4h1w - Revision history

OCA at 11:35, 1 March 2024

OCA — Fri, 01 Mar 2024 11:35:27 GMT

←Older revision		Revision as of 11:35, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H1W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [https://pdbe.org/4h1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [https://www.ebi.ac.uk/pdbsum/4h1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h1w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [https://pdbe.org/4h1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [https://www.ebi.ac.uk/pdbsum/4h1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h1w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).		[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The contraction and relaxation of muscle cells is controlled by the successive rise and fall of cytosolic Ca(2+), initiated by the release of Ca(2+) from the sarcoplasmic reticulum and terminated by re-sequestration of Ca(2+) into the sarcoplasmic reticulum as the main mechanism of Ca(2+) removal. Re-sequestration requires active transport and is catalysed by the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), which has a key role in defining the contractile properties of skeletal and heart muscle tissue. The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enters the intramembranous binding sites of SERCA have remained unknown. Here we report the crystal structure of rabbit SERCA1a (also known as ATP2A1) in complex with SLN at 3.1 A resolution. The regulatory SLN traps the Ca(2+)-ATPase in a previously undescribed E1 state, with exposure of the Ca(2+) sites through an open cytoplasmic pathway stabilized by Mg(2+). The structure suggests a mechanism for selective Ca(2+) loading and activation of SERCA, and provides new insight into how SLN and PLB inhibition arises from stabilization of this E1 intermediate state without bound Ca(2+). These findings may prove useful in studying how autoinhibitory domains of other ion pumps modulate transport across biological membranes.
-
-	The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm.,Winther AM, Bublitz M, Karlsen JL, Moller JV, Hansen JB, Nissen P, Buch-Pedersen MJ Nature. 2013 Mar 14;495(7440):265-9. doi: 10.1038/nature11900. Epub 2013 Mar 3. PMID:23455424<ref>PMID:23455424</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[ATPase 3D structures\|ATPase 3D structures]]		*[[ATPase 3D structures\|ATPase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:54, 3 November 2022

OCA — Thu, 03 Nov 2022 07:54:03 GMT

←Older revision		Revision as of 07:54, 3 November 2022
Line 3:		Line 3:
	<StructureSection load='4h1w' size='340' side='right'caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4h1w' size='340' side='right'caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c8k\|2c8k]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[3b9b\|3b9b]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [https://pdbe.org/4h1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [https://www.ebi.ac.uk/pdbsum/4h1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h1w ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [~~http~~://pdbe.org/4h1w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h1w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h1w ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Calcium-transporting ATPase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Bublitz, M]]	+	[[Category: Bublitz M]]
-	[[Category: Buch-Pedersen~~, M J~~]]	+	[[Category: Buch-Pedersen MJ]]
-	[[Category: Hansen~~, J B~~]]	+	[[Category: Hansen JB]]
-	[[Category: Karlsen, J]]	+	[[Category: Karlsen J]]
-	[[Category: Moller~~, J V~~]]	+	[[Category: Moller JV]]
-	[[Category: Nissen, P]]	+	[[Category: Nissen P]]
-	[[Category: Winther, A ~~M.L]]~~	+	[[Category: Winther A-ML]]
-	~~[[Category: Ca2+ transport]]~~	+
-	~~[[Category: Hydrolase~~-~~hydrolase regulator complex]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: P-type atpase]]~~	+
-	~~[[Category: Phospholamban]]~~	+
-	~~[[Category: Sarcolipin~~]]	+

OCA at 09:20, 5 February 2020

OCA — Wed, 05 Feb 2020 09:20:24 GMT

←Older revision		Revision as of 09:20, 5 February 2020
Line 1:		Line 1:

	==E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin==		==E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin==
-	<StructureSection load='4h1w' size='340' side='right' caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='4h1w' size='340' side='right'caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H1W FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H1W FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Bublitz, M]]		[[Category: Bublitz, M]]

OCA at 08:34, 15 November 2017

OCA — Wed, 15 Nov 2017 08:34:53 GMT

←Older revision		Revision as of 08:34, 15 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[ATPase\|ATPase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:59, 4 August 2016

OCA — Thu, 04 Aug 2016 17:59:38 GMT

←Older revision		Revision as of 17:59, 4 August 2016
Line 1:		Line 1:
		+
	==E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin==		==E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin==
	<StructureSection load='4h1w' size='340' side='right' caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4h1w' size='340' side='right' caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c8k\|2c8k]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[3b9b\|3b9b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c8k\|2c8k]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[3b9b\|3b9b]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [http://www.ebi.ac.uk/pdbsum/4h1w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [http://pdbe.org/4h1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [http://www.ebi.ac.uk/pdbsum/4h1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h1w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h1w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase\|ATPase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:44, 21 December 2014

OCA — Sun, 21 Dec 2014 10:44:45 GMT

←Older revision		Revision as of 10:44, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4h1w\| PDB=4h1w \| SCENE= }}~~	+	==E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin==
-	===E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin===	+	<StructureSection load='4h1w' size='340' side='right' caption='[[4h1w]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23455424}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4h1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H1W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c8k\|2c8k]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[3b9b\|3b9b]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h1w RCSB], [http://www.ebi.ac.uk/pdbsum/4h1w PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The contraction and relaxation of muscle cells is controlled by the successive rise and fall of cytosolic Ca(2+), initiated by the release of Ca(2+) from the sarcoplasmic reticulum and terminated by re-sequestration of Ca(2+) into the sarcoplasmic reticulum as the main mechanism of Ca(2+) removal. Re-sequestration requires active transport and is catalysed by the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), which has a key role in defining the contractile properties of skeletal and heart muscle tissue. The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enters the intramembranous binding sites of SERCA have remained unknown. Here we report the crystal structure of rabbit SERCA1a (also known as ATP2A1) in complex with SLN at 3.1 A resolution. The regulatory SLN traps the Ca(2+)-ATPase in a previously undescribed E1 state, with exposure of the Ca(2+) sites through an open cytoplasmic pathway stabilized by Mg(2+). The structure suggests a mechanism for selective Ca(2+) loading and activation of SERCA, and provides new insight into how SLN and PLB inhibition arises from stabilization of this E1 intermediate state without bound Ca(2+). These findings may prove useful in studying how autoinhibitory domains of other ion pumps modulate transport across biological membranes.

-	~~==About this Structure==~~	+	The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm.,Winther AM, Bublitz M, Karlsen JL, Moller JV, Hansen JB, Nissen P, Buch-Pedersen MJ Nature. 2013 Mar 14;495(7440):265-9. doi: 10.1038/nature11900. Epub 2013 Mar 3. PMID:23455424<ref>PMID:23455424</ref>
-	~~[[4h1w]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki~~/~~Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4H1W OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Bublitz, M.]]	+	[[Category: Bublitz, M]]
-	[[Category: Buch-Pedersen, M J.]]	+	[[Category: Buch-Pedersen, M J]]
-	[[Category: Hansen, J B.]]	+	[[Category: Hansen, J B]]
-	[[Category: Karlsen, J.]]	+	[[Category: Karlsen, J]]
-	[[Category: Moller, J V.]]	+	[[Category: Moller, J V]]
-	[[Category: Nissen, P.]]	+	[[Category: Nissen, P]]
-	[[Category: Winther, A M.L.]]	+	[[Category: Winther, A M.L]]
	[[Category: Ca2+ transport]]		[[Category: Ca2+ transport]]
	[[Category: Hydrolase-hydrolase regulator complex]]		[[Category: Hydrolase-hydrolase regulator complex]]

OCA at 07:34, 27 March 2013

OCA — Wed, 27 Mar 2013 07:34:25 GMT

←Older revision		Revision as of 07:34, 27 March 2013
Line 1:		Line 1:
-	[[Image:4h1w.jpg\|left\|200px]]
-
	{{STRUCTURE_4h1w\| PDB=4h1w \| SCENE= }}		{{STRUCTURE_4h1w\| PDB=4h1w \| SCENE= }}
-
	===E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin===		===E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin===
-		+	{{ABSTRACT_PUBMED_23455424}}

	==About this Structure==		==About this Structure==

OCA at 14:26, 6 March 2013

OCA — Wed, 06 Mar 2013 14:26:55 GMT

←Older revision		Revision as of 14:26, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4h1w.jpg\|left\|200px]]

-	~~The entry~~ 4h1w ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4h1w\| PDB=4h1w \| SCENE= }}

-	~~Authors: Bublitz, M., Winther, A.~~-~~M.L., Karlsen, J., Moller, J.V., Hansen, J.B., Buch-Pedersen, M.J., Nissen, P.~~	+	===E1 structure of the (SR) Ca2+-ATPase in complex with Sarcolipin===

-	~~Description~~: ~~Inhibitor bound~~ Ca2+-~~ATPase~~	+
		+	==About this Structure==
		+	[[4h1w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H1W OCA].
		+	[[Category: Calcium-transporting ATPase]]
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Bublitz, M.]]
		+	[[Category: Buch-Pedersen, M J.]]
		+	[[Category: Hansen, J B.]]
		+	[[Category: Karlsen, J.]]
		+	[[Category: Moller, J V.]]
		+	[[Category: Nissen, P.]]
		+	[[Category: Winther, A M.L.]]
		+	[[Category: Ca2+ transport]]
		+	[[Category: Hydrolase-hydrolase regulator complex]]
		+	[[Category: Membrane protein]]
		+	[[Category: P-type atpase]]
		+	[[Category: Phospholamban]]
		+	[[Category: Sarcolipin]]

OCA at 20:10, 26 September 2012

OCA — Wed, 26 Sep 2012 20:10:48 GMT

←Older revision		Revision as of 20:10, 26 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h1w is ON HOLD	+	The entry 4h1w is ON HOLD until Paper Publication

	Authors: Bublitz, M., Winther, A.-M.L., Karlsen, J., Moller, J.V., Hansen, J.B., Buch-Pedersen, M.J., Nissen, P.		Authors: Bublitz, M., Winther, A.-M.L., Karlsen, J., Moller, J.V., Hansen, J.B., Buch-Pedersen, M.J., Nissen, P.

	Description: Inhibitor bound Ca2+-ATPase		Description: Inhibitor bound Ca2+-ATPase

OCA: Protected "4h1w" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2012 06:57:55 GMT

Protected "4h1w" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:57, 19 September 2012