4hv5 - Revision history

OCA at 11:44, 1 March 2024

OCA — Fri, 01 Mar 2024 11:44:56 GMT

←Older revision		Revision as of 11:44, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [https://pdbe.org/4hv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [https://www.ebi.ac.uk/pdbsum/4hv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hv5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [https://pdbe.org/4hv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [https://www.ebi.ac.uk/pdbsum/4hv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hv5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.		[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The manganese transport regulator (MntR) represses the expression of genes involved in manganese uptake in Bacillus subtilis. It selectively responds to Mn(2+) and Cd(2+) over other divalent metal cations, including Fe(2+), Co(2+), and Zn(2+). Previous work has shown that MntR forms binuclear complexes with Mn(2+) or Cd(2+) at two binding sites, labeled A and C, that are separated by 4.4 A. Zinc activates MntR poorly and binds only to the A site, forming a mononuclear complex. The difference in metal binding stoichiometry suggested a mechanism for selectivity in MntR. Larger metal cations are strongly activating because they can form the binuclear complex, while smaller metal ions cannot bind with the geometry needed to fully occupy both metal binding sites. To investigate this hypothesis, structures of MntR in complex with two other noncognate metal ions, Fe(2+) and Co(2+), have been determined. Each metal forms a mononuclear complex with MntR with the metal ion bound in the A site, supporting the conclusions drawn from the Zn(2+) complex. Additionally, we investigated two site-specific mutants of MntR, E11K and H77A, that contain substitutions of metal binding residues in the A site. While metal binding in each mutant is significantly altered relative to that of wild-type MntR, both mutants retain activity and selectivity for Mn(2+) in vitro and in vivo. That observation, coupled with previous studies, suggests that the A and C sites both contribute to the selectivity of MntR.
-
-	Roles of the A and C Sites in the Manganese-Specific Activation of MntR.,McGuire AM, Cuthbert BJ, Ma Z, Grauer-Gray KD, Brunjes Brophy M, Spear KA, Soonsanga S, Kliegman JI, Griner SL, Helmann JD, Glasfeld A Biochemistry. 2013 Jan 29;52(4):701-13. doi: 10.1021/bi301550t. Epub 2013 Jan 17. PMID:23298157<ref>PMID:23298157</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hv5" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:17, 9 November 2022

OCA — Wed, 09 Nov 2022 08:17:55 GMT

←Older revision		Revision as of 08:17, 9 November 2022
Line 1:		Line 1:

	==Structure of the MNTR FE2+ complex with E site metal binding==		==Structure of the MNTR FE2+ complex with E site metal binding==
-	<StructureSection load='4hv5' size='340' side='right' caption='[[4hv5]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4hv5' size='340' side='right'caption='[[4hv5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5d\|2f5d]], [[3r61\|3r61]], [[2ev6\|2ev6]], [[4hv6\|4hv6]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [https://pdbe.org/4hv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [https://www.ebi.ac.uk/pdbsum/4hv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hv5 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACILLUS SUBTILIS, BSU24520, mntR, yqhN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [~~http~~://pdbe.org/4hv5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hv5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hv5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.	+	[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-	[[Category: ~~Brophy, M B~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Glasfeld, A~~]]	+	[[Category: Brophy MB]]
-	[[Category: ~~Griner, S L~~]]	+	[[Category: Glasfeld A]]
-	[[Category: ~~Kliegman, J I~~]]	+	[[Category: Griner SL]]
-	[[Category: ~~Transcription]]~~	+	[[Category: Kliegman JI]]
-	~~[[Category: Transcription regulator]]~~	+
-	~~[[Category: Winged helix-turn-helix~~]]	+

OCA at 14:54, 4 August 2016

OCA — Thu, 04 Aug 2016 14:54:22 GMT

←Older revision		Revision as of 14:54, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the MNTR FE2+ complex with E site metal binding==		==Structure of the MNTR FE2+ complex with E site metal binding==
	<StructureSection load='4hv5' size='340' side='right' caption='[[4hv5]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4hv5' size='340' side='right' caption='[[4hv5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5d\|2f5d]], [[3r61\|3r61]], [[2ev6\|2ev6]], [[4hv6\|4hv6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5d\|2f5d]], [[3r61\|3r61]], [[2ev6\|2ev6]], [[4hv6\|4hv6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACILLUS SUBTILIS, BSU24520, mntR, yqhN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 ~~Bacillus subtilis subsp. subtilis str. 168~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACILLUS SUBTILIS, BSU24520, mntR, yqhN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [http://pdbe.org/4hv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hv5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hv5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus subtilis subsp. subtilis str. 168~~]]	+	[[Category: Bacsu]]
	[[Category: Brophy, M B]]		[[Category: Brophy, M B]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 16:00, 24 December 2014

OCA — Wed, 24 Dec 2014 16:00:23 GMT

←Older revision		Revision as of 16:00, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:30, 21 December 2014

OCA — Sun, 21 Dec 2014 12:30:12 GMT

←Older revision		Revision as of 12:30, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hv5\| PDB=4hv5 \| SCENE= }}~~	+	==Structure of the MNTR FE2+ complex with E site metal binding==
-	===Structure of the MNTR FE2+ complex with E site metal binding===	+	<StructureSection load='4hv5' size='340' side='right' caption='[[4hv5]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23298157}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HV5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f5d\|2f5d]], [[3r61\|3r61]], [[2ev6\|2ev6]], [[4hv6\|4hv6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACILLUS SUBTILIS, BSU24520, mntR, yqhN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 Bacillus subtilis subsp. subtilis str. 168])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The manganese transport regulator (MntR) represses the expression of genes involved in manganese uptake in Bacillus subtilis. It selectively responds to Mn(2+) and Cd(2+) over other divalent metal cations, including Fe(2+), Co(2+), and Zn(2+). Previous work has shown that MntR forms binuclear complexes with Mn(2+) or Cd(2+) at two binding sites, labeled A and C, that are separated by 4.4 A. Zinc activates MntR poorly and binds only to the A site, forming a mononuclear complex. The difference in metal binding stoichiometry suggested a mechanism for selectivity in MntR. Larger metal cations are strongly activating because they can form the binuclear complex, while smaller metal ions cannot bind with the geometry needed to fully occupy both metal binding sites. To investigate this hypothesis, structures of MntR in complex with two other noncognate metal ions, Fe(2+) and Co(2+), have been determined. Each metal forms a mononuclear complex with MntR with the metal ion bound in the A site, supporting the conclusions drawn from the Zn(2+) complex. Additionally, we investigated two site-specific mutants of MntR, E11K and H77A, that contain substitutions of metal binding residues in the A site. While metal binding in each mutant is significantly altered relative to that of wild-type MntR, both mutants retain activity and selectivity for Mn(2+) in vitro and in vivo. That observation, coupled with previous studies, suggests that the A and C sites both contribute to the selectivity of MntR.

-	~~==Function==~~	+	Roles of the A and C Sites in the Manganese-Specific Activation of MntR.,McGuire AM, Cuthbert BJ, Ma Z, Grauer-Gray KD, Brunjes Brophy M, Spear KA, Soonsanga S, Kliegman JI, Griner SL, Helmann JD, Glasfeld A Biochemistry. 2013 Jan 29;52(4):701-13. doi: 10.1021/bi301550t. Epub 2013 Jan 17. PMID:23298157<ref>PMID:23298157</ref>
-	~~[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator~~ of ~~manganese homeostasis. In~~ the ~~presence~~ of ~~manganese~~, ~~it mediates repression of the manganese transporter MntH; under low manganese conditions~~, ~~it activates the transcription of the mntABCD operon~~.	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hv5]] is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA].	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis subsp. subtilis str. 168]]		[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-	[[Category: Brophy, M B.]]	+	[[Category: Brophy, M B]]
-	[[Category: Glasfeld, A.]]	+	[[Category: Glasfeld, A]]
-	[[Category: Griner, S L.]]	+	[[Category: Griner, S L]]
-	[[Category: Kliegman, J I.]]	+	[[Category: Kliegman, J I]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]
	[[Category: Winged helix-turn-helix]]		[[Category: Winged helix-turn-helix]]

OCA at 19:19, 17 April 2013

OCA — Wed, 17 Apr 2013 19:19:07 GMT

←Older revision		Revision as of 19:19, 17 April 2013
Line 1:		Line 1:
-	[[Image:4hv5.jpg\|left\|200px]]
-
	{{STRUCTURE_4hv5\| PDB=4hv5 \| SCENE= }}		{{STRUCTURE_4hv5\| PDB=4hv5 \| SCENE= }}
-
	===Structure of the MNTR FE2+ complex with E site metal binding===		===Structure of the MNTR FE2+ complex with E site metal binding===
		+	{{ABSTRACT_PUBMED_23298157}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.

	==About this Structure==		==About this Structure==

OCA: Protected "4hv5" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 07:01:05 GMT

Protected "4hv5" [edit=sysop:move=sysop]

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Revision as of 07:01, 14 November 2012

OCA: New page: 200px {{STRUCTURE_4hv5| PDB=4hv5 | SCENE= }} ===Structure of the MNTR FE2+ complex with E site metal binding=== ==About this Structure== 4hv5 is a 2 ch...

OCA — Wed, 14 Nov 2012 07:01:02 GMT

New page: 200px {{STRUCTURE_4hv5| PDB=4hv5 | SCENE= }} ===Structure of the MNTR FE2+ complex with E site metal binding=== ==About this Structure== 4hv5 is a 2 ch...

New page

[[Image:4hv5.jpg|left|200px]]

{{STRUCTURE_4hv5| PDB=4hv5 | SCENE= }}

===Structure of the MNTR FE2+ complex with E site metal binding===

==About this Structure==
[[4hv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV5 OCA].
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Brophy, M B.]]
[[Category: Glasfeld, A.]]
[[Category: Griner, S L.]]
[[Category: Kliegman, J I.]]
[[Category: Transcription]]
[[Category: Transcription regulator]]
[[Category: Winged helix-turn-helix]]