4hq0 - Revision history

OCA at 08:52, 20 March 2024

OCA — Wed, 20 Mar 2024 08:52:14 GMT

←Older revision		Revision as of 08:52, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [https://pdbe.org/4hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [https://pdbe.org/4hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.		[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Caspase-7 is expressed as a proenzyme and is activated by initiator caspases upon the transmission of cell-death signals. Despite extensive structural and biochemical analyses, many questions regarding the mechanism of caspase-7 activation remain unanswered. Caspase-7 is auto-activated during overexpression in Escherichia coli, even in the absence of initiator caspases, indicating that procaspase-7 has intrinsic catalytic activity. When variants of procaspase-7 with altered L2 loops were prepared, a variant with six inserted amino acids showed meaningful catalytic activity which was inhibited by Ac-DEVD-CHO. The kinetic constants of the procaspase-7 variant were determined and its three-dimensional structure was solved with and without bound inhibitor. The homodimeric procaspase-7 bound to the inhibitor revealed an asymmetry. One monomer formed a complete active site bound to the inhibitor in collaboration with the L2 loop from the other monomer, whereas the other monomer had an incomplete active site despite the bound inhibitor. Consequently, the two L2 loops in homodimeric procaspase-7 served as inherent L2 and L2' loops forming one complete active site. These data represent the first three-dimensional structure of a procaspase-7 variant bound to a specific inhibitor, Ac-DEVD-CHO, and provide insight into the folding mechanism during caspase-7 activation and the basal activity level of procaspase-7.
-
-	Structural asymmetry of procaspase-7 bound to a specific inhibitor.,Kang HJ, Lee YM, Bae KH, Kim SJ, Chung SJ Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1514-21. doi:, 10.1107/S0907444913010196. Epub 2013 Jul 18. PMID:23897474<ref>PMID:23897474</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hq0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Caspase 3D structures\|Caspase 3D structures]]		*[[Caspase 3D structures\|Caspase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 9 November 2022

OCA — Wed, 09 Nov 2022 08:04:05 GMT

←Older revision		Revision as of 08:04, 9 November 2022
Line 1:		Line 1:

	==Crystal Structure of mutant form of Caspase-7==		==Crystal Structure of mutant form of Caspase-7==
-	<StructureSection load='4hq0' size='340' side='right' caption='[[4hq0]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4hq0' size='340' side='right'caption='[[4hq0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k86\|1k86]], [[4hqr\|4hqr]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [https://pdbe.org/4hq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [~~http~~://pdbe.org/4hq0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-7~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Bae, K H]]	+	[[Category: Bae K-H]]
-	[[Category: Chung~~, S J~~]]	+	[[Category: Chung SJ]]
-	[[Category: Kang~~, H J~~]]	+	[[Category: Kang HJ]]
-	[[Category: Kim~~, S J~~]]	+	[[Category: Kim SJ]]
-	[[Category: Lee, Y]]	+	[[Category: Lee Y]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 15:17, 5 August 2016

OCA — Fri, 05 Aug 2016 15:17:54 GMT

←Older revision		Revision as of 15:17, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of mutant form of Caspase-7==		==Crystal Structure of mutant form of Caspase-7==
	<StructureSection load='4hq0' size='340' side='right' caption='[[4hq0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4hq0' size='340' side='right' caption='[[4hq0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k86\|1k86]], [[4hqr\|4hqr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k86\|1k86]], [[4hqr\|4hqr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hq0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [http://pdbe.org/4hq0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hq0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hq0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hq0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bae, K H]]		[[Category: Bae, K H]]
	[[Category: Chung, S J]]		[[Category: Chung, S J]]

OCA at 03:33, 25 December 2014

OCA — Thu, 25 Dec 2014 03:33:24 GMT

←Older revision		Revision as of 03:33, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hq0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hq0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:01, 21 December 2014

OCA — Sun, 21 Dec 2014 13:01:27 GMT

←Older revision		Revision as of 13:01, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hq0~~\| ~~PDB~~=4hq0 \| ~~SCENE~~= }}	+	==Crystal Structure of mutant form of Caspase-7==
-	===~~Crystal Structure of mutant form of~~ Caspase-7===	+	<StructureSection load='4hq0' size='340' side='right' caption='[[4hq0]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23897474}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQ0 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k86\|1k86]], [[4hqr\|4hqr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hq0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hq0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hq0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Caspase-7 is expressed as a proenzyme and is activated by initiator caspases upon the transmission of cell-death signals. Despite extensive structural and biochemical analyses, many questions regarding the mechanism of caspase-7 activation remain unanswered. Caspase-7 is auto-activated during overexpression in Escherichia coli, even in the absence of initiator caspases, indicating that procaspase-7 has intrinsic catalytic activity. When variants of procaspase-7 with altered L2 loops were prepared, a variant with six inserted amino acids showed meaningful catalytic activity which was inhibited by Ac-DEVD-CHO. The kinetic constants of the procaspase-7 variant were determined and its three-dimensional structure was solved with and without bound inhibitor. The homodimeric procaspase-7 bound to the inhibitor revealed an asymmetry. One monomer formed a complete active site bound to the inhibitor in collaboration with the L2 loop from the other monomer, whereas the other monomer had an incomplete active site despite the bound inhibitor. Consequently, the two L2 loops in homodimeric procaspase-7 served as inherent L2 and L2' loops forming one complete active site. These data represent the first three-dimensional structure of a procaspase-7 variant bound to a specific inhibitor, Ac-DEVD-CHO, and provide insight into the folding mechanism during caspase-7 activation and the basal activity level of procaspase-7.

-	~~==Function==~~	+	Structural asymmetry of procaspase-7 bound to a specific inhibitor.,Kang HJ, Lee YM, Bae KH, Kim SJ, Chung SJ Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1514-21. doi:, 10.1107/S0907444913010196. Epub 2013 Jul 18. PMID:23897474<ref>PMID:23897474</ref>
-	~~[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade~~ of ~~caspases responsible for apoptosis execution~~. ~~Cleaves and activates sterol regulatory element binding proteins (SREBPs)~~. ~~Proteolytically cleaves poly~~(~~ADP-ribose~~) ~~polymerase (PARP) at a '216~~-~~Asp-\|-Gly-217' bond~~. ~~Overexpression promotes programmed cell death~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hq0]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023897474</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Caspase\|Caspase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bae, K H.]]	+	[[Category: Bae, K H]]
-	[[Category: Chung, S J.]]	+	[[Category: Chung, S J]]
-	[[Category: Kang, H J.]]	+	[[Category: Kang, H J]]
-	[[Category: Kim, S J.]]	+	[[Category: Kim, S J]]
-	[[Category: Lee, Y.]]	+	[[Category: Lee, Y]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:18, 12 September 2013

OCA — Thu, 12 Sep 2013 05:18:01 GMT

←Older revision		Revision as of 05:18, 12 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hq0\| PDB=4hq0 \| SCENE= }}
		+	===Crystal Structure of mutant form of Caspase-7===
		+	{{ABSTRACT_PUBMED_23897474}}

-	~~The entry 4hq0 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.

-	~~Authors~~: ~~Lee, Y~~.~~, Kang, H~~.J.~~, Bae, K~~.-H.~~, Kim, S~~.~~J., Chung, S.J~~.	+	==About this Structure==
		+	[[4hq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA].

-	~~Description~~: ~~Crystal Structure of mutant form of~~ Caspase-7	+	==Reference==
		+	<ref group="xtra">PMID:023897474</ref><references group="xtra"/><references/>
		+	[[Category: Caspase-7]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Bae, K H.]]
		+	[[Category: Chung, S J.]]
		+	[[Category: Kang, H J.]]
		+	[[Category: Kim, S J.]]
		+	[[Category: Lee, Y.]]
		+	[[Category: Hydrolase]]

OCA at 13:42, 6 March 2013

OCA — Wed, 06 Mar 2013 13:42:46 GMT

←Older revision		Revision as of 13:42, 6 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hq0 is ON HOLD	+	The entry 4hq0 is ON HOLD until Paper Publication

	Authors: Lee, Y., Kang, H.J., Bae, K.-H., Kim, S.J., Chung, S.J.		Authors: Lee, Y., Kang, H.J., Bae, K.-H., Kim, S.J., Chung, S.J.

	Description: Crystal Structure of mutant form of Caspase-7		Description: Crystal Structure of mutant form of Caspase-7

OCA at 09:05, 21 November 2012

OCA — Wed, 21 Nov 2012 09:05:43 GMT

←Older revision		Revision as of 09:05, 21 November 2012
Line 3:		Line 3:
	The entry 4hq0 is ON HOLD		The entry 4hq0 is ON HOLD

-	Authors: ~~Young-mi,~~ Lee, ~~Hyo Jin~~, Kang, ~~Kwang-Hee~~, Bae, ~~Seung Jun~~, Kim, ~~Sang~~ J., Chung	+	Authors: Lee, Y., Kang, H.J., Bae, K.-H., Kim, S.J., Chung, S.J.

-	Description: Crystal Structure of mutant form of Caspase-7 ~~(CASP Target)~~	+	Description: Crystal Structure of mutant form of Caspase-7

OCA: Protected "4hq0" [edit=sysop:move=sysop]

OCA — Wed, 31 Oct 2012 08:44:02 GMT

Protected "4hq0" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 31 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hq0 is ON HOLD Authors: Young-mi, Lee, Hyo Jin, Kang, Kwang-Hee, Bae, Seung Jun, Kim, Sang J., Chung Description: Crystal Structure of mutant form...

OCA — Wed, 31 Oct 2012 08:44:01 GMT

New page: '''Unreleased structure''' The entry 4hq0 is ON HOLD Authors: Young-mi, Lee, Hyo Jin, Kang, Kwang-Hee, Bae, Seung Jun, Kim, Sang J., Chung Description: Crystal Structure of mutant form...

New page

'''Unreleased structure'''

The entry 4hq0 is ON HOLD

Authors: Young-mi, Lee, Hyo Jin, Kang, Kwang-Hee, Bae, Seung Jun, Kim, Sang J., Chung

Description: Crystal Structure of mutant form of Caspase-7 (CASP Target)