4hjc - Revision history

OCA at 08:20, 3 November 2022

OCA — Thu, 03 Nov 2022 08:20:25 GMT

←Older revision		Revision as of 08:20, 3 November 2022
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	<StructureSection load='4hjc' size='340' side='right'caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>		<StructureSection load='4hjc' size='340' side='right'caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rvfv Rvfv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rift_Valley_fever_virus Rift Valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJC FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hj1\|4hj1]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [https://pdbe.org/4hjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [https://www.ebi.ac.uk/pdbsum/4hjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [~~http~~://pdbe.org/4hjc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hjc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjc ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GP_RVFV GP_RVFV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:23319635, PubMed:29097548). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).[UniProtKB:P09613]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> <ref>PMID:29097548</ref> Plays a role for virus dissemination in the mosquito.[UniProtKB:P21401]<ref>PMID:24551252</ref> Plays a role for virus dissemination in mosquitoes.[UniProtKB:P21401]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rvfv~~]]	+	[[Category: Rift Valley fever virus]]
-	[[Category: Dessau, M]]	+	[[Category: Dessau M]]
-	[[Category: Modis, Y]]	+	[[Category: Modis Y]]
-	~~[[Category: Class ii fusion protein]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Viral membrane]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus entry~~]]	+

OCA at 09:36, 5 February 2020

OCA — Wed, 05 Feb 2020 09:36:10 GMT

←Older revision		Revision as of 09:36, 5 February 2020
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	==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)==		==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)==
-	<StructureSection load='4hjc' size='340' side='right' caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>	+	<StructureSection load='4hjc' size='340' side='right'caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rvfv]]		[[Category: Rvfv]]
	[[Category: Dessau, M]]		[[Category: Dessau, M]]

OCA at 16:13, 11 August 2016

OCA — Thu, 11 Aug 2016 16:13:29 GMT

←Older revision		Revision as of 16:13, 11 August 2016
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		+
	==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)==		==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)==
	<StructureSection load='4hjc' size='340' side='right' caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>		<StructureSection load='4hjc' size='340' side='right' caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rift_valley_fever_virus Rift valley fever virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hj1\|4hj1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hj1\|4hj1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [http://www.ebi.ac.uk/pdbsum/4hjc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [http://pdbe.org/4hjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [http://www.ebi.ac.uk/pdbsum/4hjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hjc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rift valley fever virus~~]]	+	[[Category: Rvfv]]
	[[Category: Dessau, M]]		[[Category: Dessau, M]]
	[[Category: Modis, Y]]		[[Category: Modis, Y]]

OCA at 12:46, 4 January 2015

OCA — Sun, 04 Jan 2015 12:46:52 GMT

←Older revision		Revision as of 12:46, 4 January 2015
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-	[[~~Image:~~4hjc.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)==
		+	<StructureSection load='4hjc' size='340' side='right' caption='[[4hjc]], [[Resolution\|resolution]] 4.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rift_valley_fever_virus Rift valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hj1\|4hj1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [http://www.ebi.ac.uk/pdbsum/4hjc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rift Valley fever virus (RVFV), like many other Bunyaviridae family members, is an emerging human and animal pathogen. Bunyaviruses have an outer lipid envelope bearing two glycoproteins, G(N) and G(C), required for cell entry. Bunyaviruses deliver their genome into the host-cell cytoplasm by fusing their envelope with an endosomal membrane. The molecular mechanism of this key entry step is unknown. The crystal structure of RVFV G(C) reveals a class II fusion protein architecture found previously in flaviviruses and alphaviruses. The structure identifies G(C) as the effector of membrane fusion and provides a direct view of the membrane anchor that initiates fusion. A structure of nonglycosylated G(C) reveals an extended conformation that may represent a fusion intermediate. Unanticipated similarities between G(C) and flavivirus envelope proteins reveal an evolutionary link between the two virus families and provide insights into the organization of G(C) in the outer shell of RVFV.

-	~~{{STRUCTURE_4hjc\| PDB=4hjc \| SCENE= }}~~	+	Crystal structure of glycoprotein C from Rift Valley fever virus.,Dessau M, Modis Y Proc Natl Acad Sci U S A. 2013 Jan 14. PMID:23319635<ref>PMID:23319635</ref>

-	~~===Crystal structure~~ of ~~glycoprotein C from Rift Valley Fever Virus (non-glycosylated)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23319635}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hjc]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rift_valley_fever_virus Rift valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA].~~	+	</StructureSection>
	[[Category: Rift valley fever virus]]		[[Category: Rift valley fever virus]]
-	[[Category: Dessau, M.]]	+	[[Category: Dessau, M]]
-	[[Category: Modis, Y.]]	+	[[Category: Modis, Y]]
	[[Category: Class ii fusion protein]]		[[Category: Class ii fusion protein]]
	[[Category: Membrane fusion]]		[[Category: Membrane fusion]]

OCA at 12:29, 30 January 2013

OCA — Wed, 30 Jan 2013 12:29:24 GMT

←Older revision		Revision as of 12:29, 30 January 2013
Line 1:		Line 1:
-	[[Image:4hjc.~~jpg~~\|left\|200px]]	+	[[Image:4hjc.png\|left\|200px]]

	{{STRUCTURE_4hjc\| PDB=4hjc \| SCENE= }}		{{STRUCTURE_4hjc\| PDB=4hjc \| SCENE= }}
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	===Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)===		===Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)===

		+	{{ABSTRACT_PUBMED_23319635}}

	==About this Structure==		==About this Structure==

OCA at 09:12, 16 January 2013

OCA — Wed, 16 Jan 2013 09:12:02 GMT

←Older revision		Revision as of 09:12, 16 January 2013
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-	~~'''Unreleased structure'''~~	+	[[Image:4hjc.jpg\|left\|200px]]

-	~~The entry~~ 4hjc ~~is ON HOLD~~	+	{{STRUCTURE_4hjc\| PDB=4hjc \| SCENE= }}

-	~~Authors: Dessau, M., Modis, Y.~~	+	===Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)===

-	~~Description: Crystal~~ structure ~~of glycoprotein C~~ from Rift ~~Valley Fever Virus (non~~-~~glycosylated)~~	+
		+	==About this Structure==
		+	[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rift_valley_fever_virus Rift valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA].
		+	[[Category: Rift valley fever virus]]
		+	[[Category: Dessau, M.]]
		+	[[Category: Modis, Y.]]
		+	[[Category: Class ii fusion protein]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Viral membrane]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus entry]]

OCA at 08:49, 2 January 2013

OCA — Wed, 02 Jan 2013 08:49:18 GMT

←Older revision		Revision as of 08:49, 2 January 2013
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	The entry 4hjc is ON HOLD		The entry 4hjc is ON HOLD

-	Authors: Dessau, M., Modis, M.	+	Authors: Dessau, M., Modis, Y.

	Description: Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)		Description: Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)

OCA at 10:59, 19 December 2012

OCA — Wed, 19 Dec 2012 10:59:36 GMT

←Older revision		Revision as of 10:59, 19 December 2012
Line 5:		Line 5:
	Authors: Dessau, M., Modis, M.		Authors: Dessau, M., Modis, M.

-	Description: Crystal structure of glycoprotein	+	Description: Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)

OCA at 13:22, 8 November 2012

OCA — Thu, 08 Nov 2012 13:22:37 GMT

←Older revision		Revision as of 13:22, 8 November 2012
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	Authors: Dessau, M., Modis, M.		Authors: Dessau, M., Modis, M.

-	Description: ~~crystal~~ structure of glycoprotein	+	Description: Crystal structure of glycoprotein

OCA: Protected "4hjc" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2012 07:11:50 GMT

Protected "4hjc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:11, 24 October 2012