4hy6 - Revision history

OCA at 14:11, 8 November 2023

OCA — Wed, 08 Nov 2023 14:11:22 GMT

←Older revision		Revision as of 14:11, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.649Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [https://pdbe.org/4hy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [https://pdbe.org/4hy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:25, 9 November 2022

OCA — Wed, 09 Nov 2022 08:25:43 GMT

←Older revision		Revision as of 08:25, 9 November 2022
Line 1:		Line 1:

	==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1==		==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1==
-	<StructureSection load='4hy6' size='340' side='right' caption='[[4hy6]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4hy6' size='340' side='right'caption='[[4hy6]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [https://pdbe.org/4hy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [~~http~~://pdbe.org/4hy6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~He, J H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Li, J~~]]	+	[[Category: He JH]]
-	[[Category: ~~Yang, M~~]]	+	[[Category: Li J]]
-	[[Category: ~~Atp binding]]~~	+	[[Category: Yang M]]
-	~~[[Category: Atp hydrolysis]]~~	+
-	~~[[Category: Chaperone-chaperone inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Molecular chaperone]]~~	+
-	~~[[Category: Molecularchaperone]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 13:14, 5 August 2016

OCA — Fri, 05 Aug 2016 13:14:52 GMT

←Older revision		Revision as of 13:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1==		==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1==
	<StructureSection load='4hy6' size='340' side='right' caption='[[4hy6]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4hy6' size='340' side='right' caption='[[4hy6]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [http://www.ebi.ac.uk/pdbsum/4hy6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [http://pdbe.org/4hy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [http://www.ebi.ac.uk/pdbsum/4hy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: He, J H]]		[[Category: He, J H]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 19:07, 25 December 2014

OCA — Thu, 25 Dec 2014 19:07:47 GMT

←Older revision		Revision as of 19:07, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hy6\| PDB=4hy6 \| SCENE= }}~~	+	==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1==
-	===Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1===	+	<StructureSection load='4hy6' size='340' side='right' caption='[[4hy6]], [[Resolution\|resolution]] 1.65Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4hy6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HY6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ1:6,6-DIMETHYL-3-(TRIFLUOROMETHYL)-1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONE'>FJ1</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hy6 RCSB], [http://www.ebi.ac.uk/pdbsum/4hy6 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4hy6~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA].	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: He, J H.]]	+	[[Category: He, J H]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Yang, M.]]	+	[[Category: Yang, M]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Atp hydrolysis]]		[[Category: Atp hydrolysis]]

OCA at 07:31, 16 May 2013

OCA — Thu, 16 May 2013 07:31:56 GMT

←Older revision		Revision as of 07:31, 16 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hy6\| PDB=4hy6 \| SCENE= }}
		+	===Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1===

-	~~The entry 4hy6~~ is ~~ON HOLD~~ ~~until May 13 2014~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

-	~~Authors~~: ~~Yang, M~~.~~, Li, J~~.~~, He, J~~.H.	+	==About this Structure==
		+	[[4hy6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY6 OCA].

-	~~Description~~: ~~Crystal Structure of the human Hsp90~~-~~alpha N-domain bound to the hsp90~~ inhibitor ~~FJ1~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: He, J H.]]
		+	[[Category: Li, J.]]
		+	[[Category: Yang, M.]]
		+	[[Category: Atp binding]]
		+	[[Category: Atp hydrolysis]]
		+	[[Category: Chaperone-chaperone inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Molecular chaperone]]
		+	[[Category: Molecularchaperone]]
		+	[[Category: Rossmann fold]]

OCA at 14:04, 28 November 2012

OCA — Wed, 28 Nov 2012 14:04:59 GMT

←Older revision		Revision as of 14:04, 28 November 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hy6 is ON HOLD	+	The entry 4hy6 is ON HOLD until May 13 2014

	Authors: Yang, M., Li, J., He, J.H.		Authors: Yang, M., Li, J., He, J.H.

	Description: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1		Description: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1

OCA: Protected "4hy6" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 09:09:39 GMT

Protected "4hy6" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:09, 21 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hy6 is ON HOLD Authors: Yang, M., Li, J., He, J.H. Description: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor F...

OCA — Wed, 21 Nov 2012 09:09:38 GMT

New page: '''Unreleased structure''' The entry 4hy6 is ON HOLD Authors: Yang, M., Li, J., He, J.H. Description: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor F...

New page

'''Unreleased structure'''

The entry 4hy6 is ON HOLD

Authors: Yang, M., Li, J., He, J.H.

Description: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1