4gzf - Revision history

OCA at 14:58, 20 September 2023

OCA — Wed, 20 Sep 2023 14:58:30 GMT

←Older revision		Revision as of 14:58, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gzf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gzf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DC0:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-PHENYLALANINE'>DC0</scene>, <scene name='pdbligand=ILO:N5-IMINOETHYL-L-ORNITHINE'>ILO</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DC0:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-PHENYLALANINE'>DC0</scene>, <scene name='pdbligand=ILO:N5-IMINOETHYL-L-ORNITHINE'>ILO</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [https://pdbe.org/4gzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [https://www.ebi.ac.uk/pdbsum/4gzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [https://pdbe.org/4gzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [https://www.ebi.ac.uk/pdbsum/4gzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:49, 3 November 2022

OCA — Thu, 03 Nov 2022 07:49:31 GMT

←Older revision		Revision as of 07:49, 3 November 2022
Line 1:		Line 1:

	==Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide==		==Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide==
-	<StructureSection load='4gzf' size='340' side='right' caption='[[4gzf]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4gzf' size='340' side='right'caption='[[4gzf]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gzf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GZF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gzf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZF FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=DC0:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-PHENYLALANINE'>DC0</scene>, <scene name='pdbligand=ILO:N5-IMINOETHYL-L-ORNITHINE'>ILO</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DC0:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-PHENYLALANINE'>DC0</scene>, <scene name='pdbligand=ILO:N5-IMINOETHYL-L-ORNITHINE'>ILO</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gye\|4gye]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [https://pdbe.org/4gzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [https://www.ebi.ac.uk/pdbsum/4gzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzf ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [~~http~~://pdbe.org/4gzf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gzf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9QM22_9HIV1 Q9QM22_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4gzf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4gzf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~HIV-~~1 ~~retropepsin~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Brunzelle, J S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dewdney, T G~~]]	+	[[Category: Brunzelle JS]]
-	[[Category: ~~Kovari, I A~~]]	+	[[Category: Dewdney TG]]
-	[[Category: Kovari~~, L C~~]]	+	[[Category: Kovari IA]]
-	[[Category: ~~Reiter, S J~~]]	+	[[Category: Kovari LC]]
-	[[Category: ~~Wang, Y~~]]	+	[[Category: Reiter SJ]]
-	[[Category: ~~Drug resistance]]~~	+	[[Category: Wang Y]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Multi-drug resistance]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Substrate peptide~~]]	+

OCA at 19:57, 15 December 2016

OCA — Thu, 15 Dec 2016 19:57:51 GMT

←Older revision		Revision as of 19:57, 15 December 2016
Line 1:		Line 1:
		+
	==Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide==		==Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide==
	<StructureSection load='4gzf' size='340' side='right' caption='[[4gzf]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4gzf' size='340' side='right' caption='[[4gzf]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [http://www.ebi.ac.uk/pdbsum/4gzf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [http://pdbe.org/4gzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [http://www.ebi.ac.uk/pdbsum/4gzf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gzf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:07, 15 February 2015

OCA — Sun, 15 Feb 2015 09:07:03 GMT

←Older revision		Revision as of 09:07, 15 February 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4gzf\| PDB=4gzf \| SCENE= }}~~	+	==Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide==
-	===Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide===	+	<StructureSection load='4gzf' size='340' side='right' caption='[[4gzf]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24128815}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gzf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZF FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DC0:N-[(2S)-2-AMINO-4-METHYLPENTYL]-L-PHENYLALANINE'>DC0</scene>, <scene name='pdbligand=ILO:N5-IMINOETHYL-L-ORNITHINE'>ILO</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gye\|4gye]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzf RCSB], [http://www.ebi.ac.uk/pdbsum/4gzf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for antiretroviral drug design for the treatment of HIV-1 infected patients. To examine the role of the P1 and P1'positions of the substrate in inhibitory efficacy of multi-drug resistant HIV-1 protease 769 (MDR 769), we performed a series of structure-function studies. Using the original CA/p2 cleavage site sequence, we generated heptapeptides containing one reduced peptide bond with an L to F and A to F double mutation at P1 and P1' (F-r-F), and an A to F at P1' (L-r-F) resulting in P1/P1' modified ligands. Here, we present an analysis of co-crystal structures of CA/p2 F-r-F, and CA/p2 L-r-F in complex with MDR 769. To examine conformational changes in the complex structure, molecular dynamic (MD) simulations were performed with MDR769-ligand complexes. MD trajectories show the isobutyl group of both the lopinavir analog and the CA/p2 L-r-F substrate cause a conformational change of in the active site of MDR 769. IC50 measurements suggest the non identical P1/P1' ligands (CA/p2 L-r-F and lopinavir analog) are more effective against MDR proteases as opposed to identical P1/P1'ligands. Our results suggest that a non identical P1/P1'composition may be more favorable for the inhibition of MDR 769 as they induce conformational changes in the active site of the enzyme resulting in disruption of the two-fold symmetry of the protease, thus, stabilizing the inhibitor in the active site.

-	~~==About this Structure==~~	+	Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.,Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC Bioorg Med Chem. 2013 Sep 27. pii: S0968-0896(13)00825-0. doi:, 10.1016/j.bmc.2013.09.045. PMID:24128815<ref>PMID:24128815</ref>
-	~~[[4gzf]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/9hiv1 9hiv1]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4GZF OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024128815</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	~~[[Category: 9hiv1]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
-	[[Category: Brunzelle, J S.]]	+	[[Category: Brunzelle, J S]]
-	[[Category: Dewdney, T G.]]	+	[[Category: Dewdney, T G]]
-	[[Category: Kovari, I A.]]	+	[[Category: Kovari, I A]]
-	[[Category: Kovari, L C.]]	+	[[Category: Kovari, L C]]
-	[[Category: Reiter, S J.]]	+	[[Category: Reiter, S J]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, Y]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:53, 13 November 2013

OCA — Wed, 13 Nov 2013 06:53:20 GMT

←Older revision		Revision as of 06:53, 13 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4gzf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA].	+	[[4gzf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024128815</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024128815</ref><references group="xtra"/><references/>
		+	[[Category: 9hiv1]]
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
-	[[Category: Human immunodeficiency virus 1]]
	[[Category: Brunzelle, J S.]]		[[Category: Brunzelle, J S.]]
	[[Category: Dewdney, T G.]]		[[Category: Dewdney, T G.]]

OCA at 09:37, 30 October 2013

OCA — Wed, 30 Oct 2013 09:37:26 GMT

←Older revision		Revision as of 09:37, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gzf\| PDB=4gzf \| SCENE= }}
		+	===Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide===
		+	{{ABSTRACT_PUBMED_24128815}}

-	~~The entry~~ 4gzf is ~~ON HOLD until Mar 06 2015~~	+	==About this Structure==
		+	[[4gzf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZF OCA].

-	~~Authors~~: Dewdney, T.G.~~, Wang, Y.,~~ Kovari, I.A., ~~Brunzelle, J~~.~~S.,~~ Reiter, S.J., ~~Kovari, L.C~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024128815</ref><references group="xtra"/><references/>
-	~~Description~~: Multi-drug ~~resistant HIV-1 protease 769 variant with reduced LrF~~ peptide	+	[[Category: HIV-1 retropepsin]]
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Brunzelle, J S.]]
		+	[[Category: Dewdney, T G.]]
		+	[[Category: Kovari, I A.]]
		+	[[Category: Kovari, L C.]]
		+	[[Category: Reiter, S J.]]
		+	[[Category: Wang, Y.]]
		+	[[Category: Drug resistance]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Multi-drug resistance]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Substrate peptide]]

OCA at 07:02, 14 August 2013

OCA — Wed, 14 Aug 2013 07:02:56 GMT

←Older revision		Revision as of 07:02, 14 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gzf is ON HOLD until ~~Paper Publication~~	+	The entry 4gzf is ON HOLD until Mar 06 2015

	Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C.		Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C.

	Description: Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide		Description: Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide

OCA at 20:42, 12 December 2012

OCA — Wed, 12 Dec 2012 20:42:26 GMT

←Older revision		Revision as of 20:42, 12 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gzf is ON HOLD	+	The entry 4gzf is ON HOLD until Paper Publication

	Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C.		Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C.

	Description: Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide		Description: Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide

OCA: Protected "4gzf" [edit=sysop:move=sysop]

OCA — Wed, 12 Sep 2012 04:57:36 GMT

Protected "4gzf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 12 September 2012

OCA: New page: '''Unreleased structure''' The entry 4gzf is ON HOLD Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C. Description: Multi-drug resistant HIV-1...

OCA — Wed, 12 Sep 2012 04:57:35 GMT

New page: '''Unreleased structure''' The entry 4gzf is ON HOLD Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C. Description: Multi-drug resistant HIV-1...

New page

'''Unreleased structure'''

The entry 4gzf is ON HOLD

Authors: Dewdney, T.G., Wang, Y., Kovari, I.A., Brunzelle, J.S., Reiter, S.J., Kovari, L.C.

Description: Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide