4hlf - Revision history

OCA at 15:08, 20 September 2023

OCA — Wed, 20 Sep 2023 15:08:01 GMT

←Older revision		Revision as of 15:08, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [https://pdbe.org/4hlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [https://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [https://pdbe.org/4hlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [https://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:24, 3 November 2022

OCA — Thu, 03 Nov 2022 08:24:34 GMT

←Older revision		Revision as of 08:24, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==		==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==
-	<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4hlf' size='340' side='right'caption='[[4hlf]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HLF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u9h\|3u9h]], [[3u9y\|3u9y]], [[3ua9\|3ua9]], [[4hki\|4hki]], [[4hkk\|4hkk]], [[4hkn\|4hkn]], [[4hl5\|4hl5]], [[4hlg\|4hlg]], [[4hlh\|4hlh]], [[4hlk\|4hlk]], [[4hlm\|4hlm]], [[4hmh\|4hmh]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [https://pdbe.org/4hlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [https://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [~~http~~://pdbe.org/4hlf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>	+	[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Haikarainen, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lehtio, L~~]]	+	[[Category: Haikarainen T]]
-	[[Category: ~~Narwal, M~~]]	+	[[Category: Lehtio L]]
-	[[Category: ~~Adp-ribosylation]]~~	+	[[Category: Narwal M]]
-	~~[[Category: Diphtheria toxin like fold]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:02, 5 August 2016

OCA — Fri, 05 Aug 2016 06:02:09 GMT

←Older revision		Revision as of 06:02, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==		==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==
	<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u9h\|3u9h]], [[3u9y\|3u9y]], [[3ua9\|3ua9]], [[4hki\|4hki]], [[4hkk\|4hkk]], [[4hkn\|4hkn]], [[4hl5\|4hl5]], [[4hlg\|4hlg]], [[4hlh\|4hlh]], [[4hlk\|4hlk]], [[4hlm\|4hlm]], [[4hmh\|4hmh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u9h\|3u9h]], [[3u9y\|3u9y]], [[3ua9\|3ua9]], [[4hki\|4hki]], [[4hkk\|4hkk]], [[4hkn\|4hkn]], [[4hl5\|4hl5]], [[4hlg\|4hlg]], [[4hlh\|4hlh]], [[4hlk\|4hlk]], [[4hlm\|4hlm]], [[4hmh\|4hmh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://pdbe.org/4hlf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hlf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 23:39, 24 December 2014

OCA — Wed, 24 Dec 2014 23:39:35 GMT

←Older revision		Revision as of 23:39, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:49, 21 December 2014

OCA — Sun, 21 Dec 2014 12:49:40 GMT

←Older revision		Revision as of 12:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hlf\| PDB=4hlf \| SCENE= }}~~	+	==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==
-	===Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone===	+	<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23574272}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u9h\|3u9h]], [[3u9y\|3u9y]], [[3ua9\|3ua9]], [[4hki\|4hki]], [[4hkk\|4hkk]], [[4hkn\|4hkn]], [[4hl5\|4hl5]], [[4hlg\|4hlg]], [[4hlh\|4hlh]], [[4hlk\|4hlk]], [[4hlm\|4hlm]], [[4hmh\|4hmh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Flavonoids are known for their beneficial effects on human health, and therefore the therapeutic potential of these compounds have been extensively studied. Flavone has been previously identified as a tankyrase inhibitor, and to further elucidate whether tankyrases would be inhibited by other flavonoids, we performed a systematic screening of tankyrase 2 inhibitory activity using 500 natural and naturally derived flavonoids covering nine different flavonoid classes. All identified tankyrase inhibitors were flavones. We report crystal structures of all the hit compounds in complex with the catalytic domain of human tankyrase 2. Flavone derivatives in all 10 crystal structures bind to the nicotinamide binding site of tankyrase 2. Potencies of the active flavones toward tankyrases vary between 50 nM and 1.1 muM, and flavones show up to 200-fold selectivity for tankyrases over ARTD1. The molecular details of the interactions revealed by cocrystal structures efficiently describe the properties of potent flavone derivatives inhibiting tankyrases.

-	~~==Function==~~	+	Screening and Structural Analysis of Flavones Inhibiting Tankyrases.,Narwal M, Haikarainen T, Fallarero A, Vuorela PM, Lehtio L J Med Chem. 2013 Apr 24. PMID:23574272<ref>PMID:23574272</ref>
-	~~[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length~~ and ~~vesicle trafficking~~. ~~Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2~~, ~~2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146~~, ~~which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3~~, ~~followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1~~, ~~thereby contributing to the regulation of telomere length~~. ~~May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles~~.~~<ref>~~PMID:~~11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref>~~ <ref>PMID:~~21478859~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hlf]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023574272</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Haikarainen, T.]]	+	[[Category: Haikarainen, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Narwal, M.]]	+	[[Category: Narwal, M]]
	[[Category: Adp-ribosylation]]		[[Category: Adp-ribosylation]]
	[[Category: Diphtheria toxin like fold]]		[[Category: Diphtheria toxin like fold]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:36, 20 June 2013

OCA — Thu, 20 Jun 2013 06:36:36 GMT

←Older revision		Revision as of 06:36, 20 June 2013
Line 10:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023574272</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Haikarainen, T.]]		[[Category: Haikarainen, T.]]

OCA at 06:48, 8 May 2013

OCA — Wed, 08 May 2013 06:48:43 GMT

←Older revision		Revision as of 06:48, 8 May 2013
Line 1:		Line 1:
-	[[Image:4hlf.jpg\|left\|200px]]
-
	{{STRUCTURE_4hlf\| PDB=4hlf \| SCENE= }}		{{STRUCTURE_4hlf\| PDB=4hlf \| SCENE= }}
-
	===Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone===		===Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone===
		+	{{ABSTRACT_PUBMED_23574272}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>

	==About this Structure==		==About this Structure==
	[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA].		[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Haikarainen, T.]]		[[Category: Haikarainen, T.]]

OCA at 09:29, 31 October 2012

OCA — Wed, 31 Oct 2012 09:29:16 GMT

←Older revision		Revision as of 09:29, 31 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hlf.jpg\|left\|200px]]

-	~~The entry~~ 4hlf ~~is ON HOLD~~	+	{{STRUCTURE_4hlf\| PDB=4hlf \| SCENE= }}

-	~~Authors: Narwal~~, M., ~~Haikarainen, T., Lehtio, L.~~	+	===Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone===

-	~~Description: Crystal~~ structure ~~of Tankyrase 2 in complex~~ with 7,3',4'-~~Trihydroxyflavone~~	+
		+	==About this Structure==
		+	[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Haikarainen, T.]]
		+	[[Category: Lehtio, L.]]
		+	[[Category: Narwal, M.]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Diphtheria toxin like fold]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Transferase]]

OCA: Protected "4hlf" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2012 07:14:01 GMT

Protected "4hlf" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:14, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hlf is ON HOLD Authors: Narwal, M., Haikarainen, T., Lehtio, L. Description: Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyfl...

OCA — Wed, 24 Oct 2012 07:14:00 GMT

New page: '''Unreleased structure''' The entry 4hlf is ON HOLD Authors: Narwal, M., Haikarainen, T., Lehtio, L. Description: Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyfl...

New page

'''Unreleased structure'''

The entry 4hlf is ON HOLD

Authors: Narwal, M., Haikarainen, T., Lehtio, L.

Description: Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone