4h96 - Revision history

OCA at 15:01, 20 September 2023

OCA — Wed, 20 Sep 2023 15:01:55 GMT

←Older revision		Revision as of 15:01, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4h96]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H96 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4h96]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [https://pdbe.org/4h96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [https://www.ebi.ac.uk/pdbsum/4h96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h96 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [https://pdbe.org/4h96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [https://www.ebi.ac.uk/pdbsum/4h96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h96 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 04:31, 30 September 2022

OCA — Fri, 30 Sep 2022 04:31:29 GMT

←Older revision		Revision as of 04:31, 30 September 2022
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	==Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==		==Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
-	<StructureSection load='4h96' size='340' side='right' caption='[[4h96]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4h96' size='340' side='right'caption='[[4h96]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4h96]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4H96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4h96]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qls\|3qls]], [[3qlr\|3qlr]], [[3qlw\|3qlw]], [[3qly\|3qly]], [[3qlx\|3qlx]], [[3qlz\|3qlz]], [[4h95\|4h95]], [[4h97\|4h97]], [[4h98\|4h98]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [https://pdbe.org/4h96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [https://www.ebi.ac.uk/pdbsum/4h96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h96 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DFR1, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [~~http~~://pdbe.org/4h96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4h96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4h96 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	~~[[Category: Dihydrofolate reductase]]~~	+	[[Category: Candida albicans]]
-	~~[[Category: Anderson, A C]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Paulsen, J L]]~~	+	[[Category: Anderson AC]]
-	~~[[Category: Antifungal agent]]~~	+	[[Category: Paulsen JL]]
-	[[Category: Candida ~~albican~~]]	+
-	[[Category: ~~Drug design~~]]	+
-	[[Category: ~~Enzyme inhibitor~~]]	+
-	[[Category: ~~Fungal protein]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Tetrahydrofolate dehydrogenase~~]]	+

OCA at 09:19, 4 August 2016

OCA — Thu, 04 Aug 2016 09:19:49 GMT

←Older revision		Revision as of 09:19, 4 August 2016
Line 1:		Line 1:
		+
	==Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==		==Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
	<StructureSection load='4h96' size='340' side='right' caption='[[4h96]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4h96' size='340' side='right' caption='[[4h96]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DFR1, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DFR1, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [http://www.ebi.ac.uk/pdbsum/4h96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [http://pdbe.org/4h96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [http://www.ebi.ac.uk/pdbsum/4h96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h96 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4h96" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:33, 21 December 2014

OCA — Sun, 21 Dec 2014 11:33:32 GMT

←Older revision		Revision as of 11:33, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4h96\| PDB=4h96 \| SCENE= }}~~	+	==Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
-	===Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)===	+	<StructureSection load='4h96' size='340' side='right' caption='[[4h96]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23375226}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4h96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H96 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qls\|3qls]], [[3qlr\|3qlr]], [[3qlw\|3qlw]], [[3qly\|3qly]], [[3qlx\|3qlx]], [[3qlz\|3qlz]], [[4h95\|4h95]], [[4h97\|4h97]], [[4h98\|4h98]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DFR1, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h96 RCSB], [http://www.ebi.ac.uk/pdbsum/4h96 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel strategy for targeting the pathogenic organisms Candida albicans and Candida glabrata focuses on the development of potent and selective antifolates effective against dihydrofolate reductase. Crystal structure analysis suggested that an essential loop at the active site (Thr 58-Phe 66) differs from the analogous residues in the human enzyme, potentially providing a mechanism for achieving selectivity. In order to probe the role of this loop, we employed chemical synthesis, crystal structure determination and molecular dynamics simulations. The results of these analyses show that the loop residues undergo ligand-induced conformational changes that are similar among the fungal and human species.

-	~~==About this Structure==~~	+	Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.,Paulsen JL, Viswanathan K, Wright DL, Anderson AC Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226<ref>PMID:23375226</ref>
-	~~[[4h96]] is a 2 chain structure with sequence~~ from ~~[http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4H96 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023375226</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: Anderson, A C.]]	+	[[Category: Anderson, A C]]
-	[[Category: Paulsen, J L.]]	+	[[Category: Paulsen, J L]]
	[[Category: Antifungal agent]]		[[Category: Antifungal agent]]
	[[Category: Candida albican]]		[[Category: Candida albican]]

OCA at 11:55, 20 November 2013

OCA — Wed, 20 Nov 2013 11:55:07 GMT

←Older revision		Revision as of 11:55, 20 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4h96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans Candida albicans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA].	+	[[4h96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA].
-	[[~~Category: Candida albicans~~]]	+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023375226</ref><references group="xtra"/><references/>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Anderson, A C.]]		[[Category: Anderson, A C.]]

OCA at 08:44, 27 March 2013

OCA — Wed, 27 Mar 2013 08:44:50 GMT

←Older revision		Revision as of 08:44, 27 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4h96\| PDB=4h96 \| SCENE= }}
		+	===Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)===
		+	{{ABSTRACT_PUBMED_23375226}}

-	~~The entry~~ 4h96 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4h96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H96 OCA].
-	~~Authors~~: ~~Paulsen, J~~.L.~~, Anderson, A~~.C.	+	[[Category: Candida albicans]]
-		+	[[Category: Dihydrofolate reductase]]
-	~~Description~~: Candida albicans ~~dihydrofolate~~ reductase ~~complexed with NADPH and 5-{3-~~[~~3-(2~~,~~3-dihydro-1~~,~~4-benzodioxin-6-yl)-5-methoxyphenyl~~]~~prop-1-yn-1~~-~~yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)~~	+	[[Category: Anderson, A C.]]
		+	[[Category: Paulsen, J L.]]
		+	[[Category: Antifungal agent]]
		+	[[Category: Candida albican]]
		+	[[Category: Drug design]]
		+	[[Category: Enzyme inhibitor]]
		+	[[Category: Fungal protein]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Tetrahydrofolate dehydrogenase]]

OCA at 09:47, 13 March 2013

OCA — Wed, 13 Mar 2013 09:47:41 GMT

←Older revision		Revision as of 09:47, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4h96 is ON HOLD	+	The entry 4h96 is ON HOLD until Paper Publication

	Authors: Paulsen, J.L., Anderson, A.C.		Authors: Paulsen, J.L., Anderson, A.C.

	Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)		Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)

OCA: Protected "4h96" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2012 05:50:14 GMT

Protected "4h96" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4h96 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-...

OCA — Wed, 03 Oct 2012 05:50:13 GMT

New page: '''Unreleased structure''' The entry 4h96 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-...

New page

'''Unreleased structure'''

The entry 4h96 is ON HOLD

Authors: Paulsen, J.L., Anderson, A.C.

Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)