4hfb - Revision history

OCA at 11:40, 1 March 2024

OCA — Fri, 01 Mar 2024 11:40:24 GMT

←Older revision		Revision as of 11:40, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HFB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [https://pdbe.org/4hfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [https://www.ebi.ac.uk/pdbsum/4hfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [https://pdbe.org/4hfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [https://www.ebi.ac.uk/pdbsum/4hfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>		[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ethanol alters nerve signalling by interacting with proteins in the central nervous system, particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments on Gloeobacter violaceus ligand-gated ion channel, a prokaryotic member of this family, identified a single-site variant that is potentiated by pharmacologically relevant concentrations of ethanol. Here we determine crystal structures of the ethanol-sensitized variant in the absence and presence of ethanol and related modulators, which bind in a transmembrane cavity between channel subunits and may stabilize the open form of the channel. Structural and mutagenesis studies defined overlapping mechanisms of potentiation by alcohols and anaesthetics via the inter-subunit cavity. Furthermore, homology modelling show this cavity to be conserved in human ethanol-sensitive glycine and GABA(A) receptors, and to involve residues previously shown to influence alcohol and anaesthetic action on these proteins. These results suggest a common structural basis for ethanol potentiation of an important class of targets for neurological actions of ethanol.
-
-	Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.,Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682. PMID:23591864<ref>PMID:23591864</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hfb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:13, 3 November 2022

OCA — Thu, 03 Nov 2022 08:13:39 GMT

←Older revision		Revision as of 08:13, 3 November 2022
Line 1:		Line 1:

	==The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)==		==The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)==
-	<StructureSection load='4hfb' size='340' side='right' caption='[[4hfb]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='4hfb' size='340' side='right'caption='[[4hfb]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Glovi Glovi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HFB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HFB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hfc\|4hfc]], [[4hfd\|4hfd]], [[4hfe\|4hfe]], [[4hfh\|4hfh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [https://pdbe.org/4hfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [https://www.ebi.ac.uk/pdbsum/4hfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfb ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [~~http~~://pdbe.org/4hfb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hfb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glovi~~]]	+	[[Category: Gloeobacter violaceus PCC 7421]]
-	[[Category: Corringer~~, P J~~]]	+	[[Category: Large Structures]]
-	[[Category: Delarue, M]]	+	[[Category: Corringer PJ]]
-	[[Category: Harris~~, R A~~]]	+	[[Category: Delarue M]]
-	[[Category: Howard~~, R J~~]]	+	[[Category: Harris RA]]
-	[[Category: Lee~~, U S~~]]	+	[[Category: Howard RJ]]
-	[[Category: Malherbe, L]]	+	[[Category: Lee US]]
-	[[Category: Sauguet, L]]	+	[[Category: Malherbe L]]
-	~~[[Category: Ion-channel]]~~	+	[[Category: Sauguet L]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pentameric transmembrane channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:38, 5 August 2016

OCA — Fri, 05 Aug 2016 11:38:03 GMT

←Older revision		Revision as of 11:38, 5 August 2016
Line 1:		Line 1:
		+
	==The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)==		==The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)==
	<StructureSection load='4hfb' size='340' side='right' caption='[[4hfb]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='4hfb' size='340' side='right' caption='[[4hfb]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HFB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hfc\|4hfc]], [[4hfd\|4hfd]], [[4hfe\|4hfe]], [[4hfh\|4hfh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hfc\|4hfc]], [[4hfd\|4hfd]], [[4hfe\|4hfe]], [[4hfh\|4hfh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 ~~Gloeobacter violaceus PCC 7421~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [http://www.ebi.ac.uk/pdbsum/4hfb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [http://pdbe.org/4hfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [http://www.ebi.ac.uk/pdbsum/4hfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hfb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hfb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gloeobacter violaceus pcc 7421~~]]	+	[[Category: Glovi]]
	[[Category: Corringer, P J]]		[[Category: Corringer, P J]]
	[[Category: Delarue, M]]		[[Category: Delarue, M]]

OCA at 02:05, 25 December 2014

OCA — Thu, 25 Dec 2014 02:05:50 GMT

←Older revision		Revision as of 02:05, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hfb\| PDB=4hfb \| SCENE= }}~~	+	==The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)==
-	===The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)===	+	<StructureSection load='4hfb' size='340' side='right' caption='[[4hfb]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23591864}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hfb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HFB FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hfc\|4hfc]], [[4hfd\|4hfd]], [[4hfe\|4hfe]], [[4hfh\|4hfh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 Gloeobacter violaceus PCC 7421])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hfb RCSB], [http://www.ebi.ac.uk/pdbsum/4hfb PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>		[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ethanol alters nerve signalling by interacting with proteins in the central nervous system, particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments on Gloeobacter violaceus ligand-gated ion channel, a prokaryotic member of this family, identified a single-site variant that is potentiated by pharmacologically relevant concentrations of ethanol. Here we determine crystal structures of the ethanol-sensitized variant in the absence and presence of ethanol and related modulators, which bind in a transmembrane cavity between channel subunits and may stabilize the open form of the channel. Structural and mutagenesis studies defined overlapping mechanisms of potentiation by alcohols and anaesthetics via the inter-subunit cavity. Furthermore, homology modelling show this cavity to be conserved in human ethanol-sensitive glycine and GABA(A) receptors, and to involve residues previously shown to influence alcohol and anaesthetic action on these proteins. These results suggest a common structural basis for ethanol potentiation of an important class of targets for neurological actions of ethanol.

-	~~==About this Structure==~~	+	Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.,Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682. PMID:23591864<ref>PMID:23591864</ref>
-	~~[[4hfb]] is~~ a ~~5 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023591864</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gloeobacter violaceus pcc 7421]]		[[Category: Gloeobacter violaceus pcc 7421]]
-	[[Category: Corringer, P J.]]	+	[[Category: Corringer, P J]]
-	[[Category: Delarue, M.]]	+	[[Category: Delarue, M]]
-	[[Category: Harris, R A.]]	+	[[Category: Harris, R A]]
-	[[Category: Howard, R J.]]	+	[[Category: Howard, R J]]
-	[[Category: Lee, U S.]]	+	[[Category: Lee, U S]]
-	[[Category: Malherbe, L.]]	+	[[Category: Malherbe, L]]
-	[[Category: Sauguet, L.]]	+	[[Category: Sauguet, L]]
	[[Category: Ion-channel]]		[[Category: Ion-channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Pentameric transmembrane channel]]		[[Category: Pentameric transmembrane channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 12:30, 3 July 2013

OCA — Wed, 03 Jul 2013 12:30:45 GMT

←Older revision		Revision as of 12:30, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4hfb\| PDB=4hfb \| SCENE= }}		{{STRUCTURE_4hfb\| PDB=4hfb \| SCENE= }}
	===The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)===		===The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)===
		+	{{ABSTRACT_PUBMED_23591864}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023591864</ref><references group="xtra"/><references/>
	[[Category: Gloeobacter violaceus pcc 7421]]		[[Category: Gloeobacter violaceus pcc 7421]]
	[[Category: Corringer, P J.]]		[[Category: Corringer, P J.]]

OCA at 20:33, 17 April 2013

OCA — Wed, 17 Apr 2013 20:33:21 GMT

←Older revision		Revision as of 20:33, 17 April 2013
Line 1:		Line 1:
-	'~~''Unreleased structure'''~~	+	{{STRUCTURE_4hfb\| PDB=4hfb \| SCENE= }}
		+	===The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)===

-	~~The entry 4hfb~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>

-	~~Authors~~: ~~Sauguet, L~~.~~, Howard, R~~.J.~~, Malherbe, L., Lee, U.S., Corringer, P.J~~.~~, Harris, R~~.A.~~, Delarue, M~~.	+	==About this Structure==
		+	[[4hfb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFB OCA].

-	~~Description~~: ~~The GLIC pentameric Ligand-Gated Ion Channel F14'~~A ~~ethanol~~-~~sensitive mutant (Apo)~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Gloeobacter violaceus pcc 7421]]
		+	[[Category: Corringer, P J.]]
		+	[[Category: Delarue, M.]]
		+	[[Category: Harris, R A.]]
		+	[[Category: Howard, R J.]]
		+	[[Category: Lee, U S.]]
		+	[[Category: Malherbe, L.]]
		+	[[Category: Sauguet, L.]]
		+	[[Category: Ion-channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pentameric transmembrane channel]]
		+	[[Category: Transport protein]]

OCA at 08:38, 31 October 2012

OCA — Wed, 31 Oct 2012 08:38:18 GMT

←Older revision		Revision as of 08:38, 31 October 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hfb is ON HOLD	+	The entry 4hfb is ON HOLD until Paper Publication

	Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M.		Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M.

	Description: The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)		Description: The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)

OCA: Protected "4hfb" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2012 06:35:48 GMT

Protected "4hfb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 17 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hfb is ON HOLD Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M. Description: The GLIC penta...

OCA — Wed, 17 Oct 2012 06:35:47 GMT

New page: '''Unreleased structure''' The entry 4hfb is ON HOLD Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M. Description: The GLIC penta...

New page

'''Unreleased structure'''

The entry 4hfb is ON HOLD

Authors: Sauguet, L., Howard, R.J., Malherbe, L., Lee, U.S., Corringer, P.J., Harris, R.A., Delarue, M.

Description: The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)