4hgc - Revision history

OCA at 15:05, 20 September 2023

OCA — Wed, 20 Sep 2023 15:05:08 GMT

←Older revision		Revision as of 15:05, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NLY:N-(4-AMINOBUTYL)GLYCINE'>NLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NLY:N-(4-AMINOBUTYL)GLYCINE'>NLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [https://pdbe.org/4hgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [https://www.ebi.ac.uk/pdbsum/4hgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [https://pdbe.org/4hgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [https://www.ebi.ac.uk/pdbsum/4hgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:14, 3 November 2022

OCA — Thu, 03 Nov 2022 08:14:46 GMT

←Older revision		Revision as of 08:14, 3 November 2022
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	<StructureSection load='4hgc' size='340' side='right'caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4hgc' size='340' side='right'caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NLY:N-(4-AMINOBUTYL)GLYCINE'>NLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NLY:N-(4-AMINOBUTYL)GLYCINE'>NLY</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [https://pdbe.org/4hgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [https://www.ebi.ac.uk/pdbsum/4hgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgc ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mi4\|3mi4]]~~, ~~[[1sfi\|1sfi]], [[3p8f\|3p8f]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [~~http~~://pdbe.org/4hgc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hgc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SFTI1_HELAN SFTI1_HELAN~~]~~] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>~~	+	[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Trypsin\|Trypsin]]	+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]	+	*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Helianthus annuus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Trypsin]]~~	+	[[Category: Jaskolski M]]
-	[[Category: Jaskolski, M]]	+	[[Category: Krzywda S]]
-	[[Category: Krzywda, S]]	+	[[Category: Rolka K]]
-	[[Category: Rolka, K]]	+	[[Category: Stawikowski M]]
-	[[Category: Stawikowski, M]]	+
-	~~[[Category: Cyclic peptide]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Peptoid]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 09:24, 5 February 2020

OCA — Wed, 05 Feb 2020 09:24:13 GMT

←Older revision		Revision as of 09:24, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1==		==Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1==
-	<StructureSection load='4hgc' size='340' side='right' caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>	+	<StructureSection load='4hgc' size='340' side='right'caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGC FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4hgc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hgc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin\|Trypsin]]
		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Jaskolski, M]]		[[Category: Jaskolski, M]]

OCA at 08:39, 15 November 2017

OCA — Wed, 15 Nov 2017 08:39:54 GMT

←Older revision		Revision as of 08:39, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4hgc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hgc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Trypsin\|Trypsin]]
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:02, 5 August 2016

OCA — Fri, 05 Aug 2016 04:02:45 GMT

←Older revision		Revision as of 04:02, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1==		==Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1==
	<StructureSection load='4hgc' size='340' side='right' caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4hgc' size='340' side='right' caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mi4\|3mi4]], [[1sfi\|1sfi]], [[3p8f\|3p8f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mi4\|3mi4]], [[1sfi\|1sfi]], [[3p8f\|3p8f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [http://www.ebi.ac.uk/pdbsum/4hgc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [http://pdbe.org/4hgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [http://www.ebi.ac.uk/pdbsum/4hgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hgc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:40, 25 December 2014

OCA — Thu, 25 Dec 2014 15:40:54 GMT

←Older revision		Revision as of 15:40, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hgc\| PDB=4hgc \| SCENE= }}~~	+	==Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1==
-	===Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1===	+	<StructureSection load='4hgc' size='340' side='right' caption='[[4hgc]], [[Resolution\|resolution]] 1.29Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24598736}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGC FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NLY:N-(4-AMINOBUTYL)GLYCINE'>NLY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mi4\|3mi4]], [[1sfi\|1sfi]], [[3p8f\|3p8f]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgc RCSB], [http://www.ebi.ac.uk/pdbsum/4hgc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>		[[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptide-peptoid hybrids are found to be potent inhibitors of serine proteases. These engineered peptidomimetics benefit from both types of units of the biopolymeric structure: the natural inhibitor part serves as a good binding template, while the P1-positioned peptoid component provides complete resistance towards proteolysis. In this report, the mechanism of proteolytic resistance of a P1 peptoid-containing analogue is postulated based on the crystal structure of the (NLys)(5)-modified sunflower trypsin inhibitor SFTI-1 in complex with bovine trypsin solved at 1.29 A resolution. The structural differences between the (NLys)(5)SFTI-1-trypsin complex and the native SFTI-1-trypsin complex are surprisingly small and reveal the key role of the carbonyl group of the Ser214 residue of the enzyme, which is crucial for binding of the inhibitor and plays a crucial role in proteolysis mediated by serine proteases. The incorporated NLys5 peptoid residue prevents Ser214 from forming a hydrogen bond to the P1 residue, and in turn Gln192 does not form a hydrogen bond to the carbonyl group of the P2 residue. It also increases the distance between the Ser214 carbonyl group and the Ser195 residue, thus preventing proteolysis. The hybrid inhibitor structure reported here provides insight into protein-protein interaction, which can be efficiently and selectively probed with the use of peptoids incorporated within endogenous peptide ligands.
		+
		+	Structure of a proteolytically resistant analogue of (NLys)(5)SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis.,Krzywda S, Jaskolski M, Rolka K, Stawikowski MJ Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):668-75. doi:, 10.1107/S1399004713032252. Epub 2014 Feb 15. PMID:24598736<ref>PMID:24598736</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hgc]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024598736</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Trypsin\|Trypsin]]
		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
-	[[Category: Jaskolski, M.]]	+	[[Category: Jaskolski, M]]
-	[[Category: Krzywda, S.]]	+	[[Category: Krzywda, S]]
-	[[Category: Rolka, K.]]	+	[[Category: Rolka, K]]
-	[[Category: Stawikowski, M.]]	+	[[Category: Stawikowski, M]]
	[[Category: Cyclic peptide]]		[[Category: Cyclic peptide]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 06:35, 26 March 2014

OCA — Wed, 26 Mar 2014 06:35:05 GMT

←Older revision		Revision as of 06:35, 26 March 2014
Line 1:		Line 1:
	{{STRUCTURE_4hgc\| PDB=4hgc \| SCENE= }}		{{STRUCTURE_4hgc\| PDB=4hgc \| SCENE= }}
	===Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1===		===Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1===
		+	{{ABSTRACT_PUBMED_24598736}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024598736</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Trypsin]]		[[Category: Trypsin]]

OCA at 06:37, 10 October 2013

OCA — Thu, 10 Oct 2013 06:37:47 GMT

←Older revision		Revision as of 06:37, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hgc\| PDB=4hgc \| SCENE= }}
		+	===Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1===

-	~~The entry 4hgc is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>

-	~~Authors~~: ~~Krzywda, S~~.~~, Jaskolski, M~~.~~, Rolka, K~~.~~, Stawikowski, M~~.	+	==About this Structure==
		+	[[4hgc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGC OCA].

-	~~Description~~: ~~Crystal structure of bovine trypsin complexed with sfti~~-~~1 analog containing a peptoid residue at position p1~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Bos taurus]]
		+	[[Category: Trypsin]]
		+	[[Category: Jaskolski, M.]]
		+	[[Category: Krzywda, S.]]
		+	[[Category: Rolka, K.]]
		+	[[Category: Stawikowski, M.]]
		+	[[Category: Cyclic peptide]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Peptoid]]
		+	[[Category: Serine protease]]

OCA at 08:38, 31 October 2012

OCA — Wed, 31 Oct 2012 08:38:57 GMT

←Older revision		Revision as of 08:38, 31 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hgc is ON HOLD	+	The entry 4hgc is ON HOLD until Paper Publication

	Authors: Krzywda, S., Jaskolski, M., Rolka, K., Stawikowski, M.		Authors: Krzywda, S., Jaskolski, M., Rolka, K., Stawikowski, M.

-	Description: Crystal structure of ~~the~~ bovine trypsin complexed with ~~SFTI~~-1 analog containing peptoid residue at P1 position	+	Description: Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1

OCA: Protected "4hgc" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2012 06:36:44 GMT

Protected "4hgc" [edit=sysop:move=sysop]

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Revision as of 06:36, 17 October 2012