4i1n - Revision history

OCA at 08:34, 9 November 2022

OCA — Wed, 09 Nov 2022 08:34:35 GMT

←Older revision		Revision as of 08:34, 9 November 2022
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	==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==		==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==
-	<StructureSection load='4i1n' size='340' side='right' caption='[[4i1n]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='4i1n' size='340' side='right'caption='[[4i1n]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I1N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i13\|4i13]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [https://pdbe.org/4i1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [https://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [~~http~~://pdbe.org/4i1n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	+	[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus glama~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Lama glama]]
-	[[Category: ~~Ecoli~~]]	+	[[Category: Large Structures]]
-	[[Category: Barlow~~, J N~~]]	+	[[Category: Barlow JN]]
-	[[Category: Oyen, D]]	+	[[Category: Oyen D]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	~~[[Category: Alpha/beta fold]]~~	+
-	~~[[Category: Folate derivative]]~~	+
-	~~[[Category: Hydride transfer]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase-immune system complex]]~~	+
-	~~[[Category: Reductase~~]]	+

OCA at 07:16, 5 August 2016

OCA — Fri, 05 Aug 2016 07:16:04 GMT

←Older revision		Revision as of 07:16, 5 August 2016
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		+
	==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==		==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==
	<StructureSection load='4i1n' size='340' side='right' caption='[[4i1n]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4i1n' size='340' side='right' caption='[[4i1n]], [[Resolution\|resolution]] 1.89Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [http://www.ebi.ac.uk/pdbsum/4i1n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [http://pdbe.org/4i1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [http://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:48, 25 December 2014

OCA — Thu, 25 Dec 2014 16:48:15 GMT

←Older revision		Revision as of 16:48, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4i1n\| PDB=4i1n \| SCENE= }}~~	+	==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==
-	===R104A-ca1697 nanobody binding to the binary DHFR.folate complex===	+	<StructureSection load='4i1n' size='340' side='right' caption='[[4i1n]], [[Resolution\|resolution]] 1.89Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i13\|4i13]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folA, tmrA, b0048, JW0047 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [http://www.ebi.ac.uk/pdbsum/4i1n PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4i1n~~]] ~~is a 2 chain structure. Full crystallographic information is available from~~ [~~http~~:~~//oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA~~].	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Camelus glama]]
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: Barlow, J N.]]	+	[[Category: Ecoli]]
-	[[Category: Oyen, D.]]	+	[[Category: Barlow, J N]]
-	[[Category: Steyaert, J.]]	+	[[Category: Oyen, D]]
		+	[[Category: Steyaert, J]]
	[[Category: Alpha/beta fold]]		[[Category: Alpha/beta fold]]
	[[Category: Folate derivative]]		[[Category: Folate derivative]]

OCA at 10:30, 27 November 2013

OCA — Wed, 27 Nov 2013 10:30:23 GMT

←Older revision		Revision as of 10:30, 27 November 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4i1n\| PDB=4i1n \| SCENE= }}
		+	===R104A-ca1697 nanobody binding to the binary DHFR.folate complex===

-	~~The entry 4i1n is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

-	~~Authors~~: Oyen, D., Steyaert, J.~~, Barlow, J.N.~~	+	==About this Structure==
-		+	[[4i1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA].
-	~~Description~~: ~~R104A~~-~~ca1697 nanobody binding to the binary DHFR.folate~~ complex	+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Barlow, J N.]]
		+	[[Category: Oyen, D.]]
		+	[[Category: Steyaert, J.]]
		+	[[Category: Alpha/beta fold]]
		+	[[Category: Folate derivative]]
		+	[[Category: Hydride transfer]]
		+	[[Category: Immunoglobulin fold]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase-immune system complex]]
		+	[[Category: Reductase]]

OCA at 10:48, 24 April 2013

OCA — Wed, 24 Apr 2013 10:48:59 GMT

←Older revision		Revision as of 10:48, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4i1n is ON HOLD	+	The entry 4i1n is ON HOLD until Paper Publication

	Authors: Oyen, D., Steyaert, J., Barlow, J.N.		Authors: Oyen, D., Steyaert, J., Barlow, J.N.

	Description: R104A-ca1697 nanobody binding to the binary DHFR.folate complex		Description: R104A-ca1697 nanobody binding to the binary DHFR.folate complex

OCA: Protected "4i1n" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 14:07:30 GMT

Protected "4i1n" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 28 November 2012

OCA: New page: '''Unreleased structure''' The entry 4i1n is ON HOLD Authors: Oyen, D., Steyaert, J., Barlow, J.N. Description: R104A-ca1697 nanobody binding to the binary DHFR.folate complex

OCA — Wed, 28 Nov 2012 14:07:29 GMT

New page: '''Unreleased structure''' The entry 4i1n is ON HOLD Authors: Oyen, D., Steyaert, J., Barlow, J.N. Description: R104A-ca1697 nanobody binding to the binary DHFR.folate complex

New page

'''Unreleased structure'''

The entry 4i1n is ON HOLD

Authors: Oyen, D., Steyaert, J., Barlow, J.N.

Description: R104A-ca1697 nanobody binding to the binary DHFR.folate complex