldt W., Goody R.S.

Description: Engineered RabGGTase in complex with BMS analogue 13