4i1r - Revision history

OCA at 11:48, 1 March 2024

OCA — Fri, 01 Mar 2024 11:48:47 GMT

←Older revision		Revision as of 11:48, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1R FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [https://pdbe.org/4i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [https://www.ebi.ac.uk/pdbsum/4i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [https://pdbe.org/4i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [https://www.ebi.ac.uk/pdbsum/4i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1r ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>		[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Second site: In the crystal structure of human MALT1casp-Ig3 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) in complex with the tricyclic phenothiazine derivative thioridazine (violet in the picture), the inhibitor is bound in a hydrophobic pocket far from the active site. This explains the action of phenothiazine derivatives as noncompetitive, reversible inhibitors.
-
-	Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.,Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP Angew Chem Int Ed Engl. 2013 Aug 14. doi: 10.1002/anie.201304290. PMID:23946259<ref>PMID:23946259</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4i1r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:34, 9 November 2022

OCA — Wed, 09 Nov 2022 08:34:50 GMT

←Older revision		Revision as of 08:34, 9 November 2022
Line 1:		Line 1:

	==Human MALT1 (caspase-IG3) in complex with thioridazine==		==Human MALT1 (caspase-IG3) in complex with thioridazine==
-	<StructureSection load='4i1r' size='340' side='right' caption='[[4i1r]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4i1r' size='340' side='right'caption='[[4i1r]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i1p\|4i1p]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [https://pdbe.org/4i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [https://www.ebi.ac.uk/pdbsum/4i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1r ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [~~http~~://pdbe.org/4i1r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i1r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.	+	[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>	+	[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Hopfner, K P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lammens, K~~]]	+	[[Category: Hopfner KP]]
-	[[Category: ~~Schlauderer, F~~]]	+	[[Category: Lammens K]]
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: Schlauderer F]]
-	~~[[Category: Protease~~]]	+

OCA at 21:13, 11 August 2016

OCA — Thu, 11 Aug 2016 21:13:57 GMT

←Older revision		Revision as of 21:13, 11 August 2016
Line 1:		Line 1:
		+
	==Human MALT1 (caspase-IG3) in complex with thioridazine==		==Human MALT1 (caspase-IG3) in complex with thioridazine==
	<StructureSection load='4i1r' size='340' side='right' caption='[[4i1r]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4i1r' size='340' side='right' caption='[[4i1r]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i1p\|4i1p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i1p\|4i1p]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [http://www.ebi.ac.uk/pdbsum/4i1r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [http://pdbe.org/4i1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [http://www.ebi.ac.uk/pdbsum/4i1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1r ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i1r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]
	[[Category: Lammens, K]]		[[Category: Lammens, K]]

OCA at 13:05, 5 January 2015

OCA — Mon, 05 Jan 2015 13:05:12 GMT

←Older revision		Revision as of 13:05, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4i1r\| PDB=4i1r \| SCENE= }}~~	+	==Human MALT1 (caspase-IG3) in complex with thioridazine==
-	===Human MALT1 (caspase-IG3) in complex with thioridazine===	+	<StructureSection load='4i1r' size='340' side='right' caption='[[4i1r]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23946259}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4i1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1R FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZU:10-{2-[(2S)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>LZU</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i1p\|4i1p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i1r RCSB], [http://www.ebi.ac.uk/pdbsum/4i1r PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.		[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>		[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Second site: In the crystal structure of human MALT1casp-Ig3 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) in complex with the tricyclic phenothiazine derivative thioridazine (violet in the picture), the inhibitor is bound in a hydrophobic pocket far from the active site. This explains the action of phenothiazine derivatives as noncompetitive, reversible inhibitors.

-	~~==About this Structure==~~	+	Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.,Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP Angew Chem Int Ed Engl. 2013 Aug 14. doi: 10.1002/anie.201304290. PMID:23946259<ref>PMID:23946259</ref>
-	~~[[4i1r]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4I1R OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023946259</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hopfner, K P.]]	+	[[Category: Hopfner, K P]]
-	[[Category: Lammens, K.]]	+	[[Category: Lammens, K]]
-	[[Category: Schlauderer, F.]]	+	[[Category: Schlauderer, F]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 07:26, 28 August 2013

OCA — Wed, 28 Aug 2013 07:26:33 GMT

←Older revision		Revision as of 07:26, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4i1r\| PDB=4i1r \| SCENE= }}
		+	===Human MALT1 (caspase-IG3) in complex with thioridazine===
		+	{{ABSTRACT_PUBMED_23946259}}

-	~~The entry 4i1r~~ is ~~ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

-	~~Authors~~: ~~Schlauderer, F~~.~~, Lammens, K~~., ~~Hopfner, K~~.P.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>

-	~~Description~~: Protease ~~bound to small molecule~~	+	==About this Structure==
		+	[[4i1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1R OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023946259</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Hopfner, K P.]]
		+	[[Category: Lammens, K.]]
		+	[[Category: Schlauderer, F.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protease]]

OCA at 11:57, 30 January 2013

OCA — Wed, 30 Jan 2013 11:57:50 GMT

←Older revision		Revision as of 11:57, 30 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4i1r is ON HOLD	+	The entry 4i1r is ON HOLD until Paper Publication

	Authors: Schlauderer, F., Lammens, K., Hopfner, K.P.		Authors: Schlauderer, F., Lammens, K., Hopfner, K.P.

	Description: Protease bound to small molecule		Description: Protease bound to small molecule

OCA at 10:31, 5 December 2012

OCA — Wed, 05 Dec 2012 10:31:32 GMT

←Older revision		Revision as of 10:31, 5 December 2012
Line 5:		Line 5:
	Authors: Schlauderer, F., Lammens, K., Hopfner, K.P.		Authors: Schlauderer, F., Lammens, K., Hopfner, K.P.

-	Description: ~~protease~~ bound to small molecule	+	Description: Protease bound to small molecule

OCA: Protected "4i1r" [edit=sysop:move=sysop]

OCA — Wed, 28 Nov 2012 14:07:37 GMT

Protected "4i1r" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 28 November 2012

OCA: New page: '''Unreleased structure''' The entry 4i1r is ON HOLD Authors: Schlauderer, F., Lammens, K., Hopfner, K.P. Description: protease bound to small molecule

OCA — Wed, 28 Nov 2012 14:07:36 GMT

New page: '''Unreleased structure''' The entry 4i1r is ON HOLD Authors: Schlauderer, F., Lammens, K., Hopfner, K.P. Description: protease bound to small molecule

New page

'''Unreleased structure'''

The entry 4i1r is ON HOLD

Authors: Schlauderer, F., Lammens, K., Hopfner, K.P.

Description: protease bound to small molecule