4hnm - Revision history

OCA at 08:28, 3 November 2022

OCA — Thu, 03 Nov 2022 08:28:25 GMT

←Older revision		Revision as of 08:28, 3 November 2022
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	==Crystal structure of human catenin-beta-like 1 56 kDa fragment==		==Crystal structure of human catenin-beta-like 1 56 kDa fragment==
-	<StructureSection load='4hnm' size='340' side='right' caption='[[4hnm]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4hnm' size='340' side='right'caption='[[4hnm]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hnm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNM FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf33, CTNNBL1, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [https://pdbe.org/4hnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [https://www.ebi.ac.uk/pdbsum/4hnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [~~http~~://pdbe.org/4hnm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hnm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>	+	[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Du, Z]]	+	[[Category: Large Structures]]
-	[[Category: Huang, X]]	+	[[Category: Du Z]]
-	[[Category: Wang, G]]	+	[[Category: Huang X]]
-	[[Category: Wu, Y]]	+	[[Category: Wang G]]
-	~~[[Category: All alpha-helical]]~~	+	[[Category: Wu Y]]
-	~~[[Category: Armadillo repeat]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 16:50, 5 August 2016

OCA — Fri, 05 Aug 2016 16:50:08 GMT

←Older revision		Revision as of 16:50, 5 August 2016
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		+
	==Crystal structure of human catenin-beta-like 1 56 kDa fragment==		==Crystal structure of human catenin-beta-like 1 56 kDa fragment==
	<StructureSection load='4hnm' size='340' side='right' caption='[[4hnm]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4hnm' size='340' side='right' caption='[[4hnm]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNM FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf33, CTNNBL1, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf33, CTNNBL1, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [http://www.ebi.ac.uk/pdbsum/4hnm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [http://pdbe.org/4hnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [http://www.ebi.ac.uk/pdbsum/4hnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hnm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Du, Z]]		[[Category: Du, Z]]
	[[Category: Huang, X]]		[[Category: Huang, X]]

OCA at 04:09, 25 December 2014

OCA — Thu, 25 Dec 2014 04:09:40 GMT

←Older revision		Revision as of 04:09, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [http://www.ebi.ac.uk/pdbsum/4hnm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [http://www.ebi.ac.uk/pdbsum/4hnm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:11, 21 December 2014

OCA — Sun, 21 Dec 2014 13:11:37 GMT

←Older revision		Revision as of 13:11, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hnm\| PDB=4hnm \| SCENE= }}~~	+	==Crystal structure of human catenin-beta-like 1 56 kDa fragment==
-	===Crystal structure of human catenin-beta-like 1 56 kDa fragment===	+	<StructureSection load='4hnm' size='340' side='right' caption='[[4hnm]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23897482}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNM FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf33, CTNNBL1, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hnm RCSB], [http://www.ebi.ac.uk/pdbsum/4hnm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Catenin-beta-like protein 1 (CTNNBL1) is a highly conserved protein with multiple functions, one of which is to act as an interaction partner of the antibody-diversification enzyme activation-induced cytidine deaminase (AID) for its nuclear import and subnuclear trafficking. Here, the crystal structure of full-length human CTNNBL1 is reported. The protein contains six armadillo (ARM) repeats that pack into a superhelical ARM domain. This ARM domain is unique within the ARM protein family owing to the presence of several unusual structural features. Moreover, CTNNBL1 contains significant and novel non-ARM structures flanking both ends of the central ARM domain. A strong continuous hydrophobic core runs through the whole structure, indicating that the ARM and non-ARM structures fold together to form an integral structure. This structure defines a highly restrictive and discriminatory protein-binding groove that is not observed in other ARM proteins. The presence of a cluster of histidine residues in the groove implies a pH-sensitive histidine-mediated mechanism that may regulate protein binding activity. The many unique structural features of CTNNBL1 establish it as a distinct member of the ARM protein family. The structure provides critical insights into the molecular interactions between CTNNBL1 and its protein partners, especially AID.

-	~~==Function==~~	+	The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family.,Huang X, Wang G, Wu Y, Du Z Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1598-608. doi:, 10.1107/S0907444913011360. Epub 2013 Jul 20. PMID:23897482<ref>PMID:23897482</ref>
-	~~[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component~~ of ~~the PRP19~~-~~CDC5L complex that forms an integral part~~ of the ~~spliceosome and is required for activating pre~~-~~mRNA splicing~~. ~~Participates in AID/AICDA-mediated Ig class switching recombination~~ (~~CSR~~). ~~May induce apoptosis~~.~~<ref>~~PMID:~~12659813</ref>~~ <ref>PMID:~~18722174~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hnm]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023897482</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Du, Z.]]	+	[[Category: Du, Z]]
-	[[Category: Huang, X.]]	+	[[Category: Huang, X]]
-	[[Category: Wang, G.]]	+	[[Category: Wang, G]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: All alpha-helical]]		[[Category: All alpha-helical]]
	[[Category: Armadillo repeat]]		[[Category: Armadillo repeat]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 08:28, 21 August 2013

OCA — Wed, 21 Aug 2013 08:28:01 GMT

←Older revision		Revision as of 08:28, 21 August 2013
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	{{STRUCTURE_4hnm\| PDB=4hnm \| SCENE= }}		{{STRUCTURE_4hnm\| PDB=4hnm \| SCENE= }}
	===Crystal structure of human catenin-beta-like 1 56 kDa fragment===		===Crystal structure of human catenin-beta-like 1 56 kDa fragment===
		+	{{ABSTRACT_PUBMED_23897482}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023897482</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Du, Z.]]		[[Category: Du, Z.]]

OCA at 05:18, 1 August 2013

OCA — Thu, 01 Aug 2013 05:18:10 GMT

←Older revision		Revision as of 05:18, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hnm\| PDB=4hnm \| SCENE= }}
		+	===Crystal structure of human catenin-beta-like 1 56 kDa fragment===

-	~~The entry 4hnm~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>

-	~~Authors~~: ~~Du, Z~~.~~, Huang, X~~.~~, Wang, G~~.~~, Wu, Y~~.	+	==About this Structure==
		+	[[4hnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNM OCA].

-	~~Description~~: ~~Crystal structure of human catenin~~-~~beta-like 1 56 kDa fragment~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Du, Z.]]
		+	[[Category: Huang, X.]]
		+	[[Category: Wang, G.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: All alpha-helical]]
		+	[[Category: Armadillo repeat]]
		+	[[Category: Protein transport]]

OCA at 11:09, 19 June 2013

OCA — Wed, 19 Jun 2013 11:09:30 GMT

←Older revision		Revision as of 11:09, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hnm is ON HOLD ~~until Paper Publication~~	+	The entry 4hnm is ON HOLD

	Authors: Du, Z., Huang, X., Wang, G., Wu, Y.		Authors: Du, Z., Huang, X., Wang, G., Wu, Y.

	Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment		Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment

OCA at 10:48, 24 April 2013

OCA — Wed, 24 Apr 2013 10:48:20 GMT

←Older revision		Revision as of 10:48, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hnm is ON HOLD	+	The entry 4hnm is ON HOLD until Paper Publication

	Authors: Du, Z., Huang, X., Wang, G., Wu, Y.		Authors: Du, Z., Huang, X., Wang, G., Wu, Y.

	Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment		Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment

OCA at 19:47, 17 April 2013

OCA — Wed, 17 Apr 2013 19:47:47 GMT

←Older revision		Revision as of 19:47, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hnm is ON HOLD ~~until Paper Publication~~	+	The entry 4hnm is ON HOLD

	Authors: Du, Z., Huang, X., Wang, G., Wu, Y.		Authors: Du, Z., Huang, X., Wang, G., Wu, Y.

	Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment		Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment

OCA at 08:49, 2 January 2013

OCA — Wed, 02 Jan 2013 08:49:41 GMT

←Older revision		Revision as of 08:49, 2 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hnm is ON HOLD	+	The entry 4hnm is ON HOLD until Paper Publication

	Authors: Du, Z., Huang, X., Wang, G., Wu, Y.		Authors: Du, Z., Huang, X., Wang, G., Wu, Y.

	Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment		Description: Crystal structure of human catenin-beta-like 1 56 kDa fragment