4h7q - Revision history

OCA at 11:35, 1 March 2024

OCA — Fri, 01 Mar 2024 11:35:52 GMT

←Older revision		Revision as of 11:35, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [https://pdbe.org/4h7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [https://www.ebi.ac.uk/pdbsum/4h7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [https://pdbe.org/4h7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [https://www.ebi.ac.uk/pdbsum/4h7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.		[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by the specific BCKD kinase (BDK). Here, we used structure-based design to develop a BDK inhibitor, (S)-alpha-chloro-phenylpropionic acid [(S)-CPP]. Crystal structures of the BDK-(S)-CPP complex show that (S)-CPP binds to a unique allosteric site in the N-terminal domain, triggering helix movements in BDK. These conformational changes are communicated to the lipoyl-binding pocket, which nullifies BDK activity by blocking its binding to the BCKDC core. Administration of (S)-CPP to mice leads to the full activation and dephosphorylation of BCKDC with significant reduction in plasma BCAA concentrations. The results buttress the concept of targeting mitochondrial BDK as a pharmacological approach to mitigate BCAA accumulation in metabolic diseases and heart failure.
-
-	Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.,Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi:, 10.1073/pnas.1303220110. Epub 2013 May 28. PMID:23716694<ref>PMID:23716694</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4h7q" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 3 November 2022

OCA — Thu, 03 Nov 2022 08:04:07 GMT

←Older revision		Revision as of 08:04, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP==		==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP==
-	<StructureSection load='4h7q' size='340' side='right' caption='[[4h7q]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4h7q' size='340' side='right'caption='[[4h7q]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tz4\|3tz4]], [[4dzy\|4dzy]], [[3tz5\|3tz5]], [[4e00\|4e00]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [https://pdbe.org/4h7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [https://www.ebi.ac.uk/pdbsum/4h7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7q ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [~~http~~://pdbe.org/4h7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.	+	[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by the specific BCKD kinase (BDK). Here, we used structure-based design to develop a BDK inhibitor, (S)-alpha-chloro-phenylpropionic acid [(S)-CPP]. Crystal structures of the BDK-(S)-CPP complex show that (S)-CPP binds to a unique allosteric site in the N-terminal domain, triggering helix movements in BDK. These conformational changes are communicated to the lipoyl-binding pocket, which nullifies BDK activity by blocking its binding to the BCKDC core. Administration of (S)-CPP to mice leads to the full activation and dephosphorylation of BCKDC with significant reduction in plasma BCAA concentrations. The results buttress the concept of targeting mitochondrial BDK as a pharmacological approach to mitigate BCAA accumulation in metabolic diseases and heart failure.
		+
		+	Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.,Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi:, 10.1073/pnas.1303220110. Epub 2013 May 28. PMID:23716694<ref>PMID:23716694</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4h7q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chuang, D T~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Chuang~~, J L~~]]	+	[[Category: Chuang DT]]
-	[[Category: ~~Gui, W J~~]]	+	[[Category: Chuang JL]]
-	[[Category: ~~Li, J~~]]	+	[[Category: Gui WJ]]
-	[[Category: ~~Tso, S C~~]]	+	[[Category: Li J]]
-	[[Category: ~~Wynn, R M~~]]	+	[[Category: Tso SC]]
-	[[Category: ~~Allosteric kinase inhibitor]]~~	+	[[Category: Wynn RM]]
-	~~[[Category: Bergerat nucleotide-binding fold]]~~	+
-	~~[[Category: Branched-chain alpha-ketoacid]]~~	+
-	~~[[Category: Branched-chain amino acid]]~~	+
-	~~[[Category: Diabetes and obesity]]~~	+
-	~~[[Category: Ghkl protein kinase]]~~	+
-	~~[[Category: Maple syrup urine disease]]~~	+
-	~~[[Category: Protein kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 20:49, 4 August 2016

OCA — Thu, 04 Aug 2016 20:49:07 GMT

←Older revision		Revision as of 20:49, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP==		==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP==
	<StructureSection load='4h7q' size='340' side='right' caption='[[4h7q]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4h7q' size='340' side='right' caption='[[4h7q]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tz4\|3tz4]], [[4dzy\|4dzy]], [[3tz5\|3tz5]], [[4e00\|4e00]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tz4\|3tz4]], [[4dzy\|4dzy]], [[3tz5\|3tz5]], [[4e00\|4e00]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [http://www.ebi.ac.uk/pdbsum/4h7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [http://pdbe.org/4h7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [http://www.ebi.ac.uk/pdbsum/4h7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Chuang, D T]]		[[Category: Chuang, D T]]
	[[Category: Chuang, J L]]		[[Category: Chuang, J L]]

OCA at 19:31, 24 December 2014

OCA — Wed, 24 Dec 2014 19:31:38 GMT

←Older revision		Revision as of 19:31, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4h7q\| PDB=4h7q \| SCENE= }}~~	+	==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP==
-	===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP===	+	<StructureSection load='4h7q' size='340' side='right' caption='[[4h7q]], [[Resolution\|resolution]] 2.10Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4h7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tz4\|3tz4]], [[4dzy\|4dzy]], [[3tz5\|3tz5]], [[4e00\|4e00]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h7q RCSB], [http://www.ebi.ac.uk/pdbsum/4h7q PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.		[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[4h7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/~~ocashort?id=4H7Q OCA].~~	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chuang, D T.]]	+	[[Category: Chuang, D T]]
-	[[Category: Chuang, J L.]]	+	[[Category: Chuang, J L]]
-	[[Category: Gui, W J.]]	+	[[Category: Gui, W J]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Tso, S C.]]	+	[[Category: Tso, S C]]
-	[[Category: Wynn, R M.]]	+	[[Category: Wynn, R M]]
	[[Category: Allosteric kinase inhibitor]]		[[Category: Allosteric kinase inhibitor]]
	[[Category: Bergerat nucleotide-binding fold]]		[[Category: Bergerat nucleotide-binding fold]]

OCA at 18:13, 19 June 2013

OCA — Wed, 19 Jun 2013 18:13:42 GMT

←Older revision		Revision as of 18:13, 19 June 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4h7q\| PDB=4h7q \| SCENE= }}
		+	===Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP===

-	~~The entry 4h7q is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.

-	~~Authors~~: ~~Tso, S~~.C., Chuang, J.L., Gui, W.J., Wynn, R.M.~~, Li, J., Chuang, D.T.~~	+	==About this Structure==
-		+	[[4h7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Q OCA].
-	~~Description~~: ~~Crystal structure of branched~~-chain alpha-ketoacid ~~dehydrogenase kinase/ alpha~~-~~ketoisocaproic~~ acid complex ~~with ADP~~	+	[[Category: Rattus norvegicus]]
		+	[[Category: Chuang, D T.]]
		+	[[Category: Chuang, J L.]]
		+	[[Category: Gui, W J.]]
		+	[[Category: Li, J.]]
		+	[[Category: Tso, S C.]]
		+	[[Category: Wynn, R M.]]
		+	[[Category: Allosteric kinase inhibitor]]
		+	[[Category: Bergerat nucleotide-binding fold]]
		+	[[Category: Branched-chain alpha-ketoacid]]
		+	[[Category: Branched-chain amino acid]]
		+	[[Category: Diabetes and obesity]]
		+	[[Category: Ghkl protein kinase]]
		+	[[Category: Maple syrup urine disease]]
		+	[[Category: Protein kinase]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:08, 24 October 2012

OCA — Wed, 24 Oct 2012 07:08:11 GMT

←Older revision		Revision as of 07:08, 24 October 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h7q is ON HOLD	+	The entry 4h7q is ON HOLD until Paper Publication

-	Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R. M., Li, J., Chuang, D. T.	+	Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R.M., Li, J., Chuang, D.T.

	Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/ alpha-ketoisocaproic acid complex with ADP		Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/ alpha-ketoisocaproic acid complex with ADP

OCA: Protected "4h7q" [edit=sysop:move=sysop]

OCA — Wed, 26 Sep 2012 20:15:27 GMT

Protected "4h7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:15, 26 September 2012

OCA: New page: '''Unreleased structure''' The entry 4h7q is ON HOLD Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R. M., Li, J., Chuang, D. T. Description: Crystal structure of branched-chain al...

OCA — Wed, 26 Sep 2012 20:15:26 GMT

New page: '''Unreleased structure''' The entry 4h7q is ON HOLD Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R. M., Li, J., Chuang, D. T. Description: Crystal structure of branched-chain al...

New page

'''Unreleased structure'''

The entry 4h7q is ON HOLD

Authors: Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R. M., Li, J., Chuang, D. T.

Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/ alpha-ketoisocaproic acid complex with ADP