4hqf - Revision history

OCA at 15:09, 20 September 2023

OCA — Wed, 20 Sep 2023 15:09:44 GMT

←Older revision		Revision as of 15:09, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [https://pdbe.org/4hqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [https://www.ebi.ac.uk/pdbsum/4hqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [https://pdbe.org/4hqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [https://www.ebi.ac.uk/pdbsum/4hqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:04, 9 November 2022

OCA — Wed, 09 Nov 2022 08:04:43 GMT

←Older revision		Revision as of 08:04, 9 November 2022
Line 1:		Line 1:

	==Crystal structure of Plasmodium falciparum TRAP, I4 form==		==Crystal structure of Plasmodium falciparum TRAP, I4 form==
-	<StructureSection load='4hqf' size='340' side='right' caption='[[4hqf]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4hqf' size='340' side='right'caption='[[4hqf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqk\|4hqk]], [[4hql\|4hql]], [[4hqn\|4hqn]], [[4hqo\|4hqo]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [https://pdbe.org/4hqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [https://www.ebi.ac.uk/pdbsum/4hqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqf ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP, PF13_0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [~~http~~://pdbe.org/4hqf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hqf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q76NM2_PLAF7 Q76NM2_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plaf7~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Koksal, A C~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: ~~Lu, C~~]]	+	[[Category: Koksal AC]]
-	[[Category: ~~Song, G~~]]	+	[[Category: Lu C]]
-	[[Category: ~~Springer, T A~~]]	+	[[Category: Song G]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Springer TA]]
-	~~[[Category: I domain]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Parasite motility]]~~	+
-	~~[[Category: Receptor on sporozoite]]~~	+
-	~~[[Category: Sporozoite surface]]~~	+
-	~~[[Category: Tsr domain]]~~	+
-	~~[[Category: Vaccine target~~]]	+

OCA at 19:48, 15 December 2016

OCA — Thu, 15 Dec 2016 19:48:55 GMT

←Older revision		Revision as of 19:48, 15 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of Plasmodium falciparum TRAP, I4 form==		==Crystal structure of Plasmodium falciparum TRAP, I4 form==
	<StructureSection load='4hqf' size='340' side='right' caption='[[4hqf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4hqf' size='340' side='right' caption='[[4hqf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqk\|4hqk]], [[4hql\|4hql]], [[4hqn\|4hqn]], [[4hqo\|4hqo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqk\|4hqk]], [[4hql\|4hql]], [[4hqn\|4hqn]], [[4hqo\|4hqo]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP, PF13_0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 ~~Plasmodium falciparum 3D7~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP, PF13_0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [http://www.ebi.ac.uk/pdbsum/4hqf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [http://pdbe.org/4hqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [http://www.ebi.ac.uk/pdbsum/4hqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hqf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum 3d7~~]]	+	[[Category: Plaf7]]
	[[Category: Koksal, A C]]		[[Category: Koksal, A C]]
	[[Category: Lu, C]]		[[Category: Lu, C]]

OCA at 09:04, 10 December 2014

OCA — Wed, 10 Dec 2014 09:04:44 GMT

←Older revision		Revision as of 09:04, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hqf.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Plasmodium falciparum TRAP, I4 form==
		+	<StructureSection load='4hqf' size='340' side='right' caption='[[4hqf]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HQF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hqk\|4hqk]], [[4hql\|4hql]], [[4hqn\|4hqn]], [[4hqo\|4hqo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP, PF13_0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hqf RCSB], [http://www.ebi.ac.uk/pdbsum/4hqf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sporozoite gliding motility and invasion of mosquito and vertebrate host cells in malaria is mediated by thrombospondin repeat anonymous protein (TRAP). Tandem von Willebrand factor A (VWA) and thrombospondin type I repeat (TSR) domains in TRAP connect through proline-rich stalk, transmembrane, and cytoplasmic domains to the parasite actin-dependent motility apparatus. We crystallized fragments containing the VWA and TSR domains from Plasmodium vivax and Plasmodium falciparum in different crystal lattices. TRAP VWA domains adopt closed and open conformations, and bind a Mg(2+) ion at a metal ion-dependent adhesion site implicated in ligand binding. Metal ion coordination in the open state is identical to that seen in the open high-affinity state of integrin I domains. The closed VWA conformation associates with a disordered TSR domain. In contrast, the open VWA conformation crystallizes with an extensible beta ribbon and ordered TSR domain. The extensible beta ribbon is composed of disulfide-bonded segments N- and C-terminal to the VWA domain that are largely drawn out of the closed VWA domain in a 15 A movement to the open conformation. The extensible beta ribbon and TSR domain overlap at a conserved interface. The VWA, extensible beta ribbon, and TSR domains adopt a highly elongated overall orientation that would be stabilized by tensile force exerted across a ligand-receptor complex by the actin motility apparatus of the sporozoite. Our results provide insights into regulation of "stick-and-slip" parasite motility and for development of sporozoite subunit vaccines.

-	~~{{STRUCTURE_4hqf\| PDB=4hqf \| SCENE= }}~~	+	Shape change in the receptor for gliding motility in Plasmodium sporozoites.,Song G, Koksal AC, Lu C, Springer TA Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21420-5. doi:, 10.1073/pnas.1218581109. Epub 2012 Dec 11. PMID:23236185<ref>PMID:23236185</ref>

-	~~===Crystal structure~~ of ~~Plasmodium falciparum TRAP, I4 form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23236185}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hqf]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA].~~	+	</StructureSection>
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
-	[[Category: Koksal, A C.]]	+	[[Category: Koksal, A C]]
-	[[Category: Lu, C.]]	+	[[Category: Lu, C]]
-	[[Category: Song, G.]]	+	[[Category: Song, G]]
-	[[Category: Springer, T A.]]	+	[[Category: Springer, T A]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: I domain]]		[[Category: I domain]]

OCA at 08:32, 9 January 2013

OCA — Wed, 09 Jan 2013 08:32:15 GMT

←Older revision		Revision as of 08:32, 9 January 2013
Line 1:		Line 1:
-	[[Image:4hqf.~~jpg~~\|left\|200px]]	+	[[Image:4hqf.png\|left\|200px]]

	{{STRUCTURE_4hqf\| PDB=4hqf \| SCENE= }}		{{STRUCTURE_4hqf\| PDB=4hqf \| SCENE= }}

OCA at 09:17, 2 January 2013

OCA — Wed, 02 Jan 2013 09:17:08 GMT

←Older revision		Revision as of 09:17, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hqf.jpg\|left\|200px]]

-	~~The entry~~ 4hqf ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hqf\| PDB=4hqf \| SCENE= }}

-	~~Authors: Song~~, ~~G., Koksal, A.C., Lu, C., Springer, T.A.~~	+	===Crystal structure of Plasmodium falciparum TRAP, I4 form===

-	~~Description: Crystal~~ structure of Plasmodium falciparum ~~TRAP~~, ~~I4 form~~	+	{{ABSTRACT_PUBMED_23236185}}
		+
		+	==About this Structure==
		+	[[4hqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQF OCA].
		+	[[Category: Plasmodium falciparum 3d7]]
		+	[[Category: Koksal, A C.]]
		+	[[Category: Lu, C.]]
		+	[[Category: Song, G.]]
		+	[[Category: Springer, T A.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: I domain]]
		+	[[Category: Malaria]]
		+	[[Category: Parasite motility]]
		+	[[Category: Receptor on sporozoite]]
		+	[[Category: Sporozoite surface]]
		+	[[Category: Tsr domain]]
		+	[[Category: Vaccine target]]

OCA at 09:06, 21 November 2012

OCA — Wed, 21 Nov 2012 09:06:00 GMT

←Older revision		Revision as of 09:06, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hqf is ON HOLD	+	The entry 4hqf is ON HOLD until Paper Publication

	Authors: Song, G., Koksal, A.C., Lu, C., Springer, T.A.		Authors: Song, G., Koksal, A.C., Lu, C., Springer, T.A.

	Description: Crystal structure of Plasmodium falciparum TRAP, I4 form		Description: Crystal structure of Plasmodium falciparum TRAP, I4 form

OCA at 06:17, 14 November 2012

OCA — Wed, 14 Nov 2012 06:17:10 GMT

←Older revision		Revision as of 06:17, 14 November 2012
Line 3:		Line 3:
	The entry 4hqf is ON HOLD		The entry 4hqf is ON HOLD

-	Authors: Song, G. , Koksal, A.C., Lu, C., Springer, T. A.	+	Authors: Song, G., Koksal, A.C., Lu, C., Springer, T.A.

-	Description: ~~crystal~~ structure of ~~plasmodium~~ falciparum TRAP, I4 form	+	Description: Crystal structure of Plasmodium falciparum TRAP, I4 form

OCA: Protected "4hqf" [edit=sysop:move=sysop]

OCA — Wed, 31 Oct 2012 08:44:29 GMT

Protected "4hqf" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 31 October 2012

OCA: New page: '''Unreleased structure''' The entry 4hqf is ON HOLD Authors: Song, G. , Koksal, A.C., Lu, C., Springer, T. A. Description: crystal structure of plasmodium falciparum TRAP, I4 form

OCA — Wed, 31 Oct 2012 08:44:28 GMT

New page: '''Unreleased structure''' The entry 4hqf is ON HOLD Authors: Song, G. , Koksal, A.C., Lu, C., Springer, T. A. Description: crystal structure of plasmodium falciparum TRAP, I4 form

New page

'''Unreleased structure'''

The entry 4hqf is ON HOLD

Authors: Song, G. , Koksal, A.C., Lu, C., Springer, T. A.

Description: crystal structure of plasmodium falciparum TRAP, I4 form