4hjk - Revision history

OCA at 15:07, 20 September 2023

OCA — Wed, 20 Sep 2023 15:07:17 GMT

←Older revision		Revision as of 15:07, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.784Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [https://pdbe.org/4hjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [https://www.ebi.ac.uk/pdbsum/4hjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [https://pdbe.org/4hjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [https://www.ebi.ac.uk/pdbsum/4hjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:20, 3 November 2022

OCA — Thu, 03 Nov 2022 08:20:51 GMT

←Older revision		Revision as of 08:20, 3 November 2022
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	==U7Ub7 Disulfide variant==		==U7Ub7 Disulfide variant==
-	<StructureSection load='4hjk' size='340' side='right' caption='[[4hjk]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='4hjk' size='340' side='right'caption='[[4hjk]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk2\|4hk2]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [https://pdbe.org/4hjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [https://www.ebi.ac.uk/pdbsum/4hjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjk ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp434K0435, Ubiquitin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [~~http~~://pdbe.org/4hjk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hjk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RL40_HUMAN RL40_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref> Ribosomal protein L40 is a component of the 60S subunit of the ribosome.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>

	==See Also==		==See Also==
-	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]	+	*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Murray, J M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rouge, L~~]]	+	[[Category: Murray JM]]
-	[[Category: ~~Cytoplasmic]]~~	+	[[Category: Rouge L]]
-	~~[[Category: Signaling protein-inhibitor complex]]~~	+
-	~~[[Category: Usp7~~]]	+

OCA at 19:54, 15 December 2016

OCA — Thu, 15 Dec 2016 19:54:17 GMT

←Older revision		Revision as of 19:54, 15 December 2016
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		+
	==U7Ub7 Disulfide variant==		==U7Ub7 Disulfide variant==
	<StructureSection load='4hjk' size='340' side='right' caption='[[4hjk]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4hjk' size='340' side='right' caption='[[4hjk]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk2\|4hk2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk2\|4hk2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp434K0435, Ubiquitin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp434K0435, Ubiquitin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [http://www.ebi.ac.uk/pdbsum/4hjk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [http://pdbe.org/4hjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [http://www.ebi.ac.uk/pdbsum/4hjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjk ProSAT]</span></td></tr>
	</table>		</table>

Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Murray, J M]]		[[Category: Murray, J M]]
	[[Category: Rouge, L]]		[[Category: Rouge, L]]

OCA at 09:21, 10 December 2014

OCA — Wed, 10 Dec 2014 09:21:45 GMT

←Older revision		Revision as of 09:21, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hjk.~~jpg~~\|~~left~~\|~~200px~~]]	+	==U7Ub7 Disulfide variant==
		+	<StructureSection load='4hjk' size='340' side='right' caption='[[4hjk]], [[Resolution\|resolution]] 1.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hk2\|4hk2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp434K0435, Ubiquitin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjk RCSB], [http://www.ebi.ac.uk/pdbsum/4hjk PDBsum]</span></td></tr>
		+	</table>

-	~~{{STRUCTURE_4hjk\| PDB~~=~~4hjk \| SCENE= }}~~	+	==See Also==
-		+	*[[Ubiquitin\|Ubiquitin]]
-	~~===U7Ub7 Disulfide variant~~===	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	[[~~4hjk~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Murray, J M.]]	+	[[Category: Murray, J M]]
-	[[Category: Rouge, L.]]	+	[[Category: Rouge, L]]
	[[Category: Cytoplasmic]]		[[Category: Cytoplasmic]]
	[[Category: Signaling protein-inhibitor complex]]		[[Category: Signaling protein-inhibitor complex]]
	[[Category: Usp7]]		[[Category: Usp7]]

OCA at 09:48, 21 November 2012

OCA — Wed, 21 Nov 2012 09:48:59 GMT

←Older revision		Revision as of 09:48, 21 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hjk.jpg\|left\|200px]]

-	~~The entry~~ 4hjk ~~is ON HOLD~~	+	{{STRUCTURE_4hjk\| PDB=4hjk \| SCENE= }}

-	~~Authors: Murray, J.M., Rouge, L.~~	+	===U7Ub7 Disulfide variant===

-	~~Description~~: ~~U7Ub7 Disulfide variant~~	+
		+	==About this Structure==
		+	[[4hjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJK OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Murray, J M.]]
		+	[[Category: Rouge, L.]]
		+	[[Category: Cytoplasmic]]
		+	[[Category: Signaling protein-inhibitor complex]]
		+	[[Category: Usp7]]

OCA at 08:39, 31 October 2012

OCA — Wed, 31 Oct 2012 08:39:46 GMT

←Older revision		Revision as of 08:39, 31 October 2012
Line 3:		Line 3:
	The entry 4hjk is ON HOLD		The entry 4hjk is ON HOLD

-	Authors: Murray, J.M., Rouge, L	+	Authors: Murray, J.M., Rouge, L.

	Description: U7Ub7 Disulfide variant		Description: U7Ub7 Disulfide variant

OCA: Protected "4hjk" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2012 07:12:05 GMT

Protected "4hjk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hjk is ON HOLD Authors: Murray, J.M., Rouge, L Description: U7Ub7 Disulfide variant

OCA — Wed, 24 Oct 2012 07:12:04 GMT

New page: '''Unreleased structure''' The entry 4hjk is ON HOLD Authors: Murray, J.M., Rouge, L Description: U7Ub7 Disulfide variant

New page

'''Unreleased structure'''

The entry 4hjk is ON HOLD

Authors: Murray, J.M., Rouge, L

Description: U7Ub7 Disulfide variant