4hw3 - Revision history

OCA at 11:46, 1 March 2024

OCA — Fri, 01 Mar 2024 11:46:17 GMT

←Older revision		Revision as of 11:46, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [https://pdbe.org/4hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [https://pdbe.org/4hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>		[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. NMR-based screening of a large fragment library identified two chemically distinct hit series that bind to different sites on Mcl-1. Members of the two fragment classes were merged together to produce lead compounds that bind to Mcl-1 with a dissociation constant of <100 nM with selectivity for Mcl-1 over Bcl-xL and Bcl-2. Structures of merged compounds when complexed to Mcl-1 were obtained by X-ray crystallography and provide detailed information about the molecular recognition of small-molecule ligands binding Mcl-1. The compounds represent starting points for the discovery of clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers.
-
-	Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design.,Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW J Med Chem. 2012 Dec 17. PMID:23244564<ref>PMID:23244564</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:19, 9 November 2022

OCA — Wed, 09 Nov 2022 08:19:00 GMT

←Older revision		Revision as of 08:19, 9 November 2022
Line 1:		Line 1:

	==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==		==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==
-	<StructureSection load='4hw3' size='340' side='right' caption='[[4hw3]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4hw3' size='340' side='right'caption='[[4hw3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hw2\|4hw2]], [[4hw4\|4hw4]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [https://pdbe.org/4hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [~~http~~://pdbe.org/4hw3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>	+	[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Zhao, B~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Apoptosis]]~~	+	[[Category: Zhao B]]
-	~~[[Category: Apoptosis-inhibitor complex]]~~	+
-	~~[[Category: Maintenance of viability]]~~	+
-	~~[[Category: Regulation of apoptosis~~]]	+

OCA at 10:17, 5 August 2016

OCA — Fri, 05 Aug 2016 10:17:09 GMT

←Older revision		Revision as of 10:17, 5 August 2016
Line 1:		Line 1:
		+
	==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==		==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==
	<StructureSection load='4hw3' size='340' side='right' caption='[[4hw3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4hw3' size='340' side='right' caption='[[4hw3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hw2\|4hw2]], [[4hw4\|4hw4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hw2\|4hw2]], [[4hw4\|4hw4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hw3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [http://pdbe.org/4hw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Zhao, B]]		[[Category: Zhao, B]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 17:59, 25 December 2014

OCA — Thu, 25 Dec 2014 17:59:01 GMT

←Older revision		Revision as of 17:59, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hw3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hw3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:00, 10 December 2014

OCA — Wed, 10 Dec 2014 17:00:28 GMT

←Older revision		Revision as of 17:00, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4hw3.~~png~~\|~~left~~\|~~200px~~]]	+	==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==
		+	<StructureSection load='4hw3' size='340' side='right' caption='[[4hw3]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HW3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hw2\|4hw2]], [[4hw4\|4hw4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hw3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of potent and selective Mcl-1 inhibitors using fragment-based methods and structure-based design. NMR-based screening of a large fragment library identified two chemically distinct hit series that bind to different sites on Mcl-1. Members of the two fragment classes were merged together to produce lead compounds that bind to Mcl-1 with a dissociation constant of <100 nM with selectivity for Mcl-1 over Bcl-xL and Bcl-2. Structures of merged compounds when complexed to Mcl-1 were obtained by X-ray crystallography and provide detailed information about the molecular recognition of small-molecule ligands binding Mcl-1. The compounds represent starting points for the discovery of clinically useful Mcl-1 inhibitors for the treatment of a wide variety of cancers.

-	~~{{STRUCTURE_4hw3\| PDB=4hw3 \| SCENE= }}~~	+	Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design.,Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW J Med Chem. 2012 Dec 17. PMID:23244564<ref>PMID:23244564</ref>

-	~~===Discovery~~ of ~~potent Mcl-1 inhibitors using fragment-based methods and structure-based design===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23244564}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4hw3]] is a 12 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA].~~	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Zhao, B.]]	+	[[Category: Zhao, B]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Apoptosis-inhibitor complex]]		[[Category: Apoptosis-inhibitor complex]]
	[[Category: Maintenance of viability]]		[[Category: Maintenance of viability]]
	[[Category: Regulation of apoptosis]]		[[Category: Regulation of apoptosis]]

OCA at 13:09, 6 March 2013

OCA — Wed, 06 Mar 2013 13:09:48 GMT

←Older revision		Revision as of 13:09, 6 March 2013
Line 1:		Line 1:
-	[[Image:4hw3.~~jpg~~\|left\|200px]]	+	[[Image:4hw3.png\|left\|200px]]

	{{STRUCTURE_4hw3\| PDB=4hw3 \| SCENE= }}		{{STRUCTURE_4hw3\| PDB=4hw3 \| SCENE= }}

OCA at 08:12, 9 January 2013

OCA — Wed, 09 Jan 2013 08:12:32 GMT

←Older revision		Revision as of 08:12, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hw3.jpg\|left\|200px]]

-	~~The entry~~ 4hw3 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hw3\| PDB=4hw3 \| SCENE= }}

-	~~Authors: Zhao, B.~~	+	===Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design===

-	~~Description~~: ~~Discovery of potent Mcl~~-~~1 inhibitors using fragment~~-~~based methods and structure-based design~~	+	{{ABSTRACT_PUBMED_23244564}}
		+
		+	==About this Structure==
		+	[[4hw3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Zhao, B.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Apoptosis-inhibitor complex]]
		+	[[Category: Maintenance of viability]]
		+	[[Category: Regulation of apoptosis]]

OCA: Protected "4hw3" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:20:42 GMT

Protected "4hw3" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 14 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hw3 is ON HOLD until Paper Publication Authors: Zhao, B. Description: Discovery of potent Mcl-1 inhibitors using fragment-based methods and struct...

OCA — Wed, 14 Nov 2012 06:20:41 GMT

New page: '''Unreleased structure''' The entry 4hw3 is ON HOLD until Paper Publication Authors: Zhao, B. Description: Discovery of potent Mcl-1 inhibitors using fragment-based methods and struct...

New page

'''Unreleased structure'''

The entry 4hw3 is ON HOLD until Paper Publication

Authors: Zhao, B.

Description: Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design