4hav - Revision history

OCA at 08:07, 3 November 2022

OCA — Thu, 03 Nov 2022 08:07:47 GMT

←Older revision		Revision as of 08:07, 3 November 2022
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	==Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1==		==Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1==
-	<StructureSection load='4hav' size='340' side='right' caption='[[4hav]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4hav' size='340' side='right'caption='[[4hav]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hav]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hav]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA8:ANGUINOMYCIN+A,+BOUND+FORM'>AA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AA8:ANGUINOMYCIN+A,+BOUND+FORM'>AA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gmx\|4gmx]], [[4gpt\|4gpt]], [[4hat\|4hat]], [[4hau\|4hau]], [[4haw\|4haw]], [[4hax\|4hax]], [[4hay\|4hay]], [[4haz\|4haz]], [[4hb0\|4hb0]], [[4hb2\|4hb2]], [[4hb3\|4hb3]], [[4hb4\|4hb4]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [https://pdbe.org/4hav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [https://www.ebi.ac.uk/pdbsum/4hav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hav ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [~~http~~://pdbe.org/4hav PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hav PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hav ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.	+	[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hav" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hav" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Exportin 3D structures\|Exportin 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chook, Y M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Sun, Q~~]]	+	[[Category: Chook YM]]
-	[[Category: ~~Anguinomycin some]]~~	+	[[Category: Sun Q]]
-	~~[[Category: Heat repeat]]~~	+
-	~~[[Category: Nuclear export]]~~	+
-	~~[[Category: Protein transport-antibiotic complex]]~~	+
-	~~[[Category: Ran-ranbp1~~]]	+

OCA at 05:34, 16 November 2017

OCA — Thu, 16 Nov 2017 05:34:34 GMT

←Older revision		Revision as of 05:34, 16 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4hav" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hav" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Exportin\|Exportin]]
-	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:09, 4 August 2016

OCA — Thu, 04 Aug 2016 21:09:18 GMT

←Older revision		Revision as of 21:09, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1==		==Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1==
	<StructureSection load='4hav' size='340' side='right' caption='[[4hav]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4hav' size='340' side='right' caption='[[4hav]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hav]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hav]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA8:ANGUINOMYCIN+A,+BOUND+FORM'>AA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA8:ANGUINOMYCIN+A,+BOUND+FORM'>AA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gmx\|4gmx]], [[4gpt\|4gpt]], [[4hat\|4hat]], [[4hau\|4hau]], [[4haw\|4haw]], [[4hax\|4hax]], [[4hay\|4hay]], [[4haz\|4haz]], [[4hb0\|4hb0]], [[4hb2\|4hb2]], [[4hb3\|4hb3]], [[4hb4\|4hb4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gmx\|4gmx]], [[4gpt\|4gpt]], [[4hat\|4hat]], [[4hau\|4hau]], [[4haw\|4haw]], [[4hax\|4hax]], [[4hay\|4hay]], [[4haz\|4haz]], [[4hb0\|4hb0]], [[4hb2\|4hb2]], [[4hb3\|4hb3]], [[4hb4\|4hb4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [http://www.ebi.ac.uk/pdbsum/4hav PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [http://pdbe.org/4hav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [http://www.ebi.ac.uk/pdbsum/4hav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hav ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hav" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Atcc 18824]]
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Human]]
	[[Category: Chook, Y M]]		[[Category: Chook, Y M]]
	[[Category: Sun, Q]]		[[Category: Sun, Q]]

OCA at 13:10, 25 December 2014

OCA — Thu, 25 Dec 2014 13:10:56 GMT

←Older revision		Revision as of 13:10, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [http://www.ebi.ac.uk/pdbsum/4hav PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [http://www.ebi.ac.uk/pdbsum/4hav PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:02, 10 December 2014

OCA — Wed, 10 Dec 2014 09:02:46 GMT

←Older revision		Revision as of 09:02, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hav.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1==
		+	<StructureSection load='4hav' size='340' side='right' caption='[[4hav]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hav]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AA8:ANGUINOMYCIN+A,+BOUND+FORM'>AA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gmx\|4gmx]], [[4gpt\|4gpt]], [[4hat\|4hat]], [[4hau\|4hau]], [[4haw\|4haw]], [[4hax\|4hax]], [[4hay\|4hay]], [[4haz\|4haz]], [[4hb0\|4hb0]], [[4hb2\|4hb2]], [[4hb3\|4hb3]], [[4hb4\|4hb4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CRM1, KAP124, XPO1, YGR218W, G8514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hav RCSB], [http://www.ebi.ac.uk/pdbsum/4hav PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we present 1.8- to 2.0-A-resolution crystal structures of CRM1 bound to Leptomycin B and related inhibitors Anguinomycin A and Ratjadone A. Structural and complementary chemical analyses reveal an unexpected mechanism of inhibition involving covalent conjugation and CRM1-mediated hydrolysis of the natural products' lactone rings. Furthermore, mutagenesis reveals the mechanism of hydrolysis by CRM1. The nuclear export signal (NES)-binding groove of CRM1 is able to drive a chemical reaction in addition to binding protein cargos for transport through the nuclear pore complex.

-	~~{{STRUCTURE_4hav\| PDB=4hav \| SCENE= }}~~	+	Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.,Sun Q, Carrasco YP, Hu Y, Guo X, Mirzaei H, Macmillan J, Chook YM Proc Natl Acad Sci U S A. 2013 Jan 7. PMID:23297231<ref>PMID:23297231</ref>

-	~~===Crystal structure~~ of ~~CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23297231}}~~	+	==See Also==
-		+	*[[Exportin\|Exportin]]
-	==~~About this Structure~~==	+	*[[GTP-binding protein\|GTP-binding protein]]
-	[[~~4hav~~]] ~~is a 3 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and~~ [~~http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]~~. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA].~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Chook, Y M.]]	+	[[Category: Chook, Y M]]
-	[[Category: Sun, Q.]]	+	[[Category: Sun, Q]]
	[[Category: Anguinomycin some]]		[[Category: Anguinomycin some]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]

OCA at 11:31, 23 January 2013

OCA — Wed, 23 Jan 2013 11:31:25 GMT

←Older revision		Revision as of 11:31, 23 January 2013
Line 1:		Line 1:
-	[[Image:4hav.~~jpg~~\|left\|200px]]	+	[[Image:4hav.png\|left\|200px]]

	{{STRUCTURE_4hav\| PDB=4hav \| SCENE= }}		{{STRUCTURE_4hav\| PDB=4hav \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1===		===Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1===

		+	{{ABSTRACT_PUBMED_23297231}}

	==About this Structure==		==About this Structure==

OCA at 08:24, 9 January 2013

OCA — Wed, 09 Jan 2013 08:24:05 GMT

←Older revision		Revision as of 08:24, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hav.jpg\|left\|200px]]

-	~~The entry~~ 4hav ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hav\| PDB=4hav \| SCENE= }}

-	~~Authors: Sun, Q., Chook, Y.M.~~	+	===Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1===

-	~~Description~~:	+
		+	==About this Structure==
		+	[[4hav]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAV OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Chook, Y M.]]
		+	[[Category: Sun, Q.]]
		+	[[Category: Anguinomycin some]]
		+	[[Category: Heat repeat]]
		+	[[Category: Nuclear export]]
		+	[[Category: Protein transport-antibiotic complex]]
		+	[[Category: Ran-ranbp1]]

OCA at 13:20, 8 November 2012

OCA — Thu, 08 Nov 2012 13:20:50 GMT

←Older revision		Revision as of 13:20, 8 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hav is ON HOLD	+	The entry 4hav is ON HOLD until Paper Publication

	Authors: Sun, Q., Chook, Y.M.		Authors: Sun, Q., Chook, Y.M.

-	Description: ~~CRM1 inhibitor (2.0 A)~~	+	Description:

OCA at 07:08, 24 October 2012

OCA — Wed, 24 Oct 2012 07:08:50 GMT

←Older revision		Revision as of 07:08, 24 October 2012
Line 5:		Line 5:
	Authors: Sun, Q., Chook, Y.M.		Authors: Sun, Q., Chook, Y.M.

-	Description: CRM1 inhibitor (2.0 A )	+	Description: CRM1 inhibitor (2.0 A)

OCA: Protected "4hav" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2012 05:51:59 GMT

Protected "4hav" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 3 October 2012