4hwh - Revision history

OCA at 11:46, 1 March 2024

OCA — Fri, 01 Mar 2024 11:46:51 GMT

←Older revision		Revision as of 11:46, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.895Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [https://pdbe.org/4hwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [https://www.ebi.ac.uk/pdbsum/4hwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [https://pdbe.org/4hwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [https://www.ebi.ac.uk/pdbsum/4hwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).		[https://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The recently identified plant Bcl-2-associated athanogene (BAG) family plays an extensive role in plant programmed cell death (PCD) processes ranging from growth and development to stress responses and even cell death. In the Arabidopsis thaliana BAG (AtBAG) protein family, four members (AtBAG1-4) have a domain organization similar to that of mammalian BAG proteins. Here, crystal structures of the BAG domains (BDs) of AtBAG1-4 have been determined; they have high homology and adopt a structure comprising three short parallel alpha-helices, similar to some mammalian BAG proteins. The crystal structure of a complex of the AtBAG1 ubiquitin-like domain and BAG domain (UBD) with the Hsc70 nucleotide-binding domain (NBD) was also determined. The binding of the AtBAG1 BD to the Hsc70 NBD induces conformational change of the Hsc70 NBD to the open state and reduces the affinity of the NBD for ADP. In vivo studies showed that bag2-1 mutant plants are larger than wild-type plants when growing under normal conditions, indicating that the AtBAG proteins might regulate plant PCD and confer tolerance to stresses in plants. These structural and functional analyses indicate that the AtBAG proteins function as nucleotide-exchange factors for Hsp70/Hsc70 in A. thaliana and that the mechanism of regulation of chaperone-mediated protein folding is conserved in plants.
-
-	Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana.,Fang S, Li L, Cui B, Men S, Shen Y, Yang X Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):934-45. doi:, 10.1107/S0907444913003624. Epub 2013 May 2. PMID:23695238<ref>PMID:23695238</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4hwh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[BAG family proteins 3D structures\|BAG family proteins 3D structures]]		*[[BAG family proteins 3D structures\|BAG family proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:19, 9 November 2022

OCA — Wed, 09 Nov 2022 08:19:53 GMT

←Older revision		Revision as of 08:19, 9 November 2022
Line 1:		Line 1:

	==Crystal structure of ATBAG4==		==Crystal structure of ATBAG4==
-	<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4hwh' size='340' side='right'caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [https://pdbe.org/4hwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [https://www.ebi.ac.uk/pdbsum/4hwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [~~http~~://pdbe.org/4hwh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hwh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).	+	[https://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4hwh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hwh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[BAG family proteins 3D structures\|BAG family proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Fang, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Shen, Y~~]]	+	[[Category: Fang S]]
-	[[Category: ~~Apoptosis]]~~	+	[[Category: Shen Y]]
-	~~[[Category: Co-chaperone]]~~	+
-	~~[[Category: Three helix bundle~~]]	+

OCA at 18:43, 1 February 2017

OCA — Wed, 01 Feb 2017 18:43:02 GMT

←Older revision		Revision as of 18:43, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of ATBAG4==		==Crystal structure of ATBAG4==
	<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://pdbe.org/4hwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hwh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:33, 30 April 2015

OCA — Thu, 30 Apr 2015 05:33:27 GMT

←Older revision		Revision as of 05:33, 30 April 2015
Line 2:		Line 2:
	<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Fang, S]]		[[Category: Fang, S]]
	[[Category: Shen, Y]]		[[Category: Shen, Y]]

OCA at 20:07, 24 December 2014

OCA — Wed, 24 Dec 2014 20:07:23 GMT

←Older revision		Revision as of 20:07, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:56, 21 December 2014

OCA — Sun, 21 Dec 2014 12:56:36 GMT

←Older revision		Revision as of 12:56, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hwh\| PDB~~=4hwh \| ~~SCENE~~= }}	+	==Crystal structure of ATBAG4==
-	===~~Crystal~~ structure ~~of ATBAG4~~===	+	<StructureSection load='4hwh' size='340' side='right' caption='[[4hwh]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23695238}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hwh]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwc\|4hwc]], [[4hwd\|4hwd]], [[4hwf\|4hwf]], [[4hwi\|4hwi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At3g51780, atbag4, ATEM1.3, BAG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwh RCSB], [http://www.ebi.ac.uk/pdbsum/4hwh PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently identified plant Bcl-2-associated athanogene (BAG) family plays an extensive role in plant programmed cell death (PCD) processes ranging from growth and development to stress responses and even cell death. In the Arabidopsis thaliana BAG (AtBAG) protein family, four members (AtBAG1-4) have a domain organization similar to that of mammalian BAG proteins. Here, crystal structures of the BAG domains (BDs) of AtBAG1-4 have been determined; they have high homology and adopt a structure comprising three short parallel alpha-helices, similar to some mammalian BAG proteins. The crystal structure of a complex of the AtBAG1 ubiquitin-like domain and BAG domain (UBD) with the Hsc70 nucleotide-binding domain (NBD) was also determined. The binding of the AtBAG1 BD to the Hsc70 NBD induces conformational change of the Hsc70 NBD to the open state and reduces the affinity of the NBD for ADP. In vivo studies showed that bag2-1 mutant plants are larger than wild-type plants when growing under normal conditions, indicating that the AtBAG proteins might regulate plant PCD and confer tolerance to stresses in plants. These structural and functional analyses indicate that the AtBAG proteins function as nucleotide-exchange factors for Hsp70/Hsc70 in A. thaliana and that the mechanism of regulation of chaperone-mediated protein folding is conserved in plants.

-	~~==Function==~~	+	Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana.,Fang S, Li L, Cui B, Men S, Shen Y, Yang X Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):934-45. doi:, 10.1107/S0907444913003624. Epub 2013 May 2. PMID:23695238<ref>PMID:23695238</ref>
-	~~[[http://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as~~ programmed cell death ~~and stress responses~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hwh]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023695238</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Fang, S.]]	+	[[Category: Fang, S]]
-	[[Category: Shen, Y.]]	+	[[Category: Shen, Y]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Co-chaperone]]		[[Category: Co-chaperone]]
	[[Category: Three helix bundle]]		[[Category: Three helix bundle]]

OCA at 08:55, 19 June 2013

OCA — Wed, 19 Jun 2013 08:55:31 GMT

←Older revision		Revision as of 08:55, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hwh\| PDB=4hwh \| SCENE= }}
		+	===Crystal structure of ATBAG4===
		+	{{ABSTRACT_PUBMED_23695238}}

-	~~The entry 4hwh is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BAG4_ARATH BAG4_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).

-	~~Authors~~: ~~Shen, Y~~.~~, Fang, S~~.	+	==About this Structure==
		+	[[4hwh]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWH OCA].

-	~~Description~~: ~~Crystal structure of ATBAG4~~	+	==Reference==
		+	<ref group="xtra">PMID:023695238</ref><references group="xtra"/><references/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Fang, S.]]
		+	[[Category: Shen, Y.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Co-chaperone]]
		+	[[Category: Three helix bundle]]

OCA at 20:45, 12 December 2012

OCA — Wed, 12 Dec 2012 20:45:44 GMT

←Older revision		Revision as of 20:45, 12 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hwh is ON HOLD	+	The entry 4hwh is ON HOLD until Paper Publication

	Authors: Shen, Y., Fang, S.		Authors: Shen, Y., Fang, S.

	Description: Crystal structure of ATBAG4		Description: Crystal structure of ATBAG4

OCA at 14:04, 28 November 2012

OCA — Wed, 28 Nov 2012 14:04:33 GMT

←Older revision		Revision as of 14:04, 28 November 2012
Line 5:		Line 5:
	Authors: Shen, Y., Fang, S.		Authors: Shen, Y., Fang, S.

-	Description: ~~CRYSTAL STRUCTURE OF~~ ATBAG4	+	Description: Crystal structure of ATBAG4

OCA: Protected "4hwh" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:21:06 GMT

Protected "4hwh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:21, 14 November 2012