4hbd - Revision history

OCA at 11:36, 1 March 2024

OCA — Fri, 01 Mar 2024 11:36:29 GMT

←Older revision		Revision as of 11:36, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.72Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [https://pdbe.org/4hbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [https://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [https://pdbe.org/4hbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [https://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:08, 3 November 2022

OCA — Thu, 03 Nov 2022 08:08:39 GMT

←Older revision		Revision as of 08:08, 3 November 2022
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	==Crystal structure of KANK2 ankyrin repeats==		==Crystal structure of KANK2 ankyrin repeats==
-	<StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution\|resolution]] 1.72Å' scene=''>	+	<StructureSection load='4hbd' size='340' side='right'caption='[[4hbd]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [https://pdbe.org/4hbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [https://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [~~http~~://pdbe.org/4hbd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN]] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>	+	[https://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>
		+
		+	==See Also==
		+	*[[Ankyrin repeat domain-containing protein 3D structures\|Ankyrin repeat domain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Arrowsmith, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bakkouri, M El~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Cerovina, T]]	+	[[Category: Cerovina T]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: ~~Min, J~~]]	+	[[Category: El Bakkouri M]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Min J]]
-	[[Category: Tempel, W]]	+	[[Category: Tempel W]]
-	[[Category: Xu, C]]	+	[[Category: Xu C]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 06:34, 5 August 2016

OCA — Fri, 05 Aug 2016 06:34:38 GMT

←Older revision		Revision as of 06:34, 5 August 2016
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		+
	==Crystal structure of KANK2 ankyrin repeats==		==Crystal structure of KANK2 ankyrin repeats==
	<StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://pdbe.org/4hbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bakkouri, M El]]		[[Category: Bakkouri, M El]]

OCA at 23:53, 24 December 2014

OCA — Wed, 24 Dec 2014 23:53:45 GMT

←Older revision		Revision as of 23:53, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN]] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:02, 10 December 2014

OCA — Wed, 10 Dec 2014 09:02:38 GMT

←Older revision		Revision as of 09:02, 10 December 2014
Line 1:		Line 1:
-	~~[[Image:4hbd.jpg\|left\|200px]]~~	+	==Crystal structure of KANK2 ankyrin repeats==
-		+	<StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution\|resolution]] 1.72Å' scene=''>
-	~~{{STRUCTURE_4hbd\| PDB=4hbd \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBD FirstGlance]. <br>
-	===Crystal structure of KANK2 ankyrin repeats===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KANK2, ANKRD25, KIAA1518, MXRA3, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	</table>
-	[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA].	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bakkouri, M El.]]	+	[[Category: Bakkouri, M El]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Cerovina, T.]]	+	[[Category: Cerovina, T]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Xu, C.]]	+	[[Category: Xu, C]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]

OCA at 21:27, 12 December 2012

OCA — Wed, 12 Dec 2012 21:27:39 GMT

←Older revision		Revision as of 21:27, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hbd.jpg\|left\|200px]]

-	~~The entry~~ 4hbd ~~is ON HOLD~~	+	{{STRUCTURE_4hbd\| PDB=4hbd \| SCENE= }}

-	~~Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)~~	+	===Crystal structure of KANK2 ankyrin repeats===

-	~~Description: Crystal~~ structure ~~of KANK2 ankyrin repeats~~	+
		+	==About this Structure==
		+	[[4hbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bakkouri, M El.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Cerovina, T.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Min, J.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Xu, C.]]
		+	[[Category: Protein binding]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomics consortium]]

OCA at 06:58, 10 October 2012

OCA — Wed, 10 Oct 2012 06:58:23 GMT

←Older revision		Revision as of 06:58, 10 October 2012
Line 3:		Line 3:
	The entry 4hbd is ON HOLD		The entry 4hbd is ON HOLD

-	Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Genomics Consortium (SGC)	+	Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)

	Description: Crystal structure of KANK2 ankyrin repeats		Description: Crystal structure of KANK2 ankyrin repeats

OCA: Protected "4hbd" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2012 05:52:28 GMT

Protected "4hbd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 3 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hbd is ON HOLD Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Geno...

OCA — Wed, 03 Oct 2012 05:52:27 GMT

New page: '''Unreleased structure''' The entry 4hbd is ON HOLD Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Geno...

New page

'''Unreleased structure'''

The entry 4hbd is ON HOLD

Authors: Xu, C., Tempel, W., Cerovina, T., El Bakkouri, M., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Genomics Consortium (SGC)

Description: Crystal structure of KANK2 ankyrin repeats