4hzl - Revision history

OCA at 15:13, 20 September 2023

OCA — Wed, 20 Sep 2023 15:13:12 GMT

←Older revision		Revision as of 15:13, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Recombinant_Hepatitis_C_virus_H77(5'UTR-NS2)/JFH1_V787A,Q1247L Recombinant Hepatitis C virus H77(5'UTR-NS2)/JFH1_V787A,Q1247L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Recombinant_Hepatitis_C_virus_H77(5'UTR-NS2)/JFH1_V787A,Q1247L Recombinant Hepatitis C virus H77(5'UTR-NS2)/JFH1_V787A,Q1247L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [https://pdbe.org/4hzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [https://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [https://pdbe.org/4hzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [https://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:29, 9 November 2022

OCA — Wed, 09 Nov 2022 08:29:38 GMT

←Older revision		Revision as of 08:29, 9 November 2022
Line 3:		Line 3:
	<StructureSection load='4hzl' size='340' side='right'caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4hzl' size='340' side='right'caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [~~http~~://en.wikipedia.org/wiki/~~Recombinant_hepatitis_c_virus_h77~~(5'~~utr~~-~~ns2~~)/~~jfh1_v787a~~,~~q1247l~~ Recombinant ~~hepatitis c~~ virus ~~h77~~(5'~~utr~~-~~ns2~~)/~~jfh1_v787a~~,~~q1247l~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Recombinant_Hepatitis_C_virus_H77(5'UTR-NS2)/JFH1_V787A,Q1247L Recombinant Hepatitis C virus H77(5'UTR-NS2)/JFH1_V787A,Q1247L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [~~http~~://pdbe.org/4hzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [https://pdbe.org/4hzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [https://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F5BWY6_9HEPC F5BWY6_9HEPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4hzl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4hzl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Deng, L]]	+	[[Category: Deng L]]
-	[[Category: Zhang, P]]	+	[[Category: Zhang P]]
-	~~[[Category: Ig domain]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Neutralizing antibody~~]]	+

OCA at 07:24, 27 March 2019

OCA — Wed, 27 Mar 2019 07:24:00 GMT

←Older revision		Revision as of 07:24, 27 March 2019
Line 1:		Line 1:

	==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==		==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==
-	<StructureSection load='4hzl' size='340' side='right' caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='4hzl' size='340' side='right'caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Deng, L]]		[[Category: Deng, L]]

OCA at 21:18, 4 August 2016

OCA — Thu, 04 Aug 2016 21:18:10 GMT

←Older revision		Revision as of 21:18, 4 August 2016
Line 1:		Line 1:
		+
	==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==		==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==
	<StructureSection load='4hzl' size='340' side='right' caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4hzl' size='340' side='right' caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [http://www.ebi.ac.uk/pdbsum/4hzl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [http://pdbe.org/4hzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [http://www.ebi.ac.uk/pdbsum/4hzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hzl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:09, 21 December 2014

OCA — Sun, 21 Dec 2014 12:09:46 GMT

←Older revision		Revision as of 12:09, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hzl\| PDB=4hzl \| SCENE= }}~~	+	==Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein==
-	===Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein===	+	<StructureSection load='4hzl' size='340' side='right' caption='[[4hzl]], [[Resolution\|resolution]] 2.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23589879}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZL FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzl RCSB], [http://www.ebi.ac.uk/pdbsum/4hzl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatitis C virus (HCV) envelope glycoprotein E2 has been considered as a major target for vaccine design. Epitope II, mapped between residues 427-446 within the E2 protein, elicits antibodies that are either neutralizing or nonneutralizing. The fundamental mechanism of antibody-mediated neutralization at epitope II remains to be defined at the atomic level. Here we report the crystal structure of the epitope II peptide in complex with a monoclonal antibody (mAb#8) capable of neutralizing HCV. The complex structure revealed that this neutralizing antibody engages epitope II via interactions with both the C-terminal alpha-helix and the N-terminal loop using a bifurcated mode of action. Our structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine.

-	~~==About this Structure==~~	+	Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus.,Deng L, Zhong L, Struble E, Duan H, Ma L, Harman C, Yan H, Virata-Theimer ML, Zhao Z, Feinstone S, Alter H, Zhang P Proc Natl Acad Sci U S A. 2013 Apr 15. PMID:23589879<ref>PMID:23589879</ref>
-	~~[[4hzl]] is~~ a ~~6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr~~-~~ns2)/jfh1_v787a,q1247l Recombinant~~ hepatitis c virus ~~h77(5'utr~~-~~ns2)/jfh1_v787a~~,~~q1247l]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4HZL OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Deng, L.]]	+	[[Category: Deng, L]]
-	[[Category: Zhang, P.]]	+	[[Category: Zhang, P]]
	[[Category: Ig domain]]		[[Category: Ig domain]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Neutralizing antibody]]		[[Category: Neutralizing antibody]]

OCA at 07:37, 2 May 2013

OCA — Thu, 02 May 2013 07:37:30 GMT

←Older revision		Revision as of 07:37, 2 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4hzl\| PDB=4hzl \| SCENE= }}
		+	===Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein===
		+	{{ABSTRACT_PUBMED_23589879}}

-	~~The entry~~ 4hzl is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4hzl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_h77(5'utr-ns2)/jfh1_v787a,q1247l Recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZL OCA].
-	~~Authors~~: Deng, L., Zhang, P.	+	[[Category: Mus musculus]]
-		+	[[Category: Deng, L.]]
-	~~Description~~: Neutralizing antibody ~~mAb#8 in complex with the Epitope II of HCV E2 envelope protein~~	+	[[Category: Zhang, P.]]
		+	[[Category: Ig domain]]
		+	[[Category: Immune system]]
		+	[[Category: Neutralizing antibody]]

OCA at 11:07, 23 January 2013

OCA — Wed, 23 Jan 2013 11:07:07 GMT

←Older revision		Revision as of 11:07, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hzl is ON HOLD	+	The entry 4hzl is ON HOLD until Paper Publication

	Authors: Deng, L., Zhang, P.		Authors: Deng, L., Zhang, P.

	Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein		Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein

OCA at 20:46, 12 December 2012

OCA — Wed, 12 Dec 2012 20:46:24 GMT

←Older revision		Revision as of 20:46, 12 December 2012
Line 3:		Line 3:
	The entry 4hzl is ON HOLD		The entry 4hzl is ON HOLD

-	Authors: Deng, L, Zhang, ~~Pei~~	+	Authors: Deng, L., Zhang, P.

	Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein		Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein

OCA: Protected "4hzl" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 09:11:18 GMT

Protected "4hzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:11, 21 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hzl is ON HOLD Authors: Deng, L, Zhang, Pei Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein

OCA — Wed, 21 Nov 2012 09:11:17 GMT

New page: '''Unreleased structure''' The entry 4hzl is ON HOLD Authors: Deng, L, Zhang, Pei Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein

New page

'''Unreleased structure'''

The entry 4hzl is ON HOLD

Authors: Deng, L, Zhang, Pei

Description: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein