4hum - Revision history

OCA at 11:44, 1 March 2024

OCA — Fri, 01 Mar 2024 11:44:52 GMT

←Older revision		Revision as of 11:44, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_TCDC-NG08107 Neisseria gonorrhoeae TCDC-NG08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_TCDC-NG08107 Neisseria gonorrhoeae TCDC-NG08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [https://pdbe.org/4hum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [https://www.ebi.ac.uk/pdbsum/4hum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hum ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [https://pdbe.org/4hum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [https://www.ebi.ac.uk/pdbsum/4hum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hum ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/M1E1G6_ECOLX M1E1G6_ECOLX]		[https://www.uniprot.org/uniprot/M1E1G6_ECOLX M1E1G6_ECOLX]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na(+) or H(+) gradient. Despite its clinical relevance, the transport mechanism of MATE proteins remains poorly understood, largely owing to a lack of structural information on the substrate-bound transporter. Here we report crystal structures of a Na(+)-coupled MATE transporter NorM from Neisseria gonorrheae in complexes with three distinct translocation substrates (ethidium, rhodamine 6G, and tetraphenylphosphonium), as well as Cs(+) (a Na(+) congener), all captured in extracellular-facing and drug-bound states. The structures revealed a multidrug-binding cavity festooned with four negatively charged amino acids and surprisingly limited hydrophobic moieties, in stark contrast to the general belief that aromatic amino acids play a prominent role in multidrug recognition. Furthermore, we discovered an uncommon cation-pi interaction in the Na(+)-binding site located outside the drug-binding cavity and validated the biological relevance of both the substrate- and cation-binding sites by conducting drug resistance and transport assays. Additionally, we uncovered potential rearrangement of at least two transmembrane helices upon Na(+)-induced drug export. Based on our structural and functional analyses, we suggest that Na(+) triggers multidrug extrusion by inducing protein conformational changes rather than by directly competing for the substrate-binding amino acids. This scenario is distinct from the canonical antiport mechanism, in which both substrate and counterion compete for a shared binding site in the transporter. Collectively, our findings provide an important step toward a detailed and mechanistic understanding of multidrug transport.
-
-	Structures of a Na+-coupled, substrate-bound MATE multidrug transporter.,Lu M, Symersky J, Radchenko M, Koide A, Guo Y, Nie R, Koide S Proc Natl Acad Sci U S A. 2013 Jan 22. PMID:23341609<ref>PMID:23341609</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hum" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:16, 9 November 2022

OCA — Wed, 09 Nov 2022 08:16:34 GMT

←Older revision		Revision as of 08:16, 9 November 2022
Line 1:		Line 1:

	==MATE transporter NorM-NG in complex with ethidium and monobody==		==MATE transporter NorM-NG in complex with ethidium and monobody==
-	<StructureSection load='4hum' size='340' side='right' caption='[[4hum]], [[Resolution\|resolution]] 3.49Å' scene=''>	+	<StructureSection load='4hum' size='340' side='right'caption='[[4hum]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~] and [~~http~~://en.wikipedia.org/wiki/~~Neisseria_gonorrhoeae_tcdc~~-~~ng08107~~ Neisseria gonorrhoeae ~~tcdc~~-~~ng08107~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HUM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_TCDC-NG08107 Neisseria gonorrhoeae TCDC-NG08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4huk\|4huk]], [[4hul\|4hul]], [[4hun\|4hun]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [https://pdbe.org/4hum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [https://www.ebi.ac.uk/pdbsum/4hum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hum ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NGTW08_0430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=940296 Neisseria gonorrhoeae TCDC-NG08107])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [~~http~~://pdbe.org/4hum PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hum PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hum ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M1E1G6_ECOLX M1E1G6_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
-	[[Category: ~~Neisseria gonorrhoeae tcdc-ng08107~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lu, M~~]]	+	[[Category: Neisseria gonorrhoeae TCDC-NG08107]]
-	[[Category: ~~Transport protein~~]]	+	[[Category: Lu M]]

OCA at 07:21, 23 December 2016

OCA — Fri, 23 Dec 2016 07:21:50 GMT

←Older revision		Revision as of 07:21, 23 December 2016
Line 1:		Line 1:
		+
	==MATE transporter NorM-NG in complex with ethidium and monobody==		==MATE transporter NorM-NG in complex with ethidium and monobody==
	<StructureSection load='4hum' size='340' side='right' caption='[[4hum]], [[Resolution\|resolution]] 3.49Å' scene=''>		<StructureSection load='4hum' size='340' side='right' caption='[[4hum]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli] and [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_tcdc-ng08107 Neisseria gonorrhoeae tcdc-ng08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_tcdc-ng08107 Neisseria gonorrhoeae tcdc-ng08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4huk\|4huk]], [[4hul\|4hul]], [[4hun\|4hun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4huk\|4huk]], [[4hul\|4hul]], [[4hun\|4hun]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NGTW08_0430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=940296 Neisseria gonorrhoeae TCDC-NG08107])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NGTW08_0430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=940296 Neisseria gonorrhoeae TCDC-NG08107])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [http://www.ebi.ac.uk/pdbsum/4hum PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [http://pdbe.org/4hum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [http://www.ebi.ac.uk/pdbsum/4hum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hum ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hum" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Neisseria gonorrhoeae tcdc-ng08107]]		[[Category: Neisseria gonorrhoeae tcdc-ng08107]]
	[[Category: Lu, M]]		[[Category: Lu, M]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 09:32, 10 December 2014

OCA — Wed, 10 Dec 2014 09:32:49 GMT

←Older revision		Revision as of 09:32, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hum.~~png~~\|~~left~~\|~~200px~~]]	+	==MATE transporter NorM-NG in complex with ethidium and monobody==
		+	<StructureSection load='4hum' size='340' side='right' caption='[[4hum]], [[Resolution\|resolution]] 3.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hum]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_tcdc-ng08107 Neisseria gonorrhoeae tcdc-ng08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4huk\|4huk]], [[4hul\|4hul]], [[4hun\|4hun]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NGTW08_0430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=940296 Neisseria gonorrhoeae TCDC-NG08107])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hum RCSB], [http://www.ebi.ac.uk/pdbsum/4hum PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na(+) or H(+) gradient. Despite its clinical relevance, the transport mechanism of MATE proteins remains poorly understood, largely owing to a lack of structural information on the substrate-bound transporter. Here we report crystal structures of a Na(+)-coupled MATE transporter NorM from Neisseria gonorrheae in complexes with three distinct translocation substrates (ethidium, rhodamine 6G, and tetraphenylphosphonium), as well as Cs(+) (a Na(+) congener), all captured in extracellular-facing and drug-bound states. The structures revealed a multidrug-binding cavity festooned with four negatively charged amino acids and surprisingly limited hydrophobic moieties, in stark contrast to the general belief that aromatic amino acids play a prominent role in multidrug recognition. Furthermore, we discovered an uncommon cation-pi interaction in the Na(+)-binding site located outside the drug-binding cavity and validated the biological relevance of both the substrate- and cation-binding sites by conducting drug resistance and transport assays. Additionally, we uncovered potential rearrangement of at least two transmembrane helices upon Na(+)-induced drug export. Based on our structural and functional analyses, we suggest that Na(+) triggers multidrug extrusion by inducing protein conformational changes rather than by directly competing for the substrate-binding amino acids. This scenario is distinct from the canonical antiport mechanism, in which both substrate and counterion compete for a shared binding site in the transporter. Collectively, our findings provide an important step toward a detailed and mechanistic understanding of multidrug transport.

-	~~{{STRUCTURE_4hum\| PDB=4hum \| SCENE= }}~~	+	Structures of a Na+-coupled, substrate-bound MATE multidrug transporter.,Lu M, Symersky J, Radchenko M, Koide A, Guo Y, Nie R, Koide S Proc Natl Acad Sci U S A. 2013 Jan 22. PMID:23341609<ref>PMID:23341609</ref>

-	~~===MATE transporter NorM-NG in complex with ethidium and monobody===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23341609}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hum]] is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_tcdc-ng08107 Neisseria gonorrhoeae tcdc-ng08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA].	+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Neisseria gonorrhoeae tcdc-ng08107]]		[[Category: Neisseria gonorrhoeae tcdc-ng08107]]
-	[[Category: Lu, M.]]	+	[[Category: Lu, M]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 13:00, 6 March 2013

OCA — Wed, 06 Mar 2013 13:00:25 GMT

←Older revision		Revision as of 13:00, 6 March 2013
Line 1:		Line 1:
-	[[Image:4hum.~~jpg~~\|left\|200px]]	+	[[Image:4hum.png\|left\|200px]]

	{{STRUCTURE_4hum\| PDB=4hum \| SCENE= }}		{{STRUCTURE_4hum\| PDB=4hum \| SCENE= }}

OCA at 12:48, 6 February 2013

OCA — Wed, 06 Feb 2013 12:48:48 GMT

←Older revision		Revision as of 12:48, 6 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hum.jpg\|left\|200px]]

-	~~The entry~~ 4hum ~~is ON HOLD~~	+	{{STRUCTURE_4hum\| PDB=4hum \| SCENE= }}

-	~~Authors: Lu, M.~~	+	===MATE transporter NorM-NG in complex with ethidium and monobody===

-	~~Description~~: ~~Protein complex 3~~	+	{{ABSTRACT_PUBMED_23341609}}
		+
		+	==About this Structure==
		+	[[4hum]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_tcdc-ng08107 Neisseria gonorrhoeae tcdc-ng08107]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUM OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Neisseria gonorrhoeae tcdc-ng08107]]
		+	[[Category: Lu, M.]]
		+	[[Category: Transport protein]]

OCA: Protected "4hum" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:19:15 GMT

Protected "4hum" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 14 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hum is ON HOLD Authors: Lu, M. Description: Protein complex 3

OCA — Wed, 14 Nov 2012 06:19:14 GMT

New page: '''Unreleased structure''' The entry 4hum is ON HOLD Authors: Lu, M. Description: Protein complex 3

New page

'''Unreleased structure'''

The entry 4hum is ON HOLD

Authors: Lu, M.

Description: Protein complex 3