4hac - Revision history

OCA at 08:07, 3 November 2022

OCA — Thu, 03 Nov 2022 08:07:01 GMT

←Older revision		Revision as of 08:07, 3 November 2022
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	==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==		==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
-	<StructureSection load='4hac' size='340' side='right' caption='[[4hac]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='4hac' size='340' side='right'caption='[[4hac]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Metma Metma~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HAC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_Go1 Methanosarcina mazei Go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [https://pdbe.org/4hac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [https://www.ebi.ac.uk/pdbsum/4hac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hac ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MM_1762, MVK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192952 METMA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [~~http~~://pdbe.org/4hac PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hac PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hac ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q8PW39_METMA Q8PW39_METMA]] Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217]	+	[https://www.uniprot.org/uniprot/Q8PW39_METMA Q8PW39_METMA] Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hac" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hac" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mevalonate kinase\|Mevalonate kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Metma~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Mevalonate kinase~~]]	+	[[Category: Methanosarcina mazei Go1]]
-	[[Category: Lee~~, K H~~]]	+	[[Category: Lee KH]]
-	[[Category: Zhuang, N]]	+	[[Category: Zhuang N]]
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Ghmp]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 17:03, 4 August 2016

OCA — Thu, 04 Aug 2016 17:03:45 GMT

←Older revision		Revision as of 17:03, 4 August 2016
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		+
	==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==		==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
	<StructureSection load='4hac' size='340' side='right' caption='[[4hac]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4hac' size='340' side='right' caption='[[4hac]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methanosarcina_mazei_go1 Methanosarcina mazei go1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metma Metma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MM_1762, MVK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192952 ~~Methanosarcina mazei Go1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MM_1762, MVK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192952 METMA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://pdbe.org/4hac PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hac ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hac" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methanosarcina mazei go1~~]]	+	[[Category: Metma]]
	[[Category: Mevalonate kinase]]		[[Category: Mevalonate kinase]]
	[[Category: Lee, K H]]		[[Category: Lee, K H]]

OCA at 11:12, 25 December 2014

OCA — Thu, 25 Dec 2014 11:12:56 GMT

←Older revision		Revision as of 11:12, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q8PW39_METMA Q8PW39_METMA]] Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:22, 10 December 2014

OCA — Wed, 10 Dec 2014 09:22:13 GMT

←Older revision		Revision as of 09:22, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hac.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
		+	<StructureSection load='4hac' size='340' side='right' caption='[[4hac]], [[Resolution\|resolution]] 1.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei_go1 Methanosarcina mazei go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MM_1762, MVK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192952 Methanosarcina mazei Go1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mevalonate_kinase Mevalonate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.36 2.7.1.36] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [http://www.ebi.ac.uk/pdbsum/4hac PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mevalonate kinase (MVK), which plays an important role in catalysing the biosynthesis of isoprenoid compounds derived from the mevalonate pathway, transforms mevalonate to 5-phosphomevalonate using ATP as a cofactor. Mevalonate kinase from Methanosarcina mazei (MmMVK) was expressed in Escherichia coli, purified and crystallized for structural analysis. Diffraction-quality crystals of MmMVK were obtained by the vapour-diffusion method using 0.32 M MgCl(2), 0.08 M bis-tris pH 5.5, 16%(w/v) PEG 3350. The crystals belonged to space group P2(1)2(1)2, with unit-cell parameters a = 97.11, b = 135.92, c = 46.03 A. Diffraction data were collected to 2.08 A resolution.

-	~~{{STRUCTURE_4hac\| PDB=4hac \| SCENE= }}~~	+	Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei.,Zhuang N, Seo KH, Chen C, Zhou J, Kim SW, Lee KH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1560-3., doi: 10.1107/S1744309112047070. Epub 2012 Nov 28. PMID:23192048<ref>PMID:23192048</ref>

-	~~===Crystal Structure~~ of the ~~Mevalonate Kinase from an Archaeon Methanosarcina mazei===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23192048}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hac]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Methanosarcina_mazei_go1 Methanosarcina mazei go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA].~~	+	</StructureSection>
	[[Category: Methanosarcina mazei go1]]		[[Category: Methanosarcina mazei go1]]
	[[Category: Mevalonate kinase]]		[[Category: Mevalonate kinase]]
-	[[Category: Lee, K H.]]	+	[[Category: Lee, K H]]
-	[[Category: Zhuang, N.]]	+	[[Category: Zhuang, N]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Ghmp]]		[[Category: Ghmp]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:36, 19 December 2012

OCA — Wed, 19 Dec 2012 10:36:53 GMT

←Older revision		Revision as of 10:36, 19 December 2012
Line 1:		Line 1:
-	[[Image:4hac.~~jpg~~\|left\|200px]]	+	[[Image:4hac.png\|left\|200px]]

	{{STRUCTURE_4hac\| PDB=4hac \| SCENE= }}		{{STRUCTURE_4hac\| PDB=4hac \| SCENE= }}
Line 5:		Line 5:
	===Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei===		===Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei===

		+	{{ABSTRACT_PUBMED_23192048}}

	==About this Structure==		==About this Structure==

OCA at 21:27, 12 December 2012

OCA — Wed, 12 Dec 2012 21:27:37 GMT

←Older revision		Revision as of 21:27, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hac.jpg\|left\|200px]]

-	~~The entry~~ 4hac ~~is ON HOLD~~	+	{{STRUCTURE_4hac\| PDB=4hac \| SCENE= }}

-	~~Authors: Zhuang, N.~~	+	===Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei===

-	~~Description: Crystal~~ Structure ~~of the Mevalonate Kinase~~ from ~~an Archaeon~~ Methanosarcina mazei	+
		+	==About this Structure==
		+	[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei_go1 Methanosarcina mazei go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA].
		+	[[Category: Methanosarcina mazei go1]]
		+	[[Category: Mevalonate kinase]]
		+	[[Category: Lee, K H.]]
		+	[[Category: Zhuang, N.]]
		+	[[Category: Atp binding]]
		+	[[Category: Ghmp]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Transferase]]

OCA: Protected "4hac" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2012 05:51:26 GMT

Protected "4hac" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hac is ON HOLD Authors: Zhuang, N. Description: Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei

OCA — Wed, 03 Oct 2012 05:51:25 GMT

New page: '''Unreleased structure''' The entry 4hac is ON HOLD Authors: Zhuang, N. Description: Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei

New page

'''Unreleased structure'''

The entry 4hac is ON HOLD

Authors: Zhuang, N.

Description: Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei