4hhz - Revision history

OCA at 15:06, 20 September 2023

OCA — Wed, 20 Sep 2023 15:06:09 GMT

←Older revision		Revision as of 15:06, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7199Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [https://pdbe.org/4hhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [https://www.ebi.ac.uk/pdbsum/4hhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [https://pdbe.org/4hhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [https://www.ebi.ac.uk/pdbsum/4hhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:18, 3 November 2022

OCA — Thu, 03 Nov 2022 08:18:16 GMT

←Older revision		Revision as of 08:18, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of PARP catalytic domain in complex with novel inhibitors==		==Crystal structure of PARP catalytic domain in complex with novel inhibitors==
-	<StructureSection load='4hhz' size='340' side='right' caption='[[4hhz]], [[Resolution\|resolution]] 2.72Å' scene=''>	+	<StructureSection load='4hhz' size='340' side='right'caption='[[4hhz]], [[Resolution\|resolution]] 2.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT, PARP1, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [https://pdbe.org/4hhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [https://www.ebi.ac.uk/pdbsum/4hhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhz ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [~~http~~://pdbe.org/4hhz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hhz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>	+	[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Chen, T T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Liu, Q F~~]]	+	[[Category: Chen TT]]
-	[[Category: ~~Xu, Y C~~]]	+	[[Category: Liu QF]]
-	[[Category: ~~Polymerase]]~~	+	[[Category: Xu YC]]
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 20:30, 4 August 2016

OCA — Thu, 04 Aug 2016 20:30:25 GMT

←Older revision		Revision as of 20:30, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PARP catalytic domain in complex with novel inhibitors==		==Crystal structure of PARP catalytic domain in complex with novel inhibitors==
	<StructureSection load='4hhz' size='340' side='right' caption='[[4hhz]], [[Resolution\|resolution]] 2.72Å' scene=''>		<StructureSection load='4hhz' size='340' side='right' caption='[[4hhz]], [[Resolution\|resolution]] 2.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT, PARP1, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT, PARP1, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [http://www.ebi.ac.uk/pdbsum/4hhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [http://pdbe.org/4hhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [http://www.ebi.ac.uk/pdbsum/4hhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hhz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, T T]]		[[Category: Chen, T T]]
	[[Category: Liu, Q F]]		[[Category: Liu, Q F]]

OCA at 19:20, 24 December 2014

OCA — Wed, 24 Dec 2014 19:20:43 GMT

←Older revision		Revision as of 19:20, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hhz\| PDB=4hhz \| SCENE= }}~~	+	==Crystal structure of PARP catalytic domain in complex with novel inhibitors==
-	===Crystal structure of PARP catalytic domain in complex with novel inhibitors===	+	<StructureSection load='4hhz' size='340' side='right' caption='[[4hhz]], [[Resolution\|resolution]] 2.72Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23473053}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hhz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HHZ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15S:N-{(2S)-1-[4-(4-FLUOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1-OXOPROPAN-2-YL}-2-[(9AR)-7-OXO-2,3,7,8,9,9A-HEXAHYDRO-1H-BENZO[DE][1,7]NAPHTHYRIDIN-1-YL]ACETAMIDE'>15S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT, PARP1, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hhz RCSB], [http://www.ebi.ac.uk/pdbsum/4hhz PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>		[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of benzo[de][1,7]naphthyridin-7(8H)-ones possessing a functionalized long-chain appendage have been designed and evaluated as novel PARP1 inhibitors. The initial effort led to the first-generation PARP1 inhibitor 26 bearing a terminal phthalazin-1(2H)-one framework and showing remarkably high PARP1 inhibitory activity (0.31 nM) but only moderate potency in the cell. Further effort generated the second-generation lead 41, showing high potency against both the PARP1 enzyme and BRCA-deficient cells, especially for the BRCA1-deficient MDA-MB-436 cells (CC50 < 0.26 nM). Mechanistic studies revealed that the new PARP1 inhibitors significantly inhibited H2O2-triggered PARylation in SKOV3 cells, induced cellular accumulation of DNA double-strand breaks, and impaired cell-cycle progression in BRCA2-deficient cells. Significant potentiation on the cytotoxicity of Temozolomide was also observed. The unique structural character and exceptionally high potency of 41 made it stand out as a promising drug candidate worthy for further evaluation.
		+
		+	Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors.,Ye N, Chen CH, Chen T, Song Z, He JX, Huan XJ, Song SS, Liu Q, Chen Y, Ding J, Xu Y, Miao ZH, Zhang A J Med Chem. 2013 Mar 21. PMID:23473053<ref>PMID:23473053</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hhz]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, T T.]]	+	[[Category: Chen, T T]]
-	[[Category: Liu, Q F.]]	+	[[Category: Liu, Q F]]
-	[[Category: Xu, Y C.]]	+	[[Category: Xu, Y C]]
	[[Category: Polymerase]]		[[Category: Polymerase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:34, 24 April 2013

OCA — Wed, 24 Apr 2013 10:34:05 GMT

←Older revision		Revision as of 10:34, 24 April 2013
Line 4:		Line 4:

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref><ref>PMID:18172500</ref><ref>PMID:19344625</ref><ref>PMID:19661379</ref>	+	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

	==About this Structure==		==About this Structure==

OCA at 08:51, 27 March 2013

OCA — Wed, 27 Mar 2013 08:51:08 GMT

←Older revision		Revision as of 08:51, 27 March 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hhz\| PDB=4hhz \| SCENE= }}
		+	===Crystal structure of PARP catalytic domain in complex with novel inhibitors===
		+	{{ABSTRACT_PUBMED_23473053}}

-	~~The entry 4hhz~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref><ref>PMID:18172500</ref><ref>PMID:19344625</ref><ref>PMID:19661379</ref>

-	~~Authors~~: ~~Liu, Q~~.F.~~, Chen, T~~.T.~~, Xu, Y~~.C.	+	==About this Structure==
		+	[[4hhz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHZ OCA].

-	~~Description~~: ~~Crystal structure of PARP catalytic domain in~~ complex ~~with novel inhibitors~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, T T.]]
		+	[[Category: Liu, Q F.]]
		+	[[Category: Xu, Y C.]]
		+	[[Category: Polymerase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:11, 24 October 2012

OCA — Wed, 24 Oct 2012 07:11:00 GMT

←Older revision		Revision as of 07:11, 24 October 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hhz is ON HOLD	+	The entry 4hhz is ON HOLD until Paper Publication

-	Authors: Liu,Q.F., Chen,T.T., Xu,Y.C.	+	Authors: Liu, Q.F., Chen, T.T., Xu, Y.C.

-	Description: ~~CRYSTAL STRUCTURE OF~~ PARP ~~CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS~~	+	Description: Crystal structure of PARP catalytic domain in complex with novel inhibitors

OCA: Protected "4hhz" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2012 06:38:24 GMT

Protected "4hhz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 17 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hhz is ON HOLD Authors: Liu,Q.F., Chen,T.T., Xu,Y.C. Description: CRYSTAL STRUCTURE OF PARP CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS

OCA — Wed, 17 Oct 2012 06:38:23 GMT

New page: '''Unreleased structure''' The entry 4hhz is ON HOLD Authors: Liu,Q.F., Chen,T.T., Xu,Y.C. Description: CRYSTAL STRUCTURE OF PARP CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS

New page

'''Unreleased structure'''

The entry 4hhz is ON HOLD

Authors: Liu,Q.F., Chen,T.T., Xu,Y.C.

Description: CRYSTAL STRUCTURE OF PARP CATALYTIC DOMAIN IN COMPLEX WITH NOVEL INHIBITORS