4hlc - Revision history

OCA at 06:48, 3 April 2024

OCA — Wed, 03 Apr 2024 06:48:39 GMT

←Older revision		Revision as of 06:48, 3 April 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).		[https://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Previously, we have described the first potent and selective inhibitors of Gram-positive TMK, leading to in vivo validation of the target. Here, a structure-guided design approach based on the initial series led to the discovery of novel sulfonylpiperidine inhibitors of TMK. Formation of hydrogen bonds with Arg48 in Staphylococcus aureus TMK was key to obtaining excellent enzyme affinity, as verified by protein crystallography. Replacement of a methylene linker in the series by a sulfonamide was accomplished with retention of binding conformation. Further optimization of logD yielded phenol derivative 11, a potent inhibitor of TMK showing excellent MICs against a broad spectrum of Gram-positive bacteria and >10(5) selectivity versus the human TMK homologue.
-
-	Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).,Martinez-Botella G, Loch JT, Green OM, Kawatkar SP, Olivier NB, Boriack-Sjodin PA, Keating TA Bioorg Med Chem Lett. 2013 Jan 1;23(1):169-73. doi: 10.1016/j.bmcl.2012.10.128., Epub 2012 Nov 5. PMID:23206863<ref>PMID:23206863</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hlc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Thymidylate kinase 3D structures\|Thymidylate kinase 3D structures]]		*[[Thymidylate kinase 3D structures\|Thymidylate kinase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:27, 29 November 2023

OCA — Wed, 29 Nov 2023 14:27:18 GMT

←Older revision		Revision as of 14:27, 29 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [https://pdbe.org/4hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [https://www.ebi.ac.uk/pdbsum/4hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [https://pdbe.org/4hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [https://www.ebi.ac.uk/pdbsum/4hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:24, 3 November 2022

OCA — Thu, 03 Nov 2022 08:24:26 GMT

←Older revision		Revision as of 08:24, 3 November 2022
Line 1:		Line 1:

	==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5==		==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5==
-	<StructureSection load='4hlc' size='340' side='right' caption='[[4hlc]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4hlc' size='340' side='right'caption='[[4hlc]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staar Staar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gfd\|4gfd]], [[4hdc\|4hdc]], [[4hej\|4hej]], [[4hld\|4hld]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [https://pdbe.org/4hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [https://www.ebi.ac.uk/pdbsum/4hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlc ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [~~http~~://pdbe.org/4hlc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hlc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).	+	[https://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Thymidylate kinase\|Thymidylate kinase]]	+	*[[Thymidylate kinase 3D structures\|Thymidylate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staar~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~DTMP kinase~~]]	+	[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
-	[[Category: Boriack-Sjodin, A]]	+	[[Category: Boriack-Sjodin A]]
-	[[Category: Olivier, N]]	+	[[Category: Olivier N]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mrsa]]~~	+
-	~~[[Category: Pipiridine]]~~	+
-	~~[[Category: Thymidylate kinase]]~~	+
-	~~[[Category: Tmk]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 19:51, 15 December 2016

OCA — Thu, 15 Dec 2016 19:51:38 GMT

←Older revision		Revision as of 19:51, 15 December 2016
Line 1:		Line 1:
		+
	==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5==		==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5==
	<StructureSection load='4hlc' size='340' side='right' caption='[[4hlc]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4hlc' size='340' side='right' caption='[[4hlc]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gfd\|4gfd]], [[4hdc\|4hdc]], [[4hej\|4hej]], [[4hld\|4hld]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gfd\|4gfd]], [[4hdc\|4hdc]], [[4hej\|4hej]], [[4hld\|4hld]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 ~~Staphylococcus aureus subsp. aureus MRSA252~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [http://www.ebi.ac.uk/pdbsum/4hlc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [http://pdbe.org/4hlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [http://www.ebi.ac.uk/pdbsum/4hlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hlc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus aureus subsp. aureus mrsa252~~]]	+	[[Category: Staar]]
	[[Category: DTMP kinase]]		[[Category: DTMP kinase]]
	[[Category: Boriack-Sjodin, A]]		[[Category: Boriack-Sjodin, A]]

OCA at 09:12, 10 December 2014

OCA — Wed, 10 Dec 2014 09:12:12 GMT

←Older revision		Revision as of 09:12, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hlc.~~png~~\|~~left~~\|~~200px~~]]	+	==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5==
		+	<StructureSection load='4hlc' size='340' side='right' caption='[[4hlc]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T05:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]SULFONYL}-2-(3-METHYLPHENOXY)BENZOIC+ACID'>T05</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gfd\|4gfd]], [[4hdc\|4hdc]], [[4hej\|4hej]], [[4hld\|4hld]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAR0483, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 Staphylococcus aureus subsp. aureus MRSA252])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlc RCSB], [http://www.ebi.ac.uk/pdbsum/4hlc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thymidylate kinase (TMK) is an essential enzyme for DNA synthesis in bacteria, phosphorylating deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), and thus is a potential new antibacterial drug target. Previously, we have described the first potent and selective inhibitors of Gram-positive TMK, leading to in vivo validation of the target. Here, a structure-guided design approach based on the initial series led to the discovery of novel sulfonylpiperidine inhibitors of TMK. Formation of hydrogen bonds with Arg48 in Staphylococcus aureus TMK was key to obtaining excellent enzyme affinity, as verified by protein crystallography. Replacement of a methylene linker in the series by a sulfonamide was accomplished with retention of binding conformation. Further optimization of logD yielded phenol derivative 11, a potent inhibitor of TMK showing excellent MICs against a broad spectrum of Gram-positive bacteria and >10(5) selectivity versus the human TMK homologue.

-	~~{{STRUCTURE_4hlc\| PDB=4hlc \| SCENE= }}~~	+	Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).,Martinez-Botella G, Loch JT, Green OM, Kawatkar SP, Olivier NB, Boriack-Sjodin PA, Keating TA Bioorg Med Chem Lett. 2013 Jan 1;23(1):169-73. doi: 10.1016/j.bmcl.2012.10.128., Epub 2012 Nov 5. PMID:23206863<ref>PMID:23206863</ref>

-	~~===Sulfonylpiperidines as Novel~~, ~~Antibacterial Inhibitors~~ of ~~Gram-Positive Thymidylate Kinase (TMK): Compound 5===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23206863}}~~	+	==See Also==
-		+	*[[Thymidylate kinase\|Thymidylate kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4hlc~~]] ~~is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA].	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Staphylococcus aureus subsp. aureus mrsa252]]		[[Category: Staphylococcus aureus subsp. aureus mrsa252]]
	[[Category: DTMP kinase]]		[[Category: DTMP kinase]]
-	[[Category: Boriack-Sjodin, A.]]	+	[[Category: Boriack-Sjodin, A]]
-	[[Category: Olivier, N.]]	+	[[Category: Olivier, N]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Mrsa]]		[[Category: Mrsa]]

OCA at 07:12, 2 January 2013

OCA — Wed, 02 Jan 2013 07:12:54 GMT

←Older revision		Revision as of 07:12, 2 January 2013
Line 1:		Line 1:
-	[[Image:4hlc.~~jpg~~\|left\|200px]]	+	[[Image:4hlc.png\|left\|200px]]

	{{STRUCTURE_4hlc\| PDB=4hlc \| SCENE= }}		{{STRUCTURE_4hlc\| PDB=4hlc \| SCENE= }}
Line 5:		Line 5:
	===Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5===		===Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5===

		+	{{ABSTRACT_PUBMED_23206863}}

	==About this Structure==		==About this Structure==

OCA at 09:29, 31 October 2012

OCA — Wed, 31 Oct 2012 09:29:02 GMT

←Older revision		Revision as of 09:29, 31 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hlc.jpg\|left\|200px]]

-	~~The entry~~ 4hlc ~~is ON HOLD~~	+	{{STRUCTURE_4hlc\| PDB=4hlc \| SCENE= }}

-	~~Authors~~: ~~Boriack-Sjodin, A., Olivier, N.~~	+	===Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5===

-	~~Description~~: ~~Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram~~-~~Positive Thymidylate~~ Kinase ~~(TMK)~~: ~~Compound 5~~	+
		+	==About this Structure==
		+	[[4hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLC OCA].
		+	[[Category: Staphylococcus aureus subsp. aureus mrsa252]]
		+	[[Category: DTMP kinase]]
		+	[[Category: Boriack-Sjodin, A.]]
		+	[[Category: Olivier, N.]]
		+	[[Category: Kinase]]
		+	[[Category: Mrsa]]
		+	[[Category: Pipiridine]]
		+	[[Category: Thymidylate kinase]]
		+	[[Category: Tmk]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "4hlc" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2012 07:13:55 GMT

Protected "4hlc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:13, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hlc is ON HOLD Authors: Boriack-Sjodin, A., Olivier, N. Description: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymi...

OCA — Wed, 24 Oct 2012 07:13:54 GMT

New page: '''Unreleased structure''' The entry 4hlc is ON HOLD Authors: Boriack-Sjodin, A., Olivier, N. Description: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymi...

New page

'''Unreleased structure'''

The entry 4hlc is ON HOLD

Authors: Boriack-Sjodin, A., Olivier, N.

Description: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 5