4hna - Revision history

OCA at 15:08, 20 September 2023

OCA — Wed, 20 Sep 2023 15:08:37 GMT

←Older revision		Revision as of 15:08, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.19Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [https://pdbe.org/4hna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [https://www.ebi.ac.uk/pdbsum/4hna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hna ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [https://pdbe.org/4hna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [https://www.ebi.ac.uk/pdbsum/4hna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hna ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:28, 3 November 2022

OCA — Thu, 03 Nov 2022 08:28:02 GMT

←Older revision		Revision as of 08:28, 3 November 2022
Line 1:		Line 1:

	==Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN==		==Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN==
-	<StructureSection load='4hna' size='340' side='right' caption='[[4hna]], [[Resolution\|resolution]] 3.19Å' scene=''>	+	<StructureSection load='4hna' size='340' side='right'caption='[[4hna]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~], [~~http~~://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF5B, KNS, KNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [https://pdbe.org/4hna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [https://www.ebi.ac.uk/pdbsum/4hna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hna ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [~~http~~://pdbe.org/4hna PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hna PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hna ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity). [[http~~://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801] [[http://www.uniprot.org/uniprot/D0VWY9_SHEEP D0VWY9_SHEEP]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505]	+	[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hna" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hna" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
		+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Gigant, B]]	+	[[Category: Gigant B]]
-	[[Category: Knossow, M]]	+	[[Category: Knossow M]]
-	~~[[Category: Alpha-tubulin]]~~	+
-	~~[[Category: Beta-tubulin]]~~	+
-	~~[[Category: Darpin]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Tubulin~~]]	+

OCA at 08:42, 15 November 2017

OCA — Wed, 15 Nov 2017 08:42:56 GMT

←Older revision		Revision as of 08:42, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4hna" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hna" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Kinesin\|Kinesin]]
-	*[[Tubulin\|Tubulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:38, 5 August 2016

OCA — Fri, 05 Aug 2016 14:38:12 GMT

←Older revision		Revision as of 14:38, 5 August 2016
Line 1:		Line 1:
		+
	==Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN==		==Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN==
	<StructureSection load='4hna' size='340' side='right' caption='[[4hna]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='4hna' size='340' side='right' caption='[[4hna]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Alfaropsis_roxburghiana Alfaropsis roxburghiana~~], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/~~Synthetic_construct~~ Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF5B, KNS, KNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~139932 Alfaropsis roxburghiana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF5B, KNS, KNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [http://www.ebi.ac.uk/pdbsum/4hna PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [http://pdbe.org/4hna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [http://www.ebi.ac.uk/pdbsum/4hna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hna ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).	+	[[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity). [[http://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801] [[http://www.uniprot.org/uniprot/D0VWY9_SHEEP D0VWY9_SHEEP]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hna" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alfaropsis roxburghiana~~]]	+	[[Category: Human]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
-	[[Category: Synthetic construct]]	+	[[Category: Synthetic construct sequences]]
	[[Category: Gigant, B]]		[[Category: Gigant, B]]
	[[Category: Knossow, M]]		[[Category: Knossow, M]]

OCA at 03:18, 25 December 2014

OCA — Thu, 25 Dec 2014 03:18:47 GMT

←Older revision		Revision as of 03:18, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [http://www.ebi.ac.uk/pdbsum/4hna PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [http://www.ebi.ac.uk/pdbsum/4hna PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:25, 21 December 2014

OCA — Sun, 21 Dec 2014 12:25:16 GMT

←Older revision		Revision as of 12:25, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hna\| PDB=4hna \| SCENE= }}~~	+	==Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN==
-	===Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN===	+	<StructureSection load='4hna' size='340' side='right' caption='[[4hna]], [[Resolution\|resolution]] 3.19Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23872990}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF5B, KNS, KNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139932 Alfaropsis roxburghiana])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hna RCSB], [http://www.ebi.ac.uk/pdbsum/4hna PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The typical function of kinesins is to transport cargo along microtubules. Binding of ATP to microtubule-attached motile kinesins leads to cargo displacement. To better understand the nature of the conformational changes that lead to the power stroke that moves a kinesin's load along a microtubule, we determined the X-ray structure of human kinesin-1 bound to alphabeta-tubulin. The structure defines the mechanism of microtubule-stimulated ATP hydrolysis, which releases the kinesin motor domain from microtubules. It also reveals the structural linkages that connect the ATP nucleotide to the kinesin neck linker, a 15-amino acid segment C terminal to the catalytic core of the motor domain, to result in the power stroke. ATP binding to the microtubule-bound kinesin favors neck-linker docking. This biases the attachment of kinesin's second head in the direction of the movement, thus initiating each of the steps taken.

-	~~==Function==~~	+	Structure of a kinesin-tubulin complex and implications for kinesin motility.,Gigant B, Wang W, Dreier B, Jiang Q, Pecqueur L, Pluckthun A, Wang C, Knossow M Nat Struct Mol Biol. 2013 Aug;20(8):1001-7. doi: 10.1038/nsmb.2624. Epub 2013 Jul, 21. PMID:23872990<ref>PMID:23872990</ref>
-	~~[[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution~~ of ~~mitochondria~~ and ~~lysosomes~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hna]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana]~~, ~~[http://en~~.~~wikipedia~~.~~org/wiki/Ovis_aries Ovis aries] and [http://en~~.~~wikipedia.org~~/~~wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA].~~	+	</div>

	==See Also==		==See Also==
		+	*[[Kinesin\|Kinesin]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023872990</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alfaropsis roxburghiana]]		[[Category: Alfaropsis roxburghiana]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
	[[Category: Synthetic construct]]		[[Category: Synthetic construct]]
-	[[Category: Gigant, B.]]	+	[[Category: Gigant, B]]
-	[[Category: Knossow, M.]]	+	[[Category: Knossow, M]]
	[[Category: Alpha-tubulin]]		[[Category: Alpha-tubulin]]
	[[Category: Beta-tubulin]]		[[Category: Beta-tubulin]]

OCA at 08:20, 21 August 2013

OCA — Wed, 21 Aug 2013 08:20:41 GMT

←Older revision		Revision as of 08:20, 21 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4hna\| PDB=4hna \| SCENE= }}		{{STRUCTURE_4hna\| PDB=4hna \| SCENE= }}
	===Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN===		===Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN===
		+	{{ABSTRACT_PUBMED_23872990}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA].		[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA].
		+
		+	==See Also==
		+	*[[Tubulin\|Tubulin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023872990</ref><references group="xtra"/><references/>
	[[Category: Alfaropsis roxburghiana]]		[[Category: Alfaropsis roxburghiana]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]

OCA at 21:03, 19 June 2013

OCA — Wed, 19 Jun 2013 21:03:44 GMT

←Older revision		Revision as of 21:03, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hna\| PDB=4hna \| SCENE= }}
		+	===Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN===

-	~~The entry 4hna is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).

-	~~Authors~~: Gigant, B., Knossow, M.	+	==About this Structure==
-		+	[[4hna]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfaropsis_roxburghiana Alfaropsis roxburghiana], [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNA OCA].
-	~~Description~~: Tubulin ~~complex~~	+	[[Category: Alfaropsis roxburghiana]]
		+	[[Category: Ovis aries]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Gigant, B.]]
		+	[[Category: Knossow, M.]]
		+	[[Category: Alpha-tubulin]]
		+	[[Category: Beta-tubulin]]
		+	[[Category: Darpin]]
		+	[[Category: Gtpase]]
		+	[[Category: Kinesin]]
		+	[[Category: Microtubule]]
		+	[[Category: Motor protein]]
		+	[[Category: Tubulin]]

OCA at 13:23, 8 November 2012

OCA — Thu, 08 Nov 2012 13:23:28 GMT

←Older revision		Revision as of 13:23, 8 November 2012
Line 5:		Line 5:
	Authors: Gigant, B., Knossow, M.		Authors: Gigant, B., Knossow, M.

-	Description: ~~TUBULIN COMPLEX~~	+	Description: Tubulin complex

OCA: Protected "4hna" [edit=sysop:move=sysop]

OCA — Wed, 31 Oct 2012 08:41:16 GMT

Protected "4hna" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:41, 31 October 2012