4hwt - Revision history

OCA at 08:20, 9 November 2022

OCA — Wed, 09 Nov 2022 08:20:58 GMT

←Older revision		Revision as of 08:20, 9 November 2022
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	==Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor==		==Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor==
-	<StructureSection load='4hwt' size='340' side='right' caption='[[4hwt]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4hwt' size='340' side='right'caption='[[4hwt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B2:N-{[3-(2H-INDAZOL-5-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>1B2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1B2:N-{[3-(2H-INDAZOL-5-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>1B2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwo\|4hwo]], [[4hwp\|4hwp]], [[4hwr\|4hwr]], [[4hws\|4hws]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwt OCA], [https://pdbe.org/4hwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwt RCSB], [https://www.ebi.ac.uk/pdbsum/4hwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwt ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwt OCA], [~~http~~://pdbe.org/4hwt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hwt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hwt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYTC_HUMAN SYTC_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Threonine--tRNA ligase~~]]	+	[[Category: Large Structures]]
-	[[Category: Hilgers~~, M T]]~~	+	[[Category: Hilgers MT]]
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex~~]]	+

OCA at 02:13, 5 August 2016

OCA — Fri, 05 Aug 2016 02:13:48 GMT

←Older revision		Revision as of 02:13, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor==		==Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor==
	<StructureSection load='4hwt' size='340' side='right' caption='[[4hwt]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4hwt' size='340' side='right' caption='[[4hwt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hwt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hwt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B2:N-{[3-(2H-INDAZOL-5-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>1B2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B2:N-{[3-(2H-INDAZOL-5-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>1B2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwo\|4hwo]], [[4hwp\|4hwp]], [[4hwr\|4hwr]], [[4hws\|4hws]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwo\|4hwo]], [[4hwp\|4hwp]], [[4hwr\|4hwr]], [[4hws\|4hws]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwt RCSB], [http://www.ebi.ac.uk/pdbsum/4hwt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwt OCA], [http://pdbe.org/4hwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hwt RCSB], [http://www.ebi.ac.uk/pdbsum/4hwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hwt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Threonine--tRNA ligase]]		[[Category: Threonine--tRNA ligase]]
	[[Category: Hilgers, M T]]		[[Category: Hilgers, M T]]

OCA at 13:01, 21 December 2014

OCA — Sun, 21 Dec 2014 13:01:34 GMT

←Older revision		Revision as of 13:01, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hwt\| PDB=4hwt \| SCENE= }}~~	+	==Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor==
-	===Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor===	+	<StructureSection load='4hwt' size='340' side='right' caption='[[4hwt]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23362938}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hwt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B2:N-{[3-(2H-INDAZOL-5-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>1B2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hwo\|4hwo]], [[4hwp\|4hwp]], [[4hwr\|4hwr]], [[4hws\|4hws]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hwt RCSB], [http://www.ebi.ac.uk/pdbsum/4hwt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds occupied the substrate binding site of ThrRS and showed excellent binding affinities for all of the bacterial orthologues tested. Some of the compounds displayed greatly improved bacterial selectivity. Key residues responsible for potency and bacteria/human ThrRS selectivity have been identified. Antimicrobial activity has been achieved against wild-type Haemophilus influenzae and efflux-deficient mutants of Escherichia coli and Burkholderia thailandensis.

-	~~==About this Structure==~~	+	Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.,Teng M, Hilgers MT, Cunningham ML, Borchardt A, Locke JB, Abraham S, Haley G, Kwan BP, Hall C, Hough GW, Shaw KJ, Finn J J Med Chem. 2013 Feb 28;56(4):1748-60. doi: 10.1021/jm301756m. Epub 2013 Feb 12. PMID:23362938<ref>PMID:23362938</ref>
-	~~[[4hwt]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4HWT OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023362938</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Threonine--tRNA ligase]]		[[Category: Threonine--tRNA ligase]]
-	[[Category: Hilgers, M T.]]	+	[[Category: Hilgers, M T]]
	[[Category: Aminoacyl-trna synthetase]]		[[Category: Aminoacyl-trna synthetase]]
	[[Category: Ligase-ligase inhibitor complex]]		[[Category: Ligase-ligase inhibitor complex]]
	[[Category: Protein-inhibitor complex]]		[[Category: Protein-inhibitor complex]]

OCA at 04:07, 20 September 2013

OCA — Fri, 20 Sep 2013 04:07:26 GMT

←Older revision		Revision as of 04:07, 20 September 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hwt\| PDB=4hwt \| SCENE= }}
		+	===Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor===
		+	{{ABSTRACT_PUBMED_23362938}}

-	~~The entry~~ 4hwt is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4hwt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWT OCA].

-	~~Authors~~: Hilgers, M.T.	+	==Reference==
-		+	<ref group="xtra">PMID:023362938</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of human Threonyl~~-~~tRNA~~ synthetase ~~bound to a novel~~ inhibitor	+	[[Category: Homo sapiens]]
		+	[[Category: Threonine--tRNA ligase]]
		+	[[Category: Hilgers, M T.]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Ligase-ligase inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]

OCA at 07:01, 2 May 2013

OCA — Thu, 02 May 2013 07:01:32 GMT

←Older revision		Revision as of 07:01, 2 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hwt is ON HOLD	+	The entry 4hwt is ON HOLD until Paper Publication

	Authors: Hilgers, M.T.		Authors: Hilgers, M.T.

	Description: Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor		Description: Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

OCA: Protected "4hwt" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2012 06:21:27 GMT

Protected "4hwt" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:21, 14 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hwt is ON HOLD Authors: Hilgers, M.T. Description: Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

OCA — Wed, 14 Nov 2012 06:21:26 GMT

New page: '''Unreleased structure''' The entry 4hwt is ON HOLD Authors: Hilgers, M.T. Description: Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

New page

'''Unreleased structure'''

The entry 4hwt is ON HOLD

Authors: Hilgers, M.T.

Description: Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor