4hu9 - Revision history

OCA at 08:15, 9 November 2022

OCA — Wed, 09 Nov 2022 08:15:14 GMT

←Older revision		Revision as of 08:15, 9 November 2022
Line 1:		Line 1:

	==E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue==		==E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue==
-	<StructureSection load='4hu9' size='340' side='right' caption='[[4hu9]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4hu9' size='340' side='right'caption='[[4hu9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hu9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HU9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hu9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HU9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4FB:(4S)-4-FLUORO-L-PROLINE'>4FB</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=4FB:(4S)-4-FLUORO-L-PROLINE'>4FB</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [https://pdbe.org/4hu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [https://www.ebi.ac.uk/pdbsum/4hu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hu9 ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4hu7\|4hu7]], [[4hua\|4hua]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [~~http~~://pdbe.org/4hu9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hu9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hu9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.	+	[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hu9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hu9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thioredoxin 3D structures\|Thioredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Capitani, G~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Glockshuber, R~~]]	+	[[Category: Capitani G]]
-	[[Category: ~~Rubini, M~~]]	+	[[Category: Glockshuber R]]
-	[[Category: ~~Scharer,~~ M A]]	+	[[Category: Rubini M]]
-	[[Category: ~~4s-fluoroproline]]~~	+	[[Category: Scharer MA]]
-	~~[[Category: Cisproline]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein disulfide oxidoreductase activity]]~~	+
-	~~[[Category: Thioredoxin fold~~]]	+

OCA at 14:39, 15 November 2017

OCA — Wed, 15 Nov 2017 14:39:32 GMT

←Older revision		Revision as of 14:39, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4hu9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hu9" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Thioredoxin\|Thioredoxin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:35, 5 August 2016

OCA — Fri, 05 Aug 2016 15:35:23 GMT

←Older revision		Revision as of 15:35, 5 August 2016
Line 1:		Line 1:
		+
	==E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue==		==E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue==
	<StructureSection load='4hu9' size='340' side='right' caption='[[4hu9]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4hu9' size='340' side='right' caption='[[4hu9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HU9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HU9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FB:(4S)-4-FLUORO-L-PROLINE'>4FB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FB:(4S)-4-FLUORO-L-PROLINE'>4FB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hu7\|4hu7]], [[4hua\|4hua]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hu7\|4hu7]], [[4hua\|4hua]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hu9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [http://pdbe.org/4hu9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hu9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hu9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hu9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Capitani, G]]		[[Category: Capitani, G]]
	[[Category: Glockshuber, R]]		[[Category: Glockshuber, R]]

OCA at 03:38, 25 December 2014

OCA — Thu, 25 Dec 2014 03:38:35 GMT

←Older revision		Revision as of 03:38, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hu9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hu9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:11, 21 December 2014

OCA — Sun, 21 Dec 2014 13:11:16 GMT

←Older revision		Revision as of 13:11, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hu9\| PDB=4hu9 \| SCENE= }}~~	+	==E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue==
-	===E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue===	+	<StructureSection load='4hu9' size='340' side='right' caption='[[4hu9]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23712956}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HU9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FB:(4S)-4-FLUORO-L-PROLINE'>4FB</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hu7\|4hu7]], [[4hua\|4hua]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4hu9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fine-tuning protein stability: The non-natural amino acids (2S,4R)- and (2S,4S)-fluoroproline modulate protein stability by biasing the proline ring pucker and the cis/trans equilibrium of prolyl peptide bonds. We incorporated both fluoroproline stereoisomers at the invariant cis-proline residue of the thioredoxin fold. The results show that tertiary structure context overrules the conformational preferences of fluoroprolines.

-	~~==Function==~~	+	(4R)- and (4S)-Fluoroproline in the Conserved cis-Prolyl Peptide Bond of the Thioredoxin Fold: Tertiary Structure Context Dictates Ring Puckering.,Rubini M, Scharer MA, Capitani G, Glockshuber R Chembiochem. 2013 Jun 17;14(9):1053-7. doi: 10.1002/cbic.201300178. Epub 2013 May, 27. PMID:23712956<ref>PMID:23712956</ref>
-	~~[[http://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates~~ in ~~various redox reactions through~~ the ~~reversible oxidation~~ of ~~its active center dithiol to a disulfide and catalyzes dithiol~~-~~disulfide exchange reactions~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hu9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023712956</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Thioredoxin\|Thioredoxin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
-	[[Category: Capitani, G.]]	+	[[Category: Capitani, G]]
-	[[Category: Glockshuber, R.]]	+	[[Category: Glockshuber, R]]
-	[[Category: Rubini, M.]]	+	[[Category: Rubini, M]]
-	[[Category: Scharer, M A.]]	+	[[Category: Scharer, M A]]
	[[Category: 4s-fluoroproline]]		[[Category: 4s-fluoroproline]]
	[[Category: Cisproline]]		[[Category: Cisproline]]

OCA at 12:39, 3 July 2013

OCA — Wed, 03 Jul 2013 12:39:28 GMT

←Older revision		Revision as of 12:39, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4hu9\| PDB=4hu9 \| SCENE= }}		{{STRUCTURE_4hu9\| PDB=4hu9 \| SCENE= }}
	===E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue===		===E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue===
		+	{{ABSTRACT_PUBMED_23712956}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA].		[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023712956</ref><references group="xtra"/><references/>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Capitani, G.]]		[[Category: Capitani, G.]]

OCA at 16:20, 19 June 2013

OCA — Wed, 19 Jun 2013 16:20:35 GMT

←Older revision		Revision as of 16:20, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hu9\| PDB=4hu9 \| SCENE= }}
		+	===E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue===

-	~~The entry 4hu9 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

-	~~Authors~~: ~~Scharer, M~~.A.~~, Rubini, M~~., Capitani, G., Glockshuber, R.	+	==About this Structure==
-		+	[[4hu9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU9 OCA].
-	~~Description~~: E. ~~coli thioredoxin variant with (4S)~~-~~FluoroPro76 as single proline residue~~	+	[[Category: Escherichia coli k-12]]
		+	[[Category: Capitani, G.]]
		+	[[Category: Glockshuber, R.]]
		+	[[Category: Rubini, M.]]
		+	[[Category: Scharer, M A.]]
		+	[[Category: 4s-fluoroproline]]
		+	[[Category: Cisproline]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein disulfide oxidoreductase activity]]
		+	[[Category: Thioredoxin fold]]

OCA at 13:21, 20 February 2013

OCA — Wed, 20 Feb 2013 13:21:21 GMT

←Older revision		Revision as of 13:21, 20 February 2013
Line 3:		Line 3:
	The entry 4hu9 is ON HOLD until Paper Publication		The entry 4hu9 is ON HOLD until Paper Publication

-	Authors: Scharer, M.A., Rubini, M., Glockshuber, R.	+	Authors: Scharer, M.A., Rubini, M., Capitani, G., Glockshuber, R.

	Description: E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue		Description: E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue

OCA at 09:07, 21 November 2012

OCA — Wed, 21 Nov 2012 09:07:16 GMT

←Older revision		Revision as of 09:07, 21 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hu9 is ON HOLD	+	The entry 4hu9 is ON HOLD until Paper Publication

-	Authors: Scharer, M.A., Rubini, M., Glockshuber, M.	+	Authors: Scharer, M.A., Rubini, M., Glockshuber, R.

	Description: E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue		Description: E. coli thioredoxin variant with (4S)-FluoroPro76 as single proline residue

OCA: Protected "4hu9" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:18:53 GMT

Protected "4hu9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 14 November 2012