4hgw - Revision history

OCA at 15:05, 20 September 2023

OCA — Wed, 20 Sep 2023 15:05:34 GMT

←Older revision		Revision as of 15:05, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [https://pdbe.org/4hgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [https://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [https://pdbe.org/4hgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [https://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:15, 3 November 2022

OCA — Thu, 03 Nov 2022 08:15:55 GMT

←Older revision		Revision as of 08:15, 3 November 2022
Line 3:		Line 3:
	<StructureSection load='4hgw' size='340' side='right'caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4hgw' size='340' side='right'caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4HGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [~~http~~://pdbe.org/4hgw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [https://pdbe.org/4hgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [https://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Brooks~~, C L~~]]	+	[[Category: Brooks CL]]
-	[[Category: Evans~~, S V]]~~	+	[[Category: Evans SV]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lp~~]]	+

OCA at 05:52, 22 April 2020

OCA — Wed, 22 Apr 2020 05:52:51 GMT

←Older revision		Revision as of 05:52, 22 April 2020
Line 3:		Line 3:
	<StructureSection load='4hgw' size='340' side='right'caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4hgw' size='340' side='right'caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://pdbe.org/4hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://pdbe.org/4hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:39, 27 March 2019

OCA — Wed, 27 Mar 2019 07:39:38 GMT

←Older revision		Revision as of 07:39, 27 March 2019
Line 1:		Line 1:

	==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==		==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==
-	<StructureSection load='4hgw' size='340' side='right' caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4hgw' size='340' side='right'caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>,~~ <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://pdbe.org/4hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://pdbe.org/4hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Brooks, C L]]		[[Category: Brooks, C L]]

OCA at 20:02, 15 December 2016

OCA — Thu, 15 Dec 2016 20:02:21 GMT

←Older revision		Revision as of 20:02, 15 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==		==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==
	<StructureSection load='4hgw' size='340' side='right' caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4hgw' size='340' side='right' caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://pdbe.org/4hgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hgw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hgw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Brooks, C L]]		[[Category: Brooks, C L]]
	[[Category: Evans, S V]]		[[Category: Evans, S V]]

OCA at 09:40, 10 December 2014

OCA — Wed, 10 Dec 2014 09:40:25 GMT

←Older revision		Revision as of 09:40, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hgw.~~png~~\|~~left\|200px~~]]	+	==Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide==
		+	<StructureSection load='4hgw' size='340' side='right' caption='[[4hgw]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HGW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=KTU:PROP-2-EN-1-YL+3,5-DIDEOXY-ALPHA-D-THREO-OCT-5-EN-2-ULOPYRANOSIDONIC+ACID'>KTU</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hgw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hgw RCSB], [http://www.ebi.ac.uk/pdbsum/4hgw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The near-germline antibody S25-2 exhibits a remarkable cross-reactivity for oligosaccharides containing the bacterial lipopolysaccharide carbohydrate 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo). The recent synthesis of a variety of Kdo analogues permits a detailed structural analysis of the importance of specific interactions in antigen recognition by S25-2. The Kdo disaccharide analogue Kdo-(2-->4)-5,6-dehydro-Kdo lacks a 5-OH group on the second Kdo residue and has been cocrystallized with S25-2. The structure reveals that the modification of the Kdo residue at position 5 results in a rearrangement of intramolecular hydrogen bonds in the antigen that allows it to assume a novel conformation in the antibody-combining site. The cross-reactive binding of S25-2 to this synthetic ligand highlights the adaptability of this antibody to non-natural synthetic analogues.

-	~~{{STRUCTURE_4hgw\| PDB=4hgw \| SCENE= }}~~	+	Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide.,Brooks CL, Wimmer K, Kosma P, Muller-Loennies S, Brade L, Brade H, Evans SV Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):2-5. doi:, 10.1107/S1744309112047422. Epub 2012 Dec 25. PMID:23295476<ref>PMID:23295476</ref>

-	~~===Crystal structure of S25-2 in complex with a 5~~,~~6-dehydro-Kdo disaccharide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23295476}}~~	+	==See Also==
-		+	*[[Antibody\|Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4hgw~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Brooks, C L.]]	+	[[Category: Brooks, C L]]
-	[[Category: Evans, S V.]]	+	[[Category: Evans, S V]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Lp]]		[[Category: Lp]]

OCA at 12:26, 30 January 2013

OCA — Wed, 30 Jan 2013 12:26:09 GMT

←Older revision		Revision as of 12:26, 30 January 2013
Line 1:		Line 1:
-	[[Image:4hgw.~~jpg~~\|left\|200px]]	+	[[Image:4hgw.png\|left\|200px]]

	{{STRUCTURE_4hgw\| PDB=4hgw \| SCENE= }}		{{STRUCTURE_4hgw\| PDB=4hgw \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide===		===Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide===

		+	{{ABSTRACT_PUBMED_23295476}}

	==About this Structure==		==About this Structure==

OCA at 08:24, 9 January 2013

OCA — Wed, 09 Jan 2013 08:24:49 GMT

←Older revision		Revision as of 08:24, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hgw.jpg\|left\|200px]]

-	~~The entry~~ 4hgw ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hgw\| PDB=4hgw \| SCENE= }}

-	~~Authors: Brooks~~, ~~C.L., Evans, S.V.~~	+	===Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide===

-	~~Description: Crystal structure of S25-~~2 ~~in complex~~ with ~~a 5,6~~-~~dehydro-Kdo disaccharide~~	+
		+	==About this Structure==
		+	[[4hgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HGW OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Brooks, C L.]]
		+	[[Category: Evans, S V.]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Lp]]

OCA at 07:10, 24 October 2012

OCA — Wed, 24 Oct 2012 07:10:37 GMT

←Older revision		Revision as of 07:10, 24 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hgw is ON HOLD	+	The entry 4hgw is ON HOLD until Paper Publication

	Authors: Brooks, C.L., Evans, S.V.		Authors: Brooks, C.L., Evans, S.V.

	Description: Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide		Description: Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide

OCA: Protected "4hgw" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2012 06:37:20 GMT

Protected "4hgw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:37, 17 October 2012