4i56 - Revision history

OCA at 08:42, 9 November 2022

OCA — Wed, 09 Nov 2022 08:42:22 GMT

←Older revision		Revision as of 08:42, 9 November 2022
Line 3:		Line 3:
	<StructureSection load='4i56' size='340' side='right'caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4i56' size='340' side='right'caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i56]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~'pseudomonas_mevalonii' 'pseudomonas~~ mevalonii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i56]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CZ:(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic+acid+3,5-dioxide'>1CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CZ:(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic+acid+3,5-dioxide'>1CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i4b\|4i4b]], [[4i64\|4i64]], [[4i6a\|4i6a]], [[4i6w\|4i6w]], [[4i6y\|4i6y]], [[1qax\|1qax]], [[1r7i\|1r7i]], [[1qay\|1qay]], [[1r31\|1r31]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [https://pdbe.org/4i56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [https://www.ebi.ac.uk/pdbsum/4i56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i56 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [~~http~~://pdbe.org/4i56 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i56 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i56 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV]] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.	+	[https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[HMG-CoA Reductase\|HMG-CoA Reductase]]	+	*[[HMG-CoA Reductase 3D structures\|HMG-CoA Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas mevalonii]]
-	[[Category: Hydroxymethylglutaryl-CoA reductase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Crichelow, C J~~]]	+	[[Category: Pseudomonas mevalonii]]
-	[[Category: II~~, J W.Burgner~~]]	+	[[Category: Burgner II JW]]
-	[[Category: Min, J]]	+	[[Category: Crichelow CJ]]
-	[[Category: Rodwell~~, V W~~]]	+	[[Category: Min J]]
-	[[Category: Schmidt, T]]	+	[[Category: Rodwell VW]]
-	[[Category: Stauffacher~~, C V~~]]	+	[[Category: Schmidt T]]
-	[[Category: Steussy~~, C N~~]]	+	[[Category: Stauffacher CV]]
-	[[Category: Wrensford~~, L V]]~~	+	[[Category: Steussy CN]]
-	~~[[Category: Oxidoreductase~~]]	+	[[Category: Wrensford LV]]

OCA at 11:58, 17 July 2019

OCA — Wed, 17 Jul 2019 11:58:54 GMT

←Older revision		Revision as of 11:58, 17 July 2019
Line 1:		Line 1:

	==HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa==		==HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa==
-	<StructureSection load='4i56' size='340' side='right' caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4i56' size='340' side='right'caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pseudomonas_mevalonii' 'pseudomonas mevalonii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I56 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pseudomonas_mevalonii' 'pseudomonas mevalonii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CZ:(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-~~AMINO~~-9H-~~PURIN~~-9-YL)-4-~~HYDROXY~~-3-(~~PHOSPHONOOXY~~)~~TETRAHYDROFURAN~~-2-YL]-3,5,9,21-~~TETRAHYDROXY~~-8,8,21-~~TRIMETHYL~~-10,14-~~DIOXO~~-19-~~THIOXO~~-2,4,6-~~TRIOXA~~-18-~~THIA~~-11,15-~~DIAZA~~-3,5-~~DIPHOSPHATRICOSAN~~-23-~~OIC~~+~~ACID~~+3,5-~~DIOXIDE~~'>1CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CZ:(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic+acid+3,5-dioxide'>1CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i4b\|4i4b]], [[4i64\|4i64]], [[4i6a\|4i6a]], [[4i6w\|4i6w]], [[4i6y\|4i6y]], [[1qax\|1qax]], [[1r7i\|1r7i]], [[1qay\|1qay]], [[1r31\|1r31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i4b\|4i4b]], [[4i64\|4i64]], [[4i6a\|4i6a]], [[4i6w\|4i6w]], [[4i6y\|4i6y]], [[1qax\|1qax]], [[1r7i\|1r7i]], [[1qay\|1qay]], [[1r31\|1r31]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>
Line 30:		Line 30:
	[[Category: Pseudomonas mevalonii]]		[[Category: Pseudomonas mevalonii]]
	[[Category: Hydroxymethylglutaryl-CoA reductase]]		[[Category: Hydroxymethylglutaryl-CoA reductase]]
		+	[[Category: Large Structures]]
	[[Category: Crichelow, C J]]		[[Category: Crichelow, C J]]
	[[Category: II, J W.Burgner]]		[[Category: II, J W.Burgner]]

OCA at 06:05, 5 August 2016

OCA — Fri, 05 Aug 2016 06:05:22 GMT

←Older revision		Revision as of 06:05, 5 August 2016
Line 1:		Line 1:
		+
	==HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa==		==HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa==
	<StructureSection load='4i56' size='340' side='right' caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4i56' size='340' side='right' caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [http://www.ebi.ac.uk/pdbsum/4i56 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [http://pdbe.org/4i56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [http://www.ebi.ac.uk/pdbsum/4i56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i56" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:23, 25 December 2014

OCA — Thu, 25 Dec 2014 16:23:16 GMT

←Older revision		Revision as of 16:23, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [http://www.ebi.ac.uk/pdbsum/4i56 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [http://www.ebi.ac.uk/pdbsum/4i56 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV]] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:14, 21 December 2014

OCA — Sun, 21 Dec 2014 17:14:01 GMT

←Older revision		Revision as of 17:14, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4i56\| PDB=4i56 \| SCENE= }}~~	+	==HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa==
-	===HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa===	+	<StructureSection load='4i56' size='340' side='right' caption='[[4i56]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23802607}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pseudomonas_mevalonii' 'pseudomonas mevalonii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I56 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CZ:(3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]-3,5,9,21-TETRAHYDROXY-8,8,21-TRIMETHYL-10,14-DIOXO-19-THIOXO-2,4,6-TRIOXA-18-THIA-11,15-DIAZA-3,5-DIPHOSPHATRICOSAN-23-OIC+ACID+3,5-DIOXIDE'>1CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i4b\|4i4b]], [[4i64\|4i64]], [[4i6a\|4i6a]], [[4i6w\|4i6w]], [[4i6y\|4i6y]], [[1qax\|1qax]], [[1r7i\|1r7i]], [[1qay\|1qay]], [[1r31\|1r31]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mvaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 'Pseudomonas mevalonii'])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i56 RCSB], [http://www.ebi.ac.uk/pdbsum/4i56 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this study we take advantage of the ability of HMG-CoA reductase (HMGR) from Pseudomonas mevalonii to remain active while in crystallized form to study the changing interactions between the ligands and protein as the first reaction intermediate is created. HMG-CoA reductase catalyzes one of the few double oxidation/reduction reactions in intermediary metabolism that take place in a single active site. Our laboratory has undertaken an exploration of this reaction space using structures of HMG-CoA reductase complexed with various substrate, nucleotide, product, and inhibitor combinations. Focusing in this publication on the first hydride transfer, our structures follow this reduction reaction as the enzyme converts the HMG-CoA thioester from a flat sp2 like geometry to a pyramidal thiohemiacetal configuration consistent with a transition to an sp3 orbital. This change in the geometry propagates through the CoA ligand whose first amide bond is rotated 180 degrees where it anchors a web of hydrogen bonds that weave together the nucleotide, the reaction intermediate, the enzyme and the catalytic residues. This creates a stable intermediate structure prepared for nucleotide exchange and the second reduction reaction within the HMG-CoA reductase active site. Identification of this reaction intermediate provides a template for the development of an inhibitor that would act as an antibiotic effective against the HMG-CoA reductase of methicillin-resistant Staphylococcus aureus.

-	~~==Function==~~	+	A novel role for CoA during hydride transfer in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.,Steussy CN, Critchelow CJ, Schmidt TJ, Min JK, Wrensford LV, Burgner JW, Rodwell VW, Stauffacher CV Biochemistry. 2013 Jun 26. PMID:23802607<ref>PMID:23802607</ref>
-	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/MVAA_PSEMV MVAA_PSEMV]] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4i56]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/'pseudomonas_mevalonii' 'pseudomonas mevalonii']~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[HMG-CoA Reductase\|HMG-CoA Reductase]]		*[[HMG-CoA Reductase\|HMG-CoA Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023802607</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas mevalonii]]		[[Category: Pseudomonas mevalonii]]
	[[Category: Hydroxymethylglutaryl-CoA reductase]]		[[Category: Hydroxymethylglutaryl-CoA reductase]]
-	[[Category: Crichelow, C J.]]	+	[[Category: Crichelow, C J]]
-	[[Category: II, J W.Burgner.]]	+	[[Category: II, J W.Burgner]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: Rodwell, V W.]]	+	[[Category: Rodwell, V W]]
-	[[Category: Schmidt, T.]]	+	[[Category: Schmidt, T]]
-	[[Category: Stauffacher, C V.]]	+	[[Category: Stauffacher, C V]]
-	[[Category: Steussy, C N.]]	+	[[Category: Steussy, C N]]
-	[[Category: Wrensford, L V.]]	+	[[Category: Wrensford, L V]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:50, 25 December 2013

OCA — Wed, 25 Dec 2013 08:50:45 GMT

←Older revision		Revision as of 08:50, 25 December 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_mevalonii Pseudomonas~~ mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA].	+	[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pseudomonas_mevalonii' 'pseudomonas mevalonii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA].
		+
		+	==See Also==
		+	*[[HMG-CoA Reductase\|HMG-CoA Reductase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:023802607</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023802607</ref><references group="xtra"/><references/>
-	[[Category: Hydroxymethylglutaryl-CoA reductase]]
	[[Category: Pseudomonas mevalonii]]		[[Category: Pseudomonas mevalonii]]
		+	[[Category: Hydroxymethylglutaryl-CoA reductase]]
	[[Category: Crichelow, C J.]]		[[Category: Crichelow, C J.]]
	[[Category: II, J W.Burgner.]]		[[Category: II, J W.Burgner.]]

OCA at 04:56, 18 July 2013

OCA — Thu, 18 Jul 2013 04:56:25 GMT

←Older revision		Revision as of 04:56, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4i56\| PDB=4i56 \| SCENE= }}
		+	===HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa===
		+	{{ABSTRACT_PUBMED_23802607}}

-	~~The entry 4i56~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV]] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.

-	~~Authors~~: ~~Steussy, C~~.N.~~, Stauffacher, C~~.~~V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V~~.~~, Min, J~~.~~, Burgner II, J~~.W.	+	==About this Structure==
		+	[[4i56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I56 OCA].

-	~~Description~~: ~~HMG~~-CoA reductase ~~from pseudomonas~~ mevalonii ~~complexed with dithio-HMG-coa~~	+	==Reference==
		+	<ref group="xtra">PMID:023802607</ref><references group="xtra"/><references/>
		+	[[Category: Hydroxymethylglutaryl-CoA reductase]]
		+	[[Category: Pseudomonas mevalonii]]
		+	[[Category: Crichelow, C J.]]
		+	[[Category: II, J W.Burgner.]]
		+	[[Category: Min, J.]]
		+	[[Category: Rodwell, V W.]]
		+	[[Category: Schmidt, T.]]
		+	[[Category: Stauffacher, C V.]]
		+	[[Category: Steussy, C N.]]
		+	[[Category: Wrensford, L V.]]
		+	[[Category: Oxidoreductase]]

OCA at 19:48, 17 April 2013

OCA — Wed, 17 Apr 2013 19:48:46 GMT

←Older revision		Revision as of 19:48, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4i56 is ON HOLD	+	The entry 4i56 is ON HOLD until Paper Publication

	Authors: Steussy, C.N., Stauffacher, C.V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V., Min, J., Burgner II, J.W.		Authors: Steussy, C.N., Stauffacher, C.V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V., Min, J., Burgner II, J.W.

	Description: HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa		Description: HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa

OCA at 11:03, 19 December 2012

OCA — Wed, 19 Dec 2012 11:03:36 GMT

←Older revision		Revision as of 11:03, 19 December 2012
Line 5:		Line 5:
	Authors: Steussy, C.N., Stauffacher, C.V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V., Min, J., Burgner II, J.W.		Authors: Steussy, C.N., Stauffacher, C.V., Schmidt, T., Crichelow, C.J., Rodwell, V.W., Wrensford, L.V., Min, J., Burgner II, J.W.

-	Description: HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa.	+	Description: HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa

OCA: Protected "4i56" [edit=sysop:move=sysop]

OCA — Wed, 05 Dec 2012 10:34:45 GMT

Protected "4i56" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 5 December 2012