4hww - Revision history

OCA at 15:12, 20 September 2023

OCA — Wed, 20 Sep 2023 15:12:05 GMT

←Older revision		Revision as of 15:12, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.298Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [https://pdbe.org/4hww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [https://www.ebi.ac.uk/pdbsum/4hww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hww ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [https://pdbe.org/4hww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [https://www.ebi.ac.uk/pdbsum/4hww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hww ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:21, 9 November 2022

OCA — Wed, 09 Nov 2022 08:21:17 GMT

←Older revision		Revision as of 08:21, 9 November 2022
Line 1:		Line 1:

	==Crystal structure of human Arginase-1 complexed with inhibitor 9==		==Crystal structure of human Arginase-1 complexed with inhibitor 9==
-	<StructureSection load='4hww' size='340' side='right' caption='[[4hww]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4hww' size='340' side='right'caption='[[4hww]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[2aeb\|2aeb]], [[4hxq\|4hxq]], [[4hze\|4hze]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [https://pdbe.org/4hww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [https://www.ebi.ac.uk/pdbsum/4hww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hww ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [~~http~~://pdbe.org/4hww PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hww PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hww ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[~~http~~://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>	+	[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4hww" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hww" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginase 3D structures\|Arginase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arginase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Andreoli, M]]	+	[[Category: Andreoli M]]
-	[[Category: Beckett, P]]	+	[[Category: Beckett P]]
-	[[Category: Conway, B]]	+	[[Category: Conway B]]
-	[[Category: Cousido-Siah, A]]	+	[[Category: Cousido-Siah A]]
-	[[Category: Golebiowski, A]]	+	[[Category: Golebiowski A]]
-	[[Category: Ji, M]]	+	[[Category: Ji M]]
-	[[Category: Mahboubi, K]]	+	[[Category: Mahboubi K]]
-	[[Category: Mitschler, A]]	+	[[Category: Mitschler A]]
-	[[Category: Podjarny, A]]	+	[[Category: Podjarny A]]
-	[[Category: Ruiz~~, F X~~]]	+	[[Category: Ruiz FX]]
-	[[Category: Schroeter, H]]	+	[[Category: Schroeter H]]
-	[[Category: Sheeler, R]]	+	[[Category: Sheeler R]]
-	[[Category: ~~Whitehouse, D L~~]]	+	[[Category: Van Zandt MC]]
-	[[Category: ~~Zandt, M C.Van~~]]	+	[[Category: Whitehouse DL]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Alpha/beta fold]]~~	+
-	~~[[Category: Arginine metabolism]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Metalloenzyme~~]]	+

OCA at 20:01, 24 January 2018

OCA — Wed, 24 Jan 2018 20:01:03 GMT

←Older revision		Revision as of 20:01, 24 January 2018
Line 28:		Line 28:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Andreoli, M]]		[[Category: Andreoli, M]]
-	[[Category: Beckett , P]]	+	[[Category: Beckett, P]]
	[[Category: Conway, B]]		[[Category: Conway, B]]
	[[Category: Cousido-Siah, A]]		[[Category: Cousido-Siah, A]]

OCA at 08:46, 15 November 2017

OCA — Wed, 15 Nov 2017 08:46:24 GMT

←Older revision		Revision as of 08:46, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4hww" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hww" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Arginase\|Arginase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:48, 4 August 2016

OCA — Thu, 04 Aug 2016 12:48:03 GMT

←Older revision		Revision as of 12:48, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human Arginase-1 complexed with inhibitor 9==		==Crystal structure of human Arginase-1 complexed with inhibitor 9==
	<StructureSection load='4hww' size='340' side='right' caption='[[4hww]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4hww' size='340' side='right' caption='[[4hww]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[2aeb\|2aeb]], [[4hxq\|4hxq]], [[4hze\|4hze]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[2aeb\|2aeb]], [[4hxq\|4hxq]], [[4hze\|4hze]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [http://www.ebi.ac.uk/pdbsum/4hww PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [http://pdbe.org/4hww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [http://www.ebi.ac.uk/pdbsum/4hww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hww ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hww" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Andreoli, M]]		[[Category: Andreoli, M]]
	[[Category: Beckett , P]]		[[Category: Beckett , P]]

OCA at 09:26, 25 December 2014

OCA — Thu, 25 Dec 2014 09:26:47 GMT

←Older revision		Revision as of 09:26, 25 December 2014
Line 11:		Line 11:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>		[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
-	== Function ==
-
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:49, 21 December 2014

OCA — Sun, 21 Dec 2014 12:49:45 GMT

←Older revision		Revision as of 12:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hww\| PDB=4hww \| SCENE= }}~~	+	==Crystal structure of human Arginase-1 complexed with inhibitor 9==
-	===Crystal structure of human Arginase-1 complexed with inhibitor 9===	+	<StructureSection load='4hww' size='340' side='right' caption='[[4hww]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23472952}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4hww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWW FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X7A:[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X7A</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[2aeb\|2aeb]], [[4hxq\|4hxq]], [[4hze\|4hze]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hww RCSB], [http://www.ebi.ac.uk/pdbsum/4hww PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>		[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
		+	== Function ==
		+
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent alpha,alpha-disubstituted amino acid-based arginase inhibitors. The lead candidate, (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid, compound 9, inhibits human arginases I and II with IC50s of 223 and 509 nM, respectively, and is active in a recombinant cellular assay overexpressing human arginase I (CHO cells). It is 28% orally bioavailable and significantly reduces the infarct size in a rat model of myocardial ischemia/reperfusion injury. Herein, we report the design, synthesis, and structure-activity relationships (SAR) for this novel series of inhibitors along with pharmacokinetic and in vivo efficacy data for compound 9 and X-ray crystallography data for selected lead compounds cocrystallized with arginases I and II.
		+
		+	Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.,Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M, Conway B, Mahboubi K, D'Angelo G, Mitschler A, Cousido-Siah A, Ruiz FX, Howard EI, Podjarny AD, Schroeter H J Med Chem. 2013 Mar 28;56(6):2568-80. doi: 10.1021/jm400014c. Epub 2013 Mar 8. PMID:23472952<ref>PMID:23472952</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hww]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Arginase\|Arginase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Andreoli, M.]]	+	[[Category: Andreoli, M]]
-	[[Category: Beckett , P.]]	+	[[Category: Beckett , P]]
-	[[Category: Conway, B.]]	+	[[Category: Conway, B]]
-	[[Category: Cousido-Siah, A.]]	+	[[Category: Cousido-Siah, A]]
-	[[Category: Golebiowski, A.]]	+	[[Category: Golebiowski, A]]
-	[[Category: Ji, M.]]	+	[[Category: Ji, M]]
-	[[Category: Mahboubi, K.]]	+	[[Category: Mahboubi, K]]
-	[[Category: Mitschler, A.]]	+	[[Category: Mitschler, A]]
-	[[Category: Podjarny, A.]]	+	[[Category: Podjarny, A]]
-	[[Category: Ruiz, F X.]]	+	[[Category: Ruiz, F X]]
-	[[Category: Schroeter, H.]]	+	[[Category: Schroeter, H]]
-	[[Category: Sheeler, R.]]	+	[[Category: Sheeler, R]]
-	[[Category: Whitehouse, D L.]]	+	[[Category: Whitehouse, D L]]
-	[[Category: Zandt, M C.Van.]]	+	[[Category: Zandt, M C.Van]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Alpha/beta fold]]		[[Category: Alpha/beta fold]]
	[[Category: Arginine metabolism]]		[[Category: Arginine metabolism]]

OCA at 21:50, 10 April 2013

OCA — Wed, 10 Apr 2013 21:50:31 GMT

←Older revision		Revision as of 21:50, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4hww\| PDB=4hww \| SCENE= }}
		+	===Crystal structure of human Arginase-1 complexed with inhibitor 9===
		+	{{ABSTRACT_PUBMED_23472952}}

-	~~The~~ entry ~~4hww~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>

-	~~Authors~~: ~~Cousido-Siah, A~~.~~, Mitschler, A~~.~~, Ruiz, F~~.X.~~, Whitehouse, D~~.L.~~, Golebiowski, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A~~.	+	==About this Structure==
		+	[[4hww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA].

-	~~Description~~: ~~Crystal structure of human~~ Arginase-~~1 complexed with~~ inhibitor 9	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Arginase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Andreoli, M.]]
		+	[[Category: Beckett , P.]]
		+	[[Category: Conway, B.]]
		+	[[Category: Cousido-Siah, A.]]
		+	[[Category: Golebiowski, A.]]
		+	[[Category: Ji, M.]]
		+	[[Category: Mahboubi, K.]]
		+	[[Category: Mitschler, A.]]
		+	[[Category: Podjarny, A.]]
		+	[[Category: Ruiz, F X.]]
		+	[[Category: Schroeter, H.]]
		+	[[Category: Sheeler, R.]]
		+	[[Category: Whitehouse, D L.]]
		+	[[Category: Zandt, M C.Van.]]
		+	[[Category: Zhang, M.]]
		+	[[Category: Alpha/beta fold]]
		+	[[Category: Arginine metabolism]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Manganese]]
		+	[[Category: Metalloenzyme]]

OCA at 11:57, 30 January 2013

OCA — Wed, 30 Jan 2013 11:57:20 GMT

←Older revision		Revision as of 11:57, 30 January 2013
Line 3:		Line 3:
	The entry 4hww is ON HOLD until Paper Publication		The entry 4hww is ON HOLD until Paper Publication

-	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., ~~Golebioski~~, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.	+	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.

	Description: Crystal structure of human Arginase-1 complexed with inhibitor 9		Description: Crystal structure of human Arginase-1 complexed with inhibitor 9

OCA at 08:20, 16 January 2013

OCA — Wed, 16 Jan 2013 08:20:54 GMT

←Older revision		Revision as of 08:20, 16 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hww is ON HOLD	+	The entry 4hww is ON HOLD until Paper Publication

	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebioski, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.		Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebioski, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.

-	Description: Crystal structure of human Arginase-1 complexed with inhibitor ~~1337~~	+	Description: Crystal structure of human Arginase-1 complexed with inhibitor 9