4i4w - Revision history

OCA at 08:42, 9 November 2022

OCA — Wed, 09 Nov 2022 08:42:05 GMT

←Older revision		Revision as of 08:42, 9 November 2022
Line 1:		Line 1:
		+
	==Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement==		==Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement==
-	<StructureSection load='4i4w' size='340' side='right' caption='[[4i4w]], [[Resolution\|resolution]] 1.77Å' scene=''>	+	<StructureSection load='4i4w' size='340' side='right'caption='[[4i4w]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i4w]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I4W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i4w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I4W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4w OCA], [https://pdbe.org/4i4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i4w RCSB], [https://www.ebi.ac.uk/pdbsum/4i4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i4w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4w OCA], [~~http~~://pdbe.org/4i4w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i4w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i4w PDBsum]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Cole, D K~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rizkallah, P J~~]]	+	[[Category: Cole DK]]
-	[[Category: ~~Wooldridge, L~~]]	+	[[Category: Rizkallah PJ]]
-	[[Category: ~~Antigen presentation]]~~	+	[[Category: Wooldridge L]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc i fold]]~~	+
-	~~[[Category: T-cell receptor~~]]	+

OCA at 19:08, 30 November 2015

OCA — Mon, 30 Nov 2015 19:08:42 GMT

←Older revision		Revision as of 19:08, 30 November 2015
Line 2:		Line 2:
	<StructureSection load='4i4w' size='340' side='right' caption='[[4i4w]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='4i4w' size='340' side='right' caption='[[4i4w]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I4W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I4W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i4w RCSB], [http://www.ebi.ac.uk/pdbsum/4i4w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4w OCA], [http://pdbe.org/4i4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i4w RCSB], [http://www.ebi.ac.uk/pdbsum/4i4w PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i4w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cole, D K]]		[[Category: Cole, D K]]
	[[Category: Rizkallah, P J]]		[[Category: Rizkallah, P J]]

OCA at 12:16, 21 December 2014

OCA — Sun, 21 Dec 2014 12:16:27 GMT

←Older revision		Revision as of 12:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}~~	+	==Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement==
-	===Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement===	+	<StructureSection load='4i4w' size='340' side='right' caption='[[4i4w]], [[Resolution\|resolution]] 1.77Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23255554}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I4W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i4w RCSB], [http://www.ebi.ac.uk/pdbsum/4i4w PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The alphabeta T-cell receptors (TCRs) expressed at the CD8(+) T-cell surface interact with short peptide fragments (p), bound to major histocompatibility complex class I (MHCI) molecules. The TCR/pMHCI interaction is pivotal in all aspects of CD8(+) T-cell immunity. However, the rules that govern the outcome of TCR/pMHCI engagement are not entirely understood which is a major barrier to understanding the requirements for both effective immunity and vaccination. Here, we have discovered an unexpected feature of the TCR/pMHCI interaction by showing that any given TCR exhibits an explicit preference for a single MHCI-peptide length. Agonists of non-preferred length were extremely rare, suboptimal and often entirely distinct in sequence. Structural analysis indicated that alterations in peptide length have a major impact on antigenic complexity, to which individual TCRs are unable to adapt. This novel finding demonstrates that the outcome of TCR/pMHCI engagement is determined by peptide length in addition to the sequence identity of the MHCI-bound peptide. Accordingly, the effective recognition of pMHCI antigen, which is a prerequisite for successful CD8(+) T-cell immunity and protective vaccination, can only be achieved by "length-matched" antigen-specific CD8(+) T-cell clonotypes.

-	~~==Disease==~~	+	Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement.,Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L Blood. 2012 Dec 18. PMID:23255554<ref>PMID:23255554</ref>
-	~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are~~ the ~~cause~~ of ~~hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http:~~/~~/omim~~.~~org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin~~, ~~probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta~~-2-~~microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states~~. ~~The capacity to assemble into amyloid fibrils is concentration dependent~~. ~~Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>~~PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:~~19284997~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation~~ of ~~foreign antigens to~~ the ~~immune system~~. ~~[[http://www~~.~~uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component~~ of ~~the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[4i4w]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cole, D K.]]	+	[[Category: Cole, D K]]
-	[[Category: Rizkallah, P J.]]	+	[[Category: Rizkallah, P J]]
-	[[Category: Wooldridge, L.]]	+	[[Category: Wooldridge, L]]
	[[Category: Antigen presentation]]		[[Category: Antigen presentation]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Mhc i fold]]		[[Category: Mhc i fold]]
	[[Category: T-cell receptor]]		[[Category: T-cell receptor]]

OCA at 06:31, 25 March 2013

OCA — Mon, 25 Mar 2013 06:31:50 GMT

←Older revision		Revision as of 06:31, 25 March 2013
Line 1:		Line 1:
-	[[Image:4i4w.png\|left\|200px]]
-
	{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}		{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}
-
	===Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement===		===Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement===
-
	{{ABSTRACT_PUBMED_23255554}}		{{ABSTRACT_PUBMED_23255554}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 12:		Line 14:
	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cole, D K.]]		[[Category: Cole, D K.]]

OCA at 12:51, 6 March 2013

OCA — Wed, 06 Mar 2013 12:51:50 GMT

←Older revision		Revision as of 12:51, 6 March 2013
Line 1:		Line 1:
-	[[Image:4i4w.~~jpg~~\|left\|200px]]	+	[[Image:4i4w.png\|left\|200px]]

	{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}		{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}
Line 9:		Line 9:
	==About this Structure==		==About this Structure==
	[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA].		[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cole, D K.]]		[[Category: Cole, D K.]]

OCA at 09:20, 2 January 2013

OCA — Wed, 02 Jan 2013 09:20:52 GMT

←Older revision		Revision as of 09:20, 2 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4i4w.jpg\|left\|200px]]

-	~~The entry~~ 4i4w ~~is ON HOLD~~	+	{{STRUCTURE_4i4w\| PDB=4i4w \| SCENE= }}

-	~~Authors: Rizkallah, P.J., Wooldridge, L., Cole, D.K.~~	+	===Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement===

-	~~Description~~: ~~Peptide length determines the outcome of~~ T cell receptor~~/peptide-MHCI engagement~~	+	{{ABSTRACT_PUBMED_23255554}}
		+
		+	==About this Structure==
		+	[[4i4w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4W OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Cole, D K.]]
		+	[[Category: Rizkallah, P J.]]
		+	[[Category: Wooldridge, L.]]
		+	[[Category: Antigen presentation]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc i fold]]
		+	[[Category: T-cell receptor]]

OCA at 20:47, 12 December 2012

OCA — Wed, 12 Dec 2012 20:47:48 GMT

←Older revision		Revision as of 20:47, 12 December 2012
Line 3:		Line 3:
	The entry 4i4w is ON HOLD		The entry 4i4w is ON HOLD

-	Authors: Rizkallah, P.J., Wooldridge, L, Cole, D.K.	+	Authors: Rizkallah, P.J., Wooldridge, L., Cole, D.K.

	Description: Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement		Description: Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement

OCA: Protected "4i4w" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 10:34:27 GMT

Protected "4i4w" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 5 December 2012

OCA: New page: '''Unreleased structure''' The entry 4i4w is ON HOLD Authors: Rizkallah, P.J., Wooldridge, L, Cole, D.K. Description: Peptide length determines the outcome of T cell receptor/peptide-M...

OCA — Wed, 05 Dec 2012 10:34:26 GMT

New page: '''Unreleased structure''' The entry 4i4w is ON HOLD Authors: Rizkallah, P.J., Wooldridge, L, Cole, D.K. Description: Peptide length determines the outcome of T cell receptor/peptide-M...

New page

'''Unreleased structure'''

The entry 4i4w is ON HOLD

Authors: Rizkallah, P.J., Wooldridge, L, Cole, D.K.

Description: Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement