4hmy - Revision history

OCA at 15:08, 20 September 2023

OCA — Wed, 20 Sep 2023 15:08:30 GMT

←Older revision		Revision as of 15:08, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [https://pdbe.org/4hmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [https://www.ebi.ac.uk/pdbsum/4hmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [https://pdbe.org/4hmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [https://www.ebi.ac.uk/pdbsum/4hmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:27, 3 November 2022

OCA — Thu, 03 Nov 2022 08:27:36 GMT

←Older revision		Revision as of 08:27, 3 November 2022
Line 1:		Line 1:

	==Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1==		==Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1==
-	<StructureSection load='4hmy' size='340' side='right' caption='[[4hmy]], [[Resolution\|resolution]] 7.00Å' scene=''>	+	<StructureSection load='4hmy' size='340' side='right'caption='[[4hmy]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HMY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adtg, Ap1g1, Clapg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), ADTB1, AP1B1, BAM22, CLAPB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Ap1m1, Cltnm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), AP1S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [https://pdbe.org/4hmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [https://www.ebi.ac.uk/pdbsum/4hmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [~~http~~://pdbe.org/4hmy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hmy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmy ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/AP1S3_HUMAN AP1S3_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/AP1S3_HUMAN AP1S3_HUMAN]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).<ref>PMID:24791904</ref> [[http://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1M1_MOUSE AP1M1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1B1_HUMAN AP1B1_HUMAN]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.	+	[https://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Adaptin\|Adaptin]]	+	*[[Adaptin 3D structures\|Adaptin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bonifacino, J S~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Canagarajah, B J~~]]	+	[[Category: Bonifacino JS]]
-	[[Category: ~~Farias, G G~~]]	+	[[Category: Canagarajah BJ]]
-	[[Category: ~~Hurley, J H~~]]	+	[[Category: Farias GG]]
-	[[Category: ~~Ren, X~~]]	+	[[Category: Hurley JH]]
-	[[Category: ~~Arf1 gtpase activation]]~~	+	[[Category: Ren X]]
-	~~[[Category: Arf1 gtpase binding]]~~	+
-	~~[[Category: Protein trafficking]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Trans-golgi membrane~~]]	+

OCA at 18:42, 4 August 2016

OCA — Thu, 04 Aug 2016 18:42:53 GMT

←Older revision		Revision as of 18:42, 4 August 2016
Line 1:		Line 1:
		+
	==Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1==		==Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1==
	<StructureSection load='4hmy' size='340' side='right' caption='[[4hmy]], [[Resolution\|resolution]] 7.00Å' scene=''>		<StructureSection load='4hmy' size='340' side='right' caption='[[4hmy]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HMY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HMY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adtg, Ap1g1, Clapg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), ADTB1, AP1B1, BAM22, CLAPB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Ap1m1, Cltnm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), AP1S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), ARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adtg, Ap1g1, Clapg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), ADTB1, AP1B1, BAM22, CLAPB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Ap1m1, Cltnm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), AP1S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [http://www.ebi.ac.uk/pdbsum/4hmy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [http://pdbe.org/4hmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [http://www.ebi.ac.uk/pdbsum/4hmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/AP1S3_HUMAN AP1S3_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1M1_MOUSE AP1M1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.	+	[[http://www.uniprot.org/uniprot/AP1S3_HUMAN AP1S3_HUMAN]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).<ref>PMID:24791904</ref> [[http://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1M1_MOUSE AP1M1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1B1_HUMAN AP1B1_HUMAN]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hmy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bonifacino, J S]]		[[Category: Bonifacino, J S]]
	[[Category: Canagarajah, B J]]		[[Category: Canagarajah, B J]]

OCA at 12:03, 25 December 2014

OCA — Thu, 25 Dec 2014 12:03:21 GMT

←Older revision		Revision as of 12:03, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [http://www.ebi.ac.uk/pdbsum/4hmy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [http://www.ebi.ac.uk/pdbsum/4hmy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/AP1M1_MOUSE AP1M1_MOUSE]] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:25, 10 December 2014

OCA — Wed, 10 Dec 2014 09:25:43 GMT

←Older revision		Revision as of 09:25, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hmy.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1==
		+	<StructureSection load='4hmy' size='340' side='right' caption='[[4hmy]], [[Resolution\|resolution]] 7.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hmy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HMY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adtg, Ap1g1, Clapg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), ADTB1, AP1B1, BAM22, CLAPB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Ap1m1, Cltnm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), AP1S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ARF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hmy RCSB], [http://www.ebi.ac.uk/pdbsum/4hmy PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AP-1 is a clathrin adaptor complex that sorts cargo between the trans-Golgi network and endosomes. AP-1 recruitment to these compartments requires Arf1-GTP. The crystal structure of the tetrameric core of AP-1 in complex with Arf1-GTP, together with biochemical analyses, shows that Arf1 activates cargo binding by unlocking AP-1. Unlocking is driven by two molecules of Arf1 that bridge two copies of AP-1 at two interaction sites. The GTP-dependent switch I and II regions of Arf1 bind to the N terminus of the beta1 subunit of one AP-1 complex, while the back side of Arf1 binds to the central part of the gamma subunit trunk of a second AP-1 complex. A third Arf1 interaction site near the N terminus of the gamma subunit is important for recruitment, but not activation. These observations lead to a model for the recruitment and activation of AP-1 by Arf1.

-	~~{{STRUCTURE_4hmy\| PDB=4hmy \| SCENE= }}~~	+	Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1.,Ren X, Farias GG, Canagarajah BJ, Bonifacino JS, Hurley JH Cell. 2013 Feb 14;152(4):755-67. doi: 10.1016/j.cell.2012.12.042. PMID:23415225<ref>PMID:23415225</ref>

-	~~===Structural basis for recruitment and activation~~ of the ~~AP-1 clathrin adaptor complex by Arf1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23415225}}~~	+	==See Also==
-		+	*[[Adaptin\|Adaptin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4hmy~~]] ~~is a 5 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA].	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bonifacino, J S.]]	+	[[Category: Bonifacino, J S]]
-	[[Category: Canagarajah, B J.]]	+	[[Category: Canagarajah, B J]]
-	[[Category: Farias, G G.]]	+	[[Category: Farias, G G]]
-	[[Category: Hurley, J H.]]	+	[[Category: Hurley, J H]]
-	[[Category: Ren, X.]]	+	[[Category: Ren, X]]
	[[Category: Arf1 gtpase activation]]		[[Category: Arf1 gtpase activation]]
	[[Category: Arf1 gtpase binding]]		[[Category: Arf1 gtpase binding]]

OCA at 14:15, 6 March 2013

OCA — Wed, 06 Mar 2013 14:15:29 GMT

←Older revision		Revision as of 14:15, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hmy.jpg\|left\|200px]]

-	~~The entry~~ 4hmy ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hmy\| PDB=4hmy \| SCENE= }}

-	~~Authors: Ren, X., Farias, G.G., Canagarajah, B.J., Bonifacino, J.S., Hurley, J.H.~~	+	===Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1===

-	~~Description~~: ~~Structural basis for recruitment~~ and ~~activation of the AP~~-~~1 clathrin adaptor complex by~~ Arf1	+	{{ABSTRACT_PUBMED_23415225}}
		+
		+	==About this Structure==
		+	[[4hmy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMY OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Bonifacino, J S.]]
		+	[[Category: Canagarajah, B J.]]
		+	[[Category: Farias, G G.]]
		+	[[Category: Hurley, J H.]]
		+	[[Category: Ren, X.]]
		+	[[Category: Arf1 gtpase activation]]
		+	[[Category: Arf1 gtpase binding]]
		+	[[Category: Protein trafficking]]
		+	[[Category: Protein transport]]
		+	[[Category: Trans-golgi membrane]]

OCA at 06:16, 14 November 2012

OCA — Wed, 14 Nov 2012 06:16:24 GMT

←Older revision		Revision as of 06:16, 14 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hmy is ON HOLD	+	The entry 4hmy is ON HOLD until Paper Publication

	Authors: Ren, X., Farias, G.G., Canagarajah, B.J., Bonifacino, J.S., Hurley, J.H.		Authors: Ren, X., Farias, G.G., Canagarajah, B.J., Bonifacino, J.S., Hurley, J.H.

	Description: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1		Description: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1

OCA at 08:41, 31 October 2012

OCA — Wed, 31 Oct 2012 08:41:07 GMT

←Older revision		Revision as of 08:41, 31 October 2012
Line 3:		Line 3:
	The entry 4hmy is ON HOLD		The entry 4hmy is ON HOLD

-	Authors: Ren, X., Farias, G. G., Canagarajah, B. J., Bonifacino, J. S., Hurley, J. H.	+	Authors: Ren, X., Farias, G.G., Canagarajah, B.J., Bonifacino, J.S., Hurley, J.H.

	Description: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1		Description: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1

OCA: Protected "4hmy" [edit=sysop:move=sysop]

OCA — Wed, 24 Oct 2012 07:15:37 GMT

Protected "4hmy" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 24 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hmy is ON HOLD Authors: Ren, X., Farias, G. G., Canagarajah, B. J., Bonifacino, J. S., Hurley, J. H. Description: Structural basis for recruitment...

OCA — Wed, 24 Oct 2012 07:15:36 GMT

New page: '''Unreleased structure''' The entry 4hmy is ON HOLD Authors: Ren, X., Farias, G. G., Canagarajah, B. J., Bonifacino, J. S., Hurley, J. H. Description: Structural basis for recruitment...

New page

'''Unreleased structure'''

The entry 4hmy is ON HOLD

Authors: Ren, X., Farias, G. G., Canagarajah, B. J., Bonifacino, J. S., Hurley, J. H.

Description: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1