4hgg - Revision history

OCA at 15:05, 20 September 2023

OCA — Wed, 20 Sep 2023 15:05:12 GMT

←Older revision		Revision as of 15:05, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [https://pdbe.org/4hgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [https://www.ebi.ac.uk/pdbsum/4hgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [https://pdbe.org/4hgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [https://www.ebi.ac.uk/pdbsum/4hgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:14, 3 November 2022

OCA — Thu, 03 Nov 2022 08:14:58 GMT

←Older revision		Revision as of 08:14, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene==		==Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene==
-	<StructureSection load='4hgg' size='340' side='right' caption='[[4hgg]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4hgg' size='340' side='right'caption='[[4hgg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_14581 Atcc 14581~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1jpz\|1jpz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [https://pdbe.org/4hgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [https://www.ebi.ac.uk/pdbsum/4hgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgg ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cyp102, cyp102A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 ATCC 14581])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [~~http~~://pdbe.org/4hgg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hgg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CPXB_BACME CPXB_BACME]~~] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of ~~medium and long-chain~~ fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). ~~The~~ reductase domain ~~is required for~~ electron transfer from ~~NADP~~ to cytochrome P450.	+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hgg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hgg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 14581~~]]	+	[[Category: Large Structures]]
-	[[Category: Bocola, M]]	+	[[Category: Priestia megaterium]]
-	[[Category: Mueller-Dieckmann, J]]	+	[[Category: Bocola M]]
-	[[Category: Panneerselvam, S]]	+	[[Category: Mueller-Dieckmann J]]
-	[[Category: Schwaneberg, U]]	+	[[Category: Panneerselvam S]]
-	[[Category: Shehzad, A]]	+	[[Category: Schwaneberg U]]
-	[[Category: Wilmanns, M]]	+	[[Category: Shehzad A]]
-	~~[[Category: Heme binding]]~~	+	[[Category: Wilmanns M]]
-	~~[[Category: Hemoprotein]]~~	+
-	~~[[Category: Inverted enantioselectivity]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: P450 bm3]]~~	+
-	~~[[Category: Styrene epoxidation~~]]	+

OCA at 08:40, 15 November 2017

OCA — Wed, 15 Nov 2017 08:40:30 GMT

←Older revision		Revision as of 08:40, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4hgg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hgg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:48, 4 August 2016

OCA — Thu, 04 Aug 2016 18:48:57 GMT

←Older revision		Revision as of 18:48, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene==		==Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene==
	<StructureSection load='4hgg' size='340' side='right' caption='[[4hgg]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4hgg' size='340' side='right' caption='[[4hgg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_megaterium Bacillus megaterium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14581 Atcc 14581]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1jpz\|1jpz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1jpz\|1jpz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cyp102, cyp102A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 ~~Bacillus megaterium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cyp102, cyp102A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 ATCC 14581])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [http://www.ebi.ac.uk/pdbsum/4hgg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [http://pdbe.org/4hgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [http://www.ebi.ac.uk/pdbsum/4hgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hgg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus megaterium~~]]	+	[[Category: Atcc 14581]]
	[[Category: Bocola, M]]		[[Category: Bocola, M]]
	[[Category: Mueller-Dieckmann, J]]		[[Category: Mueller-Dieckmann, J]]

OCA at 18:22, 24 December 2014

OCA — Wed, 24 Dec 2014 18:22:50 GMT

←Older revision		Revision as of 18:22, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [http://www.ebi.ac.uk/pdbsum/4hgg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [http://www.ebi.ac.uk/pdbsum/4hgg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:02, 21 December 2014

OCA — Sun, 21 Dec 2014 13:02:05 GMT

←Older revision		Revision as of 13:02, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hgg\| PDB=4hgg \| SCENE= }}~~	+	==Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene==
-	===Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene===	+	<StructureSection load='4hgg' size='340' side='right' caption='[[4hgg]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23589805}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hgg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SYN:ETHENYLBENZENE'>SYN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bu7\|1bu7]], [[1jpz\|1jpz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cyp102, cyp102A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 Bacillus megaterium])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgg RCSB], [http://www.ebi.ac.uk/pdbsum/4hgg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Solved crystal structures of P450 BM3 variants in complex with styrene provide on the molecular level a first explanation of how a positively charged surface residue inverts the enantiopreference of styrene epoxidation. The obtained insights into productive and non-productive styrene binding modes deepened our understanding of enantioselective epoxidation with P450 BM3.

-	~~==Function==~~	+	P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation.,Shehzad A, Panneerselvam S, Linow M, Bocola M, Roccatano D, Mueller-Dieckmann J, Wilmanns M, Schwaneberg U Chem Commun (Camb). 2013 May 21;49(41):4694-6. doi: 10.1039/c3cc39076d. Epub 2013, Apr 15. PMID:23589805<ref>PMID:23589805</ref>
-	~~[[http:/~~/~~www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation~~ of ~~medium and long-chain fatty acids at omega-1~~, ~~omega-2 and omega-3 positions~~, ~~with optimum chain lengths of 12~~-~~16 carbons (lauric~~, ~~myristic~~, ~~and palmitic acids~~). ~~The reductase domain is required for electron transfer from NADP to cytochrome P450~~.	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[~~4hgg~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA].~~	+	</div>
		+
		+	==See Also==
		+	*[[Cytochrome P450\|Cytochrome P450]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus megaterium]]		[[Category: Bacillus megaterium]]
-	[[Category: Bocola, M.]]	+	[[Category: Bocola, M]]
-	[[Category: Mueller-Dieckmann, J.]]	+	[[Category: Mueller-Dieckmann, J]]
-	[[Category: Panneerselvam, S.]]	+	[[Category: Panneerselvam, S]]
-	[[Category: Schwaneberg, U.]]	+	[[Category: Schwaneberg, U]]
-	[[Category: Shehzad, A.]]	+	[[Category: Shehzad, A]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Heme binding]]		[[Category: Heme binding]]
	[[Category: Hemoprotein]]		[[Category: Hemoprotein]]

OCA at 07:35, 2 May 2013

OCA — Thu, 02 May 2013 07:35:26 GMT

←Older revision		Revision as of 07:35, 2 May 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hgg\| PDB=4hgg \| SCENE= }}
		+	===Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene===
		+	{{ABSTRACT_PUBMED_23589805}}

-	The ~~entry 4hgg~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.

-	~~Authors~~: ~~Shehzad, A~~.~~, Panneerselvam, S~~., Bocola, M., Mueller-Dieckmann, J., ~~Wilmanns, M~~., Schwaneberg, U.	+	==About this Structure==
-		+	[[4hgg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGG OCA].
-	~~Description~~: ~~Crystal structure of~~ P450 ~~BM3 5F5R heme domain variant complexed with styrene~~	+	[[Category: Bacillus megaterium]]
		+	[[Category: Bocola, M.]]
		+	[[Category: Mueller-Dieckmann, J.]]
		+	[[Category: Panneerselvam, S.]]
		+	[[Category: Schwaneberg, U.]]
		+	[[Category: Shehzad, A.]]
		+	[[Category: Wilmanns, M.]]
		+	[[Category: Heme binding]]
		+	[[Category: Hemoprotein]]
		+	[[Category: Inverted enantioselectivity]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: P450 bm3]]
		+	[[Category: Styrene epoxidation]]

OCA at 14:02, 28 November 2012

OCA — Wed, 28 Nov 2012 14:02:02 GMT

←Older revision		Revision as of 14:02, 28 November 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hgg is ON HOLD	+	The entry 4hgg is ON HOLD until Paper Publication

	Authors: Shehzad, A., Panneerselvam, S., Bocola, M., Mueller-Dieckmann, J., Wilmanns, M., Schwaneberg, U.		Authors: Shehzad, A., Panneerselvam, S., Bocola, M., Mueller-Dieckmann, J., Wilmanns, M., Schwaneberg, U.

	Description: Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene		Description: Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene

OCA: Protected "4hgg" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2012 06:36:51 GMT

Protected "4hgg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 17 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hgg is ON HOLD Authors: Shehzad, A., Panneerselvam, S., Bocola, M., Mueller-Dieckmann, J., Wilmanns, M., Schwaneberg, U. Description: Crystal stru...

OCA — Wed, 17 Oct 2012 06:36:50 GMT

New page: '''Unreleased structure''' The entry 4hgg is ON HOLD Authors: Shehzad, A., Panneerselvam, S., Bocola, M., Mueller-Dieckmann, J., Wilmanns, M., Schwaneberg, U. Description: Crystal stru...

New page

'''Unreleased structure'''

The entry 4hgg is ON HOLD

Authors: Shehzad, A., Panneerselvam, S., Bocola, M., Mueller-Dieckmann, J., Wilmanns, M., Schwaneberg, U.

Description: Crystal structure of P450 BM3 5F5R heme domain variant complexed with styrene