4h36 - Revision history

OCA at 14:59, 20 September 2023

OCA — Wed, 20 Sep 2023 14:59:14 GMT

←Older revision		Revision as of 14:59, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H36 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H36 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [https://pdbe.org/4h36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [https://www.ebi.ac.uk/pdbsum/4h36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h36 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [https://pdbe.org/4h36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [https://www.ebi.ac.uk/pdbsum/4h36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h36 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 07:57, 3 November 2022

OCA — Thu, 03 Nov 2022 07:57:15 GMT

←Older revision		Revision as of 07:57, 3 November 2022
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	==Crystal Structure of JNK3 in Complex with ATF2 Peptide==		==Crystal Structure of JNK3 in Complex with ATF2 Peptide==
-	<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4h36' size='340' side='right'caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H36 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h39\|4h39]], [[4h3b\|4h3b]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [https://pdbe.org/4h36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [https://www.ebi.ac.uk/pdbsum/4h36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h36 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [~~http~~://pdbe.org/4h36 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h36 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h36 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[~~http~~://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.	+	[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref> [[http://www.uniprot.org/uniprot/ATF2_HUMAN ATF2_HUMAN]] Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.	+	[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4h36" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4h36" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mitogen-activated protein kinase 3D structures\|Mitogen-activated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Mitogen-activated protein kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Cherry, L]]	+	[[Category: Cherry L]]
-	[[Category: Figuera-Losada, M]]	+	[[Category: Figuera-Losada M]]
-	[[Category: Laughlin~~, J D~~]]	+	[[Category: Laughlin JD]]
-	[[Category: LoGrasso~~, P V~~]]	+	[[Category: LoGrasso PV]]
-	[[Category: Nettles~~, K W~~]]	+	[[Category: Nettles KW]]
-	[[Category: Nwachukwu~~, J C]]~~	+	[[Category: Nwachukwu JC]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:35, 15 November 2017

OCA — Wed, 15 Nov 2017 08:35:15 GMT

←Older revision		Revision as of 08:35, 15 November 2017
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	</div>		</div>
	<div class="pdbe-citations 4h36" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4h36" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:09, 22 March 2017

OCA — Wed, 22 Mar 2017 17:09:25 GMT

←Older revision		Revision as of 17:09, 22 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of JNK3 in Complex with ATF2 Peptide==		==Crystal Structure of JNK3 in Complex with ATF2 Peptide==
	<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [http://www.ebi.ac.uk/pdbsum/4h36 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [http://pdbe.org/4h36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [http://www.ebi.ac.uk/pdbsum/4h36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h36 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h36" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:09, 17 June 2015

OCA — Wed, 17 Jun 2015 09:09:41 GMT

←Older revision		Revision as of 09:09, 17 June 2015
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	<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H36 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h39\|4h39]], [[4h3b\|4h3b]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h39\|4h39]], [[4h3b\|4h3b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [http://www.ebi.ac.uk/pdbsum/4h36 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [http://www.ebi.ac.uk/pdbsum/4h36 PDBsum]</span></td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Cherry, L]]		[[Category: Cherry, L]]

OCA at 14:18, 4 January 2015

OCA — Sun, 04 Jan 2015 14:18:01 GMT

←Older revision		Revision as of 14:18, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}~~	+	==Crystal Structure of JNK3 in Complex with ATF2 Peptide==
-	===Crystal Structure of JNK3 in Complex with ATF2 Peptide===	+	<StructureSection load='4h36' size='340' side='right' caption='[[4h36]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23142346}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H36 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4h39\|4h39]], [[4h3b\|4h3b]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">JNK3, JNK3A, MAPK10, PRKM10, SAPK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ATF2, CREB2, CREBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h36 RCSB], [http://www.ebi.ac.uk/pdbsum/4h36 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[http://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.		[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[http://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref> [[http://www.uniprot.org/uniprot/ATF2_HUMAN ATF2_HUMAN]] Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	c-Jun N-terminal (JNK) family kinases have a common peptide-docking site used by upstream activating kinases, substrates, scaffold proteins, and phosphatases, where the ensemble of bound proteins determines signaling output. Although there are many JNK structures, little is known about mechanisms of allosteric regulation between the catalytic and peptide-binding sites, and the activation loop, whose phosphorylation is required for catalytic activity. Here, we compare three structures of unliganded JNK3 bound to different peptides. These were compared as a class to structures that differ in binding of peptide, small molecule ligand, or conformation of the kinase activation loop. Peptide binding induced an inhibitory interlobe conformer that was reversed by alterations in the activation loop. Structure class analysis revealed the subtle structural mechanisms for allosteric signaling between the peptide-binding site and activation loop. Biochemical data from isothermal calorimetry, fluorescence energy transfer, and enzyme inhibition demonstrated affinity differences among the three peptides that were consistent with structural observations.

-	~~==Function==~~	+	Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.,Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, Lograsso PV Structure. 2012 Nov 6. pii: S0969-2126(12)00374-7. doi:, 10.1016/j.str.2012.09.021. PMID:23142346<ref>PMID:23142346</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine~~-~~protein kinase involved in various processes such as neuronal proliferation~~, ~~differentiation~~, ~~migration and programmed cell death~~. ~~Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress~~-~~activated protein kinase/c-Jun N-terminal kinase~~ (~~SAP/JNK~~) ~~signaling pathway~~. ~~In this cascade~~, ~~two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3~~. ~~In turn, MAPK10~~/~~JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity~~. ~~Plays regulatory roles in the signaling pathways during neuronal apoptosis~~. ~~Phosphorylates the neuronal microtubule regulator STMN2~~. ~~Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP~~. ~~Participates also in neurite growth in spiral ganglion neurons~~.<ref>PMID:~~11718727~~</ref> [[http://www.uniprot.org/uniprot/ATF2_HUMAN ATF2_HUMAN]] Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4h36]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
-	[[Category: Cherry, L.]]	+	[[Category: Cherry, L]]
-	[[Category: Figuera-Losada, M.]]	+	[[Category: Figuera-Losada, M]]
-	[[Category: Laughlin, J D.]]	+	[[Category: Laughlin, J D]]
-	[[Category: LoGrasso, P V.]]	+	[[Category: LoGrasso, P V]]
-	[[Category: Nettles, K W.]]	+	[[Category: Nettles, K W]]
-	[[Category: Nwachukwu, J C.]]	+	[[Category: Nwachukwu, J C]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 00:38, 25 March 2013

OCA — Mon, 25 Mar 2013 00:38:50 GMT

←Older revision		Revision as of 00:38, 25 March 2013
Line 1:		Line 1:
-	[[Image:4h36.png\|left\|200px]]
-
	{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}		{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}
-
	===Crystal Structure of JNK3 in Complex with ATF2 Peptide===		===Crystal Structure of JNK3 in Complex with ATF2 Peptide===
-
	{{ABSTRACT_PUBMED_23142346}}		{{ABSTRACT_PUBMED_23142346}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[http://omim.org/entry/606369 606369]]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN]] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref> [[http://www.uniprot.org/uniprot/ATF2_HUMAN ATF2_HUMAN]] Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.

	==About this Structure==		==About this Structure==
	[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA].		[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]

OCA at 14:32, 28 November 2012

OCA — Wed, 28 Nov 2012 14:32:59 GMT

←Older revision		Revision as of 14:32, 28 November 2012
Line 1:		Line 1:
-	[[Image:4h36.~~jpg~~\|left\|200px]]	+	[[Image:4h36.png\|left\|200px]]

	{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}		{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}
Line 5:		Line 5:
	===Crystal Structure of JNK3 in Complex with ATF2 Peptide===		===Crystal Structure of JNK3 in Complex with ATF2 Peptide===

		+	{{ABSTRACT_PUBMED_23142346}}

	==About this Structure==		==About this Structure==

OCA at 09:47, 21 November 2012

OCA — Wed, 21 Nov 2012 09:47:59 GMT

←Older revision		Revision as of 09:47, 21 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4h36.jpg\|left\|200px]]

-	~~The entry~~ 4h36 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4h36\| PDB=4h36 \| SCENE= }}

-	~~Authors: Nwachukwu, J.C., Laughlin, J.D., Figuera-Losada, M., Cherry, L., Nettles, K.W., LoGrasso, P.V.~~	+	===Crystal Structure of JNK3 in Complex with ATF2 Peptide===

-	~~Description: Crystal~~ Structure ~~of JNK3 in Complex~~ with ~~ATF2 Peptide~~	+
		+	==About this Structure==
		+	[[4h36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H36 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Mitogen-activated protein kinase]]
		+	[[Category: Cherry, L.]]
		+	[[Category: Figuera-Losada, M.]]
		+	[[Category: Laughlin, J D.]]
		+	[[Category: LoGrasso, P V.]]
		+	[[Category: Nettles, K W.]]
		+	[[Category: Nwachukwu, J C.]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]

OCA at 06:55, 10 October 2012

OCA — Wed, 10 Oct 2012 06:55:30 GMT

←Older revision		Revision as of 06:55, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h36 is ON HOLD	+	The entry 4h36 is ON HOLD until Paper Publication

-	Authors: ~~Laughlin~~, J.D., ~~Nwachukwu~~, J.C., Figuera-Losada, M., Cherry, L., Nettles, K.W., LoGrasso, P.V.	+	Authors: Nwachukwu, J.C., Laughlin, J.D., Figuera-Losada, M., Cherry, L., Nettles, K.W., LoGrasso, P.V.

	Description: Crystal Structure of JNK3 in Complex with ATF2 Peptide		Description: Crystal Structure of JNK3 in Complex with ATF2 Peptide