4gzu - Revision history

OCA at 16:00, 14 March 2024

OCA — Thu, 14 Mar 2024 16:00:50 GMT

←Older revision		Revision as of 16:00, 14 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [https://pdbe.org/4gzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [https://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [https://pdbe.org/4gzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [https://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref> <ref>PMID:16286926</ref>		[https://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref> <ref>PMID:16286926</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	FARP2 is a Dbl-family guanine nucleotide exchange factor (GEF) that contains a 4.1, ezrin, radixin and moesin (FERM) domain, a Dbl-homology (DH) domain and two pleckstrin homology (PH) domains. FARP2 activates Rac1 or Cdc42 in response to upstream signals, thereby regulating processes such as neuronal axon guidance and bone homeostasis. How the GEF activity of FARP2 is regulated remained poorly understood. We have determined the crystal structures of the catalytic DH domain and the DH-PH-PH domains of FARP2. The structures reveal an auto-inhibited conformation in which the GEF substrate-binding site is blocked collectively by the last helix in the DH domain and the two PH domains. This conformation is stabilized by multiple interactions among the domains and two well-structured inter-domain linkers. Our cell-based activity assays confirm the suppression of the FARP2 GEF activity by these auto-inhibitory elements.
-
-	Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.,He X, Kuo YC, Rosche TJ, Zhang X Structure. 2013 Mar 5;21(3):355-64. doi: 10.1016/j.str.2013.01.001. Epub 2013 Jan, 31. PMID:23375260<ref>PMID:23375260</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4gzu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:50, 3 November 2022

OCA — Thu, 03 Nov 2022 07:50:15 GMT

←Older revision		Revision as of 07:50, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of the DH-PH-PH domain of FARP2==		==Crystal structure of the DH-PH-PH domain of FARP2==
-	<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4gzu' size='340' side='right'caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4GZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [https://pdbe.org/4gzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [https://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [~~http~~://pdbe.org/4gzu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE]] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref> <ref>PMID:16286926</ref>	+	[https://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref> <ref>PMID:16286926</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~He, X~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Zhang,~~ X]]	+	[[Category: He X]]
-	[[Category: ~~Dhph]]~~	+	[[Category: Zhang X]]
-	~~[[Category: Farp2]]~~	+
-	~~[[Category: Gef]]~~	+
-	~~[[Category: Guanine nucleotide exchange factor]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:34, 15 November 2017

OCA — Wed, 15 Nov 2017 08:34:14 GMT

←Older revision		Revision as of 08:34, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://pdbe.org/4gzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://pdbe.org/4gzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Zhang, X]]		[[Category: Zhang, X]]

OCA at 14:26, 22 December 2016

OCA — Thu, 22 Dec 2016 14:26:50 GMT

←Older revision		Revision as of 14:26, 22 December 2016
Line 1:		Line 1:

-	==Crystal ~~strucure~~ of the DH-PH-PH domain of FARP2==	+	==Crystal structure of the DH-PH-PH domain of FARP2==
	<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://pdbe.org/4gzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://pdbe.org/4gzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Zhang, X]]		[[Category: Zhang, X]]

OCA at 21:47, 5 August 2016

OCA — Fri, 05 Aug 2016 21:47:21 GMT

←Older revision		Revision as of 21:47, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal strucure of the DH-PH-PH domain of FARP2==		==Crystal strucure of the DH-PH-PH domain of FARP2==
	<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://pdbe.org/4gzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4gzu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Zhang, X]]		[[Category: Zhang, X]]

OCA at 22:11, 25 December 2014

OCA — Thu, 25 Dec 2014 22:11:10 GMT

←Older revision		Revision as of 22:11, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE]] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref> <ref>PMID:16286926</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:29, 21 December 2014

OCA — Sun, 21 Dec 2014 11:29:07 GMT

←Older revision		Revision as of 11:29, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4gzu~~\| ~~PDB~~=4gzu \| ~~SCENE~~= }}	+	==Crystal strucure of the DH-PH-PH domain of FARP2==
-	===~~Crystal strucure~~ of the DH-PH-PH domain of FARP2~~===~~	+	<StructureSection load='4gzu' size='340' side='right' caption='[[4gzu]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23375260}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZU FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gyv\|4gyv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Farp2, Kiaa0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzu RCSB], [http://www.ebi.ac.uk/pdbsum/4gzu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	FARP2 is a Dbl-family guanine nucleotide exchange factor (GEF) that contains a 4.1, ezrin, radixin and moesin (FERM) domain, a Dbl-homology (DH) domain and two pleckstrin homology (PH) domains. FARP2 activates Rac1 or Cdc42 in response to upstream signals, thereby regulating processes such as neuronal axon guidance and bone homeostasis. How the GEF activity of FARP2 is regulated remained poorly understood. We have determined the crystal structures of the catalytic DH domain and the DH-PH-PH domains of FARP2. The structures reveal an auto-inhibited conformation in which the GEF substrate-binding site is blocked collectively by the last helix in the DH domain and the two PH domains. This conformation is stabilized by multiple interactions among the domains and two well-structured inter-domain linkers. Our cell-based activity assays confirm the suppression of the FARP2 GEF activity by these auto-inhibitory elements.

-	~~==Function==~~	+	Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.,He X, Kuo YC, Rosche TJ, Zhang X Structure. 2013 Mar 5;21(3):355-64. doi: 10.1016/j.str.2013.01.001. Epub 2013 Jan, 31. PMID:23375260<ref>PMID:23375260</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/FARP2_MOUSE FARP2_MOUSE]] Rho-guanine nucleotide exchange factor that activates RAC1~~. ~~Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton~~.~~<ref>~~PMID:~~12351724</ref>~~<ref>PMID:~~16286926~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4gzu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: He, X.]]	+	[[Category: He, X]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: Dhph]]		[[Category: Dhph]]
	[[Category: Farp2]]		[[Category: Farp2]]

OCA at 07:45, 27 March 2013

OCA — Wed, 27 Mar 2013 07:45:15 GMT

←Older revision		Revision as of 07:45, 27 March 2013
Line 2:		Line 2:
	===Crystal strucure of the DH-PH-PH domain of FARP2===		===Crystal strucure of the DH-PH-PH domain of FARP2===
	{{ABSTRACT_PUBMED_23375260}}		{{ABSTRACT_PUBMED_23375260}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FARP2_MOUSE FARP2_MOUSE]] Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.<ref>PMID:12351724</ref><ref>PMID:16286926</ref>

	==About this Structure==		==About this Structure==
	[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA].		[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: He, X.]]		[[Category: He, X.]]

OCA at 10:22, 13 March 2013

OCA — Wed, 13 Mar 2013 10:22:52 GMT

←Older revision		Revision as of 10:22, 13 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4gzu\| PDB=4gzu \| SCENE= }}
		+	===Crystal strucure of the DH-PH-PH domain of FARP2===
		+	{{ABSTRACT_PUBMED_23375260}}

-	~~The entry~~ 4gzu is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4gzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZU OCA].
-	~~Authors~~: He, X., Zhang, X.	+	[[Category: Mus musculus]]
-		+	[[Category: He, X.]]
-	~~Description~~: ~~Crystal strucure of the DH-PH-PH domain of FARP2~~	+	[[Category: Zhang, X.]]
		+	[[Category: Dhph]]
		+	[[Category: Farp2]]
		+	[[Category: Gef]]
		+	[[Category: Guanine nucleotide exchange factor]]
		+	[[Category: Signaling protein]]

OCA at 13:19, 20 February 2013

OCA — Wed, 20 Feb 2013 13:19:04 GMT

←Older revision		Revision as of 13:19, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4gzu is ON HOLD	+	The entry 4gzu is ON HOLD until Paper Publication

	Authors: He, X., Zhang, X.		Authors: He, X., Zhang, X.

	Description: Crystal strucure of the DH-PH-PH domain of FARP2		Description: Crystal strucure of the DH-PH-PH domain of FARP2