4hbx - Revision history

OCA at 15:03, 20 September 2023

OCA — Wed, 20 Sep 2023 15:03:08 GMT

←Older revision		Revision as of 15:03, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.62Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [https://pdbe.org/4hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [https://www.ebi.ac.uk/pdbsum/4hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [https://pdbe.org/4hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [https://www.ebi.ac.uk/pdbsum/4hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:09, 3 November 2022

OCA — Thu, 03 Nov 2022 08:09:38 GMT

←Older revision		Revision as of 08:09, 3 November 2022
Line 1:		Line 1:

	==Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand==
-	<StructureSection load='4hbx' size='340' side='right' caption='[[4hbx]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='4hbx' size='340' side='right'caption='[[4hbx]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hby\|4hby]], [[4hbw\|4hbw]], [[4hbv\|4hbv]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [https://pdbe.org/4hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [https://www.ebi.ac.uk/pdbsum/4hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbx ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [~~http~~://pdbe.org/4hbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Arrowsmith, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Bunnage, M E~~]]	+	[[Category: Bountra C]]
-	[[Category: ~~Cook, A S~~]]	+	[[Category: Bunnage ME]]
-	[[Category: ~~Delft, F von~~]]	+	[[Category: Cook AS]]
-	[[Category: Edwards, A]]	+	[[Category: Edwards A]]
-	[[Category: Felletar, I]]	+	[[Category: Felletar I]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Fish~~, P V~~]]	+	[[Category: Fish PV]]
-	[[Category: Knapp, S]]	+	[[Category: Knapp S]]
-	[[Category: Owen~~, D R~~]]	+	[[Category: Owen DR]]
-	[[Category: Picaud, S]]	+	[[Category: Picaud S]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Von Delft F]]
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Cap]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Hunk1]]~~	+
-	~~[[Category: Mcap]]~~	+
-	~~[[Category: Mitotic chromosome associated protein]]~~	+
-	~~[[Category: Protein binding-inhibitor complex]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 08:29, 4 August 2016

OCA — Thu, 04 Aug 2016 08:29:23 GMT

←Older revision		Revision as of 08:29, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand==
	<StructureSection load='4hbx' size='340' side='right' caption='[[4hbx]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='4hbx' size='340' side='right' caption='[[4hbx]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hby\|4hby]], [[4hbw\|4hbw]], [[4hbv\|4hbv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hby\|4hby]], [[4hbw\|4hbw]], [[4hbv\|4hbv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [http://www.ebi.ac.uk/pdbsum/4hbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [http://pdbe.org/4hbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [http://www.ebi.ac.uk/pdbsum/4hbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hbx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 12:03, 21 December 2014

OCA — Sun, 21 Dec 2014 12:03:40 GMT

←Older revision		Revision as of 12:03, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}~~	+	==Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand==
-	===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===	+	<StructureSection load='4hbx' size='340' side='right' caption='[[4hbx]], [[Resolution\|resolution]] 1.62Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23095041}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HBX FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14X:3-METHYL-6-(PYRROLIDIN-1-YLSULFONYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>14X</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hby\|4hby]], [[4hbw\|4hbw]], [[4hbv\|4hbv]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbx RCSB], [http://www.ebi.ac.uk/pdbsum/4hbx PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The posttranslational modification of chromatin through acetylation at selected histone lysine residues is governed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The significance of this subset of the epigenetic code is interrogated and interpreted by an acetyllysine-specific protein-protein interaction with bromodomain reader modules. Selective inhibition of the bromo and extra C-terminal domain (BET) family of bromodomains with a small molecule is feasible, and this may represent an opportunity for disease intervention through the recently disclosed antiproliferative and anti-inflammatory properties of such inhibitors. Herein, we describe the discovery and structure-activity relationship (SAR) of a novel, small-molecule chemical probe for BET family inhibition that was identified through the application of structure-based fragment assessment and optimization techniques. This has yielded a potent, selective compound with cell-based activity (PFI-1) that may further add to the understanding of BET family function within the bromodomains.

-	~~==About this Structure==~~	+	Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.,Fish PV, Filippakopoulos P, Bish G, Brennan PE, Bunnage ME, Cook AS, Federov O, Gerstenberger BS, Jones H, Knapp S, Marsden B, Nocka K, Owen DR, Philpott M, Picaud S, Primiano MJ, Ralph MJ, Sciammetta N, Trzupek JD J Med Chem. 2012 Nov 8. PMID:23095041<ref>PMID:23095041</ref>
-	~~[[4hbx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Bunnage, M E.]]	+	[[Category: Bunnage, M E]]
-	[[Category: Cook, A S.]]	+	[[Category: Cook, A S]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Felletar, I.]]	+	[[Category: Felletar, I]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Fish, P V.]]	+	[[Category: Fish, P V]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Owen, D R.]]	+	[[Category: Owen, D R]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: Qi, J.]]	+	[[Category: Qi, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Cap]]		[[Category: Cap]]
Line 37:		Line 47:
	[[Category: Protein binding-inhibitor complex]]		[[Category: Protein binding-inhibitor complex]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]

OCA at 10:36, 24 March 2013

OCA — Sun, 24 Mar 2013 10:36:37 GMT

←Older revision		Revision as of 10:36, 24 March 2013
Line 1:		Line 1:
-	[[Image:4hbx.png\|left\|200px]]
-
	{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}		{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}
-
	===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===		===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===
-
	{{ABSTRACT_PUBMED_23095041}}		{{ABSTRACT_PUBMED_23095041}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

	==About this Structure==		==About this Structure==
	[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA].		[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA at 21:35, 12 December 2012

OCA — Wed, 12 Dec 2012 21:35:19 GMT

←Older revision		Revision as of 21:35, 12 December 2012
Line 5:		Line 5:
	===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===		===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===

		+	{{ABSTRACT_PUBMED_23095041}}

	==About this Structure==		==About this Structure==

OCA at 06:37, 14 November 2012

OCA — Wed, 14 Nov 2012 06:37:15 GMT

←Older revision		Revision as of 06:37, 14 November 2012
Line 1:		Line 1:
-	[[Image:4hbx.~~jpg~~\|left\|200px]]	+	[[Image:4hbx.png\|left\|200px]]

	{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}		{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}

OCA at 09:27, 31 October 2012

OCA — Wed, 31 Oct 2012 09:27:44 GMT

←Older revision		Revision as of 09:27, 31 October 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4hbx.jpg\|left\|200px]]

-	~~The entry~~ 4hbx ~~is ON HOLD~~	+	{{STRUCTURE_4hbx\| PDB=4hbx \| SCENE= }}

-	Authors: Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)	+	===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand===

-	~~Description: Crystal~~ Structure ~~of the first bromodomain of human BRD4 in complex with~~ a ~~quinazolin ligand~~	+
		+	==About this Structure==
		+	[[4hbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBX OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Bunnage, M E.]]
		+	[[Category: Cook, A S.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A.]]
		+	[[Category: Felletar, I.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Fish, P V.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Owen, D R.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: Qi, J.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Bromodomain]]
		+	[[Category: Cap]]
		+	[[Category: Cell cycle]]
		+	[[Category: Hunk1]]
		+	[[Category: Mcap]]
		+	[[Category: Mitotic chromosome associated protein]]
		+	[[Category: Protein binding-inhibitor complex]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomics consortium]]

OCA: Protected "4hbx" [edit=sysop:move=sysop]

OCA — Wed, 10 Oct 2012 06:58:59 GMT

Protected "4hbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 10 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hbx is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V...

OCA — Wed, 10 Oct 2012 06:58:57 GMT

New page: '''Unreleased structure''' The entry 4hbx is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V...

New page

'''Unreleased structure'''

The entry 4hbx is ON HOLD

Authors: Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand