4gv7 - Revision history

OCA at 14:02, 8 November 2023

OCA — Wed, 08 Nov 2023 14:02:17 GMT

←Older revision		Revision as of 14:02, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [https://pdbe.org/4gv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [https://pdbe.org/4gv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:19, 26 October 2022

OCA — Wed, 26 Oct 2022 07:19:50 GMT

←Older revision		Revision as of 07:19, 26 October 2022
Line 1:		Line 1:

	==Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328==		==Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328==
-	<StructureSection load='4gv7' size='340' side='right' caption='[[4gv7]], [[Resolution\|resolution]] 2.89Å' scene=''>	+	<StructureSection load='4gv7' size='340' side='right'caption='[[4gv7]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [https://pdbe.org/4gv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [https://www.ebi.ac.uk/pdbsum/4gv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv7 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [~~http~~://pdbe.org/4gv7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gv7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>	+	[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Andersson~~, C D~~]]	+	[[Category: Large Structures]]
-	[[Category: Ekblad, T]]	+	[[Category: Andersson CD]]
-	[[Category: Elofsson, M]]	+	[[Category: Ekblad T]]
-	[[Category: Karlberg, T]]	+	[[Category: Elofsson M]]
-	[[Category: Lindgren~~, A E.G~~]]	+	[[Category: Karlberg T]]
-	[[Category: Linusson, A]]	+	[[Category: Lindgren AEG]]
-	[[Category: Schuler, H]]	+	[[Category: Linusson A]]
-	[[Category: Spjut, S]]	+	[[Category: Schuler H]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Spjut S]]
-	[[Category: Weigelt, J]]	+	[[Category: Thorsell AG]]
-	~~[[Category: Adp-ribose]]~~	+	[[Category: Weigelt J]]
-	~~[[Category: Adp-ribose transferase]]~~	+
-	~~[[Category: Adp-ribosylation]]~~	+
-	~~[[Category: Artd transferase domain]]~~	+
-	~~[[Category: Artd1]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Parp1]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 21:05, 4 August 2016

OCA — Thu, 04 Aug 2016 21:05:23 GMT

←Older revision		Revision as of 21:05, 4 August 2016
Line 1:		Line 1:
		+
	==Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328==		==Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328==
	<StructureSection load='4gv7' size='340' side='right' caption='[[4gv7]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='4gv7' size='340' side='right' caption='[[4gv7]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [http://pdbe.org/4gv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gv7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Andersson, C D]]		[[Category: Andersson, C D]]
	[[Category: Ekblad, T]]		[[Category: Ekblad, T]]

OCA at 19:38, 24 December 2014

OCA — Wed, 24 Dec 2014 19:38:57 GMT

←Older revision		Revision as of 19:38, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gv7\| PDB=4gv7 \| SCENE= }}~~	+	==Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328==
-	===Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328===	+	<StructureSection load='4gv7' size='340' side='right' caption='[[4gv7]], [[Resolution\|resolution]] 2.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23742272}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GV7 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEW:2-METHYLQUINAZOLIN-4(3H)-ONE'>MEW</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gv7 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv7 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>		[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the cellular targets are poorly characterized. Here we describe an inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3), a regulator of DNA repair and mitotic progression. In vitro profiling against 12 members of the enzyme family suggests selectivity for ARTD3, and crystal structures illustrate the molecular basis for inhibitor selectivity. The compound is active in cells, where it elicits ARTD3-specific effects at sub-micromolar concentration. Our results show that by targeting the nicotinamide binding site, selective inhibition can be achieved among the closest relatives of the validated clinical target, ADP-ribosyltransferase-1/poly(ADP-ribose) polymerase-1.

-	~~==About this Structure==~~	+	A PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.,Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schuler H ACS Chem Biol. 2013 Jun 6. PMID:23742272<ref>PMID:23742272</ref>
-	~~[[4gv7]] is a 4 chain structure~~ with ~~sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4GV7 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]		*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023742272</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Andersson, C D.]]	+	[[Category: Andersson, C D]]
-	[[Category: Ekblad, T.]]	+	[[Category: Ekblad, T]]
-	[[Category: Elofsson, M.]]	+	[[Category: Elofsson, M]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Lindgren, A E.G.]]	+	[[Category: Lindgren, A E.G]]
-	[[Category: Linusson, A.]]	+	[[Category: Linusson, A]]
-	[[Category: Schuler, H.]]	+	[[Category: Schuler, H]]
-	[[Category: Spjut, S.]]	+	[[Category: Spjut, S]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Adp-ribose]]		[[Category: Adp-ribose]]
	[[Category: Adp-ribose transferase]]		[[Category: Adp-ribose transferase]]

OCA at 06:57, 16 October 2013

OCA — Wed, 16 Oct 2013 06:57:18 GMT

←Older revision		Revision as of 06:57, 16 October 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA].		[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA].
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]

	==Reference==		==Reference==

OCA at 16:10, 19 June 2013

OCA — Wed, 19 Jun 2013 16:10:49 GMT

←Older revision		Revision as of 16:10, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gv7\| PDB=4gv7 \| SCENE= }}
		+	===Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328===
		+	{{ABSTRACT_PUBMED_23742272}}

-	~~The entry 4gv7~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

-	~~Authors~~: ~~Karlberg, T~~.~~, Thorsell, A~~.G.~~, Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J~~.~~, Linusson, A~~.~~, Elofsson, M~~.~~, Schuler, H~~.	+	==About this Structure==
		+	[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA].

-	~~Description~~: ~~Human ARTD1 (PARP1)~~ -~~Catalytic~~ domain ~~in complex with~~ inhibitor ~~ME0328~~	+	==Reference==
		+	<ref group="xtra">PMID:023742272</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Andersson, C D.]]
		+	[[Category: Ekblad, T.]]
		+	[[Category: Elofsson, M.]]
		+	[[Category: Karlberg, T.]]
		+	[[Category: Lindgren, A E.G.]]
		+	[[Category: Linusson, A.]]
		+	[[Category: Schuler, H.]]
		+	[[Category: Spjut, S.]]
		+	[[Category: Thorsell, A G.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Adp-ribose]]
		+	[[Category: Adp-ribose transferase]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Artd transferase domain]]
		+	[[Category: Artd1]]
		+	[[Category: Nad]]
		+	[[Category: Parp1]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:32, 17 October 2012

OCA — Wed, 17 Oct 2012 06:32:12 GMT

←Older revision		Revision as of 06:32, 17 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gv7 is ON HOLD	+	The entry 4gv7 is ON HOLD until Paper Publication

	Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.		Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.

	Description: Human ARTD1 (PARP1) -Catalytic domain in complex with inhibitor ME0328		Description: Human ARTD1 (PARP1) -Catalytic domain in complex with inhibitor ME0328

OCA at 20:08, 26 September 2012

OCA — Wed, 26 Sep 2012 20:08:53 GMT

←Older revision		Revision as of 20:08, 26 September 2012
Line 5:		Line 5:
	Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.		Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.

-	Description: ~~HUMAN~~ ARTD1 (PARP1) -~~CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR~~ ME0328	+	Description: Human ARTD1 (PARP1) -Catalytic domain in complex with inhibitor ME0328

OCA: Protected "4gv7" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2012 05:00:34 GMT

Protected "4gv7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 5 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gv7 is ON HOLD Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson...

OCA — Wed, 05 Sep 2012 05:00:33 GMT

New page: '''Unreleased structure''' The entry 4gv7 is ON HOLD Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson...

New page

'''Unreleased structure'''

The entry 4gv7 is ON HOLD

Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.

Description: HUMAN ARTD1 (PARP1) -CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR ME0328