4hzt - Revision history

OCA at 08:29, 9 November 2022

OCA — Wed, 09 Nov 2022 08:29:49 GMT

←Older revision		Revision as of 08:29, 9 November 2022
Line 1:		Line 1:

	==Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates==		==Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates==
-	<StructureSection load='4hzt' size='340' side='right' caption='[[4hzt]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4hzt' size='340' side='right'caption='[[4hzt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hzt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4HZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hzt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0ZA:3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4-OXADIAZOL-5(2H)-ONE'>0ZA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0ZA:3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4-OXADIAZOL-5(2H)-ONE'>0ZA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i10\|4i10]], [[4i0z\|4i0z]], [[4i11\|4i11]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [https://pdbe.org/4hzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [https://www.ebi.ac.uk/pdbsum/4hzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzt ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [~~http~~://pdbe.org/4hzt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4hzt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Brecht, E]]	+	[[Category: Brecht E]]
-	[[Category: Yao, N]]	+	[[Category: Yao N]]
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Hydrolysis~~]]	+

OCA at 10:40, 4 August 2016

OCA — Thu, 04 Aug 2016 10:40:08 GMT

←Older revision		Revision as of 10:40, 4 August 2016
Line 1:		Line 1:
		+
	==Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates==		==Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates==
	<StructureSection load='4hzt' size='340' side='right' caption='[[4hzt]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4hzt' size='340' side='right' caption='[[4hzt]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0ZA:3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4-OXADIAZOL-5(2H)-ONE'>0ZA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0ZA:3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4-OXADIAZOL-5(2H)-ONE'>0ZA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i10\|4i10]], [[4i0z\|4i0z]], [[4i11\|4i11]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i10\|4i10]], [[4i0z\|4i0z]], [[4i11\|4i11]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [http://www.ebi.ac.uk/pdbsum/4hzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [http://pdbe.org/4hzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [http://www.ebi.ac.uk/pdbsum/4hzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4hzt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brecht, E]]		[[Category: Brecht, E]]

OCA at 09:02, 24 December 2014

OCA — Wed, 24 Dec 2014 09:02:59 GMT

←Older revision		Revision as of 09:02, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [http://www.ebi.ac.uk/pdbsum/4hzt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [http://www.ebi.ac.uk/pdbsum/4hzt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:02, 21 December 2014

OCA — Sun, 21 Dec 2014 13:02:34 GMT

←Older revision		Revision as of 13:02, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4hzt\| PDB=4hzt \| SCENE= }}~~	+	==Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates==
-	===Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates===	+	<StructureSection load='4hzt' size='340' side='right' caption='[[4hzt]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23465612}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HZT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0ZA:3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4-OXADIAZOL-5(2H)-ONE'>0ZA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i10\|4i10]], [[4i0z\|4i0z]], [[4i11\|4i11]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hzt RCSB], [http://www.ebi.ac.uk/pdbsum/4hzt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure-activity relationship of a series of dihydroisoquinoline BACE-1 inhibitors is described. Application of structure-based design to screening hit 1 yielded sub-micromolar inhibitors. Replacement of the carboxylic acid of 1 was guided by X-ray crystallography, which allowed the replacement of a key water-mediated hydrogen bond. This work culminated in compounds such as 31, which possess good BACE-1 potency, excellent permeability and a low P-gp efflux ratio.

-	~~==Function==~~	+	Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.,Bowers S, Xu YZ, Yuan S, Probst GD, Hom RK, Chan W, Konradi AW, Sham HL, Zhu YL, Beroza P, Pan H, Brecht E, Yao N, Lougheed J, Tam D, Ren Z, Ruslim L, Bova MP, Artis DR Bioorg Med Chem Lett. 2013 Apr 1;23(7):2181-6. doi: 10.1016/j.bmcl.2013.01.103., Epub 2013 Feb 4. PMID:23465612<ref>PMID:23465612</ref>
-	~~[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing~~ of the ~~amyloid precursor protein (APP)~~. ~~Cleaves at the~~ N~~-terminus of the A-beta peptide sequence~~, ~~between residues 671 and 672 of APP~~, ~~leads to the generation and extracellular release of beta-cleaved soluble APP~~, ~~and a corresponding cell-associated C-terminal fragment which is later released by gamma~~-~~secretase~~.~~<ref>PMID~~:~~10677483<~~/~~ref>~~ <ref>PMID:~~20354142~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4hzt]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta secretase\|Beta secretase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Brecht, E.]]	+	[[Category: Brecht, E]]
-	[[Category: Yao, N.]]	+	[[Category: Yao, N]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Hydrolysis]]		[[Category: Hydrolysis]]

OCA at 10:02, 24 April 2013

OCA — Wed, 24 Apr 2013 10:02:34 GMT

←Older revision		Revision as of 10:02, 24 April 2013
Line 1:		Line 1:
-	[[Image:4hzt.jpg\|left\|200px]]
-
	{{STRUCTURE_4hzt\| PDB=4hzt \| SCENE= }}		{{STRUCTURE_4hzt\| PDB=4hzt \| SCENE= }}
-
	===Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates===		===Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates===
		+	{{ABSTRACT_PUBMED_23465612}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

	==About this Structure==		==About this Structure==
	[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA].		[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 14:28, 6 March 2013

OCA — Wed, 06 Mar 2013 14:28:16 GMT

←Older revision		Revision as of 14:28, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4hzt.jpg\|left\|200px]]

-	~~The entry~~ 4hzt ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4hzt\| PDB=4hzt \| SCENE= }}

-	~~Authors: Yao, N., Brecht, E.~~	+	===Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates===

-	~~Description:~~ Structure-~~based design of novel dihydroisoquinoline BACE~~-~~1 inhibitors that do not engage the catalytic aspartates~~	+
		+	==About this Structure==
		+	[[4hzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Brecht, E.]]
		+	[[Category: Yao, N.]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Hydrolysis]]

OCA at 14:16, 27 February 2013

OCA — Wed, 27 Feb 2013 14:16:04 GMT

←Older revision		Revision as of 14:16, 27 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4hzt is ON HOLD	+	The entry 4hzt is ON HOLD until Paper Publication

	Authors: Yao, N., Brecht, E.		Authors: Yao, N., Brecht, E.

	Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates		Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

OCA at 10:30, 5 December 2012

OCA — Wed, 05 Dec 2012 10:30:55 GMT

←Older revision		Revision as of 10:30, 5 December 2012
Line 3:		Line 3:
	The entry 4hzt is ON HOLD		The entry 4hzt is ON HOLD

-	Authors: Yao, ~~Nanhua~~, Brecht, ~~Eric~~	+	Authors: Yao, N., Brecht, E.

	Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates		Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

OCA: Protected "4hzt" [edit=sysop:move=sysop]

OCA — Wed, 21 Nov 2012 09:11:32 GMT

Protected "4hzt" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:11, 21 November 2012

OCA: New page: '''Unreleased structure''' The entry 4hzt is ON HOLD Authors: Yao, Nanhua, Brecht, Eric Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not e...

OCA — Wed, 21 Nov 2012 09:11:31 GMT

New page: '''Unreleased structure''' The entry 4hzt is ON HOLD Authors: Yao, Nanhua, Brecht, Eric Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not e...

New page

'''Unreleased structure'''

The entry 4hzt is ON HOLD

Authors: Yao, Nanhua, Brecht, Eric

Description: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates