4h14 - Revision history

OCA at 07:52, 3 November 2022

OCA — Thu, 03 Nov 2022 07:52:23 GMT

←Older revision		Revision as of 07:52, 3 November 2022
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	<StructureSection load='4h14' size='340' side='right'caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4h14' size='340' side='right'caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bcv Bcv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H14 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r4d\|3r4d]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h14 OCA], [https://pdbe.org/4h14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h14 RCSB], [https://www.ebi.ac.uk/pdbsum/4h14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h14 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h14 OCA], [~~http~~://pdbe.org/4h14 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h14 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h14 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h14 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q1HLC5_9BETC Q1HLC5_9BETC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4h14" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4h14" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sandbox 3001\|Sandbox 3001]]
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bcv~~]]	+	[[Category: Bovine coronavirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Sugar binding]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:15, 27 March 2019

OCA — Wed, 27 Mar 2019 08:15:52 GMT

←Older revision		Revision as of 08:15, 27 March 2019
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	==Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain==		==Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain==
-	<StructureSection load='4h14' size='340' side='right' caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4h14' size='340' side='right'caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bcv Bcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H14 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bcv Bcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H14 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bcv]]		[[Category: Bcv]]
		+	[[Category: Large Structures]]
	[[Category: Li, F]]		[[Category: Li, F]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 14:20, 4 August 2016

OCA — Thu, 04 Aug 2016 14:20:46 GMT

←Older revision		Revision as of 14:20, 4 August 2016
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		+
	==Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain==		==Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain==
	<StructureSection load='4h14' size='340' side='right' caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4h14' size='340' side='right' caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bovine_coronavirus Bovine coronavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bcv Bcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H14 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r4d\|3r4d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r4d\|3r4d]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h14 RCSB], [http://www.ebi.ac.uk/pdbsum/4h14 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h14 OCA], [http://pdbe.org/4h14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h14 RCSB], [http://www.ebi.ac.uk/pdbsum/4h14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h14 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h14" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovine coronavirus~~]]	+	[[Category: Bcv]]
	[[Category: Li, F]]		[[Category: Li, F]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 11:42, 21 December 2014

OCA — Sun, 21 Dec 2014 11:42:51 GMT

←Older revision		Revision as of 11:42, 21 December 2014
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-	~~{{STRUCTURE_4h14\| PDB=4h14 \| SCENE= }}~~	+	==Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain==
-	===Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain===	+	<StructureSection load='4h14' size='340' side='right' caption='[[4h14]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23091051}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H14 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r4d\|3r4d]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h14 RCSB], [http://www.ebi.ac.uk/pdbsum/4h14 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The spike protein N-terminal domains (NTDs) of bovine coronavirus (BCoV) and mouse hepatitis coronavirus (MHV) recognize sugar and protein receptors, respectively, despite their significant sequence homology. We recently determined the crystal structure of MHV NTD complexed with its protein receptor murine carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), which surprisingly revealed a human galectin (galactose-binding lectin) fold in MHV NTD. Here, we have determined at 1.55 A resolution the crystal structure of BCoV NTD, which also has the human galectin fold. Using mutagenesis, we have located the sugar-binding site in BCoV NTD, which overlaps with the galactose-binding site in human galectins. Using a glycan array screen, we have identified 5-N-acetyl-9-O-acetylneuraminic acid as the preferred sugar substrate for BCoV NTD. Subtle structural differences between BCoV and MHV NTDs, primarily involving different conformations of receptor-binding loops, explain why BCoV NTD does not bind CEACAM1 and why MHV NTD does not bind sugar. These results suggest a successful viral evolution strategy in which coronaviruses stole a galectin from hosts, incorporated it into their spike protein, and evolved it into viral receptor-binding domains with altered sugar specificity in contemporary BCoV or novel protein specificity in contemporary MHV.

-	~~==About this Structure==~~	+	Crystal structure of bovine coronavirus spike protein lectin domain.,Peng G, Xu L, Lin YL, Chen L, Pasquarella JR, Holmes KV, Li F J Biol Chem. 2012 Dec 7;287(50):41931-8. doi: 10.1074/jbc.M112.418210. Epub 2012 , Oct 22. PMID:23091051<ref>PMID:23091051</ref>
-	~~[[4h14]] is a 1 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bovine_coronavirus Bovine coronavirus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4H14 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023091051</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bovine coronavirus]]		[[Category: Bovine coronavirus]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 16:06, 19 June 2013

OCA — Wed, 19 Jun 2013 16:06:04 GMT

←Older revision		Revision as of 16:06, 19 June 2013
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-	[[Image:4h14.jpg\|left\|200px]]
-
	{{STRUCTURE_4h14\| PDB=4h14 \| SCENE= }}		{{STRUCTURE_4h14\| PDB=4h14 \| SCENE= }}
-
	===Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain===		===Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain===
-		+	{{ABSTRACT_PUBMED_23091051}}

	==About this Structure==		==About this Structure==
	[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA].		[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023091051</ref><references group="xtra"/><references/>
	[[Category: Bovine coronavirus]]		[[Category: Bovine coronavirus]]
	[[Category: Li, F.]]		[[Category: Li, F.]]

OCA at 09:26, 31 October 2012

OCA — Wed, 31 Oct 2012 09:26:38 GMT

←Older revision		Revision as of 09:26, 31 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4h14.jpg\|left\|200px]]

-	~~The entry~~ 4h14 ~~is ON HOLD~~	+	{{STRUCTURE_4h14\| PDB=4h14 \| SCENE= }}

-	~~Authors: Li, F.~~	+	===Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain===

-	~~Description: Crystal~~ Structure of Bovine ~~Coronavirus Spike Protein Lectin Domain~~	+
		+	==About this Structure==
		+	[[4h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_coronavirus Bovine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H14 OCA].
		+	[[Category: Bovine coronavirus]]
		+	[[Category: Li, F.]]
		+	[[Category: Beta-sandwich]]
		+	[[Category: Sugar binding]]
		+	[[Category: Viral protein]]

OCA: Protected "4h14" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2012 06:57:10 GMT

Protected "4h14" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:57, 19 September 2012

OCA: New page: '''Unreleased structure''' The entry 4h14 is ON HOLD Authors: Li, F. Description: Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain

OCA — Wed, 19 Sep 2012 06:57:09 GMT

New page: '''Unreleased structure''' The entry 4h14 is ON HOLD Authors: Li, F. Description: Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain

New page

'''Unreleased structure'''

The entry 4h14 is ON HOLD

Authors: Li, F.

Description: Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain