4i8x - Revision history

OCA at 15:17, 20 September 2023

OCA — Wed, 20 Sep 2023 15:17:44 GMT

←Older revision		Revision as of 15:17, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I8X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I8X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC+ACID'>6P3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.23Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC+ACID'>6P3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [https://pdbe.org/4i8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [https://www.ebi.ac.uk/pdbsum/4i8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i8x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [https://pdbe.org/4i8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [https://www.ebi.ac.uk/pdbsum/4i8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i8x ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:49, 9 November 2022

OCA — Wed, 09 Nov 2022 08:49:19 GMT

←Older revision		Revision as of 08:49, 9 November 2022
Line 3:		Line 3:
	<StructureSection load='4i8x' size='340' side='right'caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='4i8x' size='340' side='right'caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I8X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I8X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC+ACID'>6P3</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC+ACID'>6P3</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i9h\|4i9h]], [[4i9n\|4i9n]], [[4i9u\|4i9u]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [https://pdbe.org/4i8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [https://www.ebi.ac.uk/pdbsum/4i8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i8x ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [~~http~~://pdbe.org/4i8x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i8x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i8x ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHA_RABIT LDHA_RABIT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Commodore, L]]	+	[[Category: Commodore L]]
-	[[Category: Dalgarno~~, D C~~]]	+	[[Category: Dalgarno DC]]
-	[[Category: Greenfield~~, M T~~]]	+	[[Category: Greenfield MT]]
-	[[Category: Kohlmann, A]]	+	[[Category: Kohlmann A]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	[[Category: Stephan~~, Z G~~]]	+	[[Category: Stephan ZG]]
-	[[Category: Zhou, T]]	+	[[Category: Zhou T]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Fragment]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 07:30, 27 March 2019

OCA — Wed, 27 Mar 2019 07:30:18 GMT

←Older revision		Revision as of 07:30, 27 March 2019
Line 1:		Line 1:

	==Crystal structure of rabbit LDHA in complex with AP27460==		==Crystal structure of rabbit LDHA in complex with AP27460==
-	<StructureSection load='4i8x' size='340' side='right' caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>	+	<StructureSection load='4i8x' size='340' side='right'caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I8X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I8X FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Commodore, L]]		[[Category: Commodore, L]]

OCA at 07:19, 23 December 2016

OCA — Fri, 23 Dec 2016 07:19:21 GMT

←Older revision		Revision as of 07:19, 23 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of rabbit LDHA in complex with AP27460==		==Crystal structure of rabbit LDHA in complex with AP27460==
	<StructureSection load='4i8x' size='340' side='right' caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='4i8x' size='340' side='right' caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i9h\|4i9h]], [[4i9n\|4i9n]], [[4i9u\|4i9u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i9h\|4i9h]], [[4i9n\|4i9n]], [[4i9u\|4i9u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [http://www.ebi.ac.uk/pdbsum/4i8x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [http://pdbe.org/4i8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [http://www.ebi.ac.uk/pdbsum/4i8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i8x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i8x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:54, 10 December 2014

OCA — Wed, 10 Dec 2014 16:54:08 GMT

←Older revision		Revision as of 16:54, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4i8x.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of rabbit LDHA in complex with AP27460==
		+	<StructureSection load='4i8x' size='340' side='right' caption='[[4i8x]], [[Resolution\|resolution]] 2.23Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4i8x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I8X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC+ACID'>6P3</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i9h\|4i9h]], [[4i9n\|4i9n]], [[4i9u\|4i9u]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i8x RCSB], [http://www.ebi.ac.uk/pdbsum/4i8x PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative phosphorylation to generate ATP, a phenomenon known as the Warburg effect. The inhibition of LDH-A by small molecules is therefore of interest for potential cancer treatments. We describe the identification and optimization of LDH-A inhibitors by fragment-based drug discovery. We applied ligand based NMR screening to identify low affinity fragments binding to LDH-A. The dissociation constants (K(d)) and enzyme inhibition (IC(50)) of fragment hits were measured by surface plasmon resonance (SPR) and enzyme assays, respectively. The binding modes of selected fragments were investigated by X-ray crystallography. Fragment growing and linking, followed by chemical optimization, resulted in nanomolar LDH-A inhibitors that demonstrated stoichiometric binding to LDH-A. Selected molecules inhibited lactate production in cells, suggesting target-specific inhibition in cancer cell lines.

-	~~{{STRUCTURE_4i8x\| PDB=4i8x \| SCENE= }}~~	+	Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors.,Kohlmann A, Zech SG, Li F, Zhou T, Squillace RM, Commodore L, Greenfield MT, Lu X, Miller DP, Huang WS, Qi J, Thomas RM, Wang Y, Zhang S, Dodd R, Liu S, Xu R, Xu Y, Miret JJ, Rivera V, Clackson T, Shakespeare WC, Zhu X, Dalgarno DC J Med Chem. 2013 Jan 9. PMID:23302067<ref>PMID:23302067</ref>

-	~~===Crystal structure~~ of ~~rabbit LDHA in complex with AP27460===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23302067}}~~	+	==See Also==
-		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4i8x~~]] ~~is a 8 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Commodore, L.]]	+	[[Category: Commodore, L]]
-	[[Category: Dalgarno, D C.]]	+	[[Category: Dalgarno, D C]]
-	[[Category: Greenfield, M T.]]	+	[[Category: Greenfield, M T]]
-	[[Category: Kohlmann, A.]]	+	[[Category: Kohlmann, A]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Stephan, Z G.]]	+	[[Category: Stephan, Z G]]
-	[[Category: Zhou, T.]]	+	[[Category: Zhou, T]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Fragment]]		[[Category: Fragment]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 13:25, 27 February 2013

OCA — Wed, 27 Feb 2013 13:25:59 GMT

←Older revision		Revision as of 13:25, 27 February 2013
Line 1:		Line 1:
-	[[Image:4i8x.~~jpg~~\|left\|200px]]	+	[[Image:4i8x.png\|left\|200px]]

	{{STRUCTURE_4i8x\| PDB=4i8x \| SCENE= }}		{{STRUCTURE_4i8x\| PDB=4i8x \| SCENE= }}

OCA at 11:39, 23 January 2013

OCA — Wed, 23 Jan 2013 11:39:07 GMT

←Older revision		Revision as of 11:39, 23 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4i8x.jpg\|left\|200px]]

-	~~The entry~~ 4i8x ~~is ON HOLD~~	+	{{STRUCTURE_4i8x\| PDB=4i8x \| SCENE= }}

-	~~Authors: Zhou, T., Stephan, Z.G., Kohlmann, A., Li, F., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.~~	+	===Crystal structure of rabbit LDHA in complex with AP27460===

-	~~Description~~:	+	{{ABSTRACT_PUBMED_23302067}}
		+
		+	==About this Structure==
		+	[[4i8x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8X OCA].
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Commodore, L.]]
		+	[[Category: Dalgarno, D C.]]
		+	[[Category: Greenfield, M T.]]
		+	[[Category: Kohlmann, A.]]
		+	[[Category: Li, F.]]
		+	[[Category: Stephan, Z G.]]
		+	[[Category: Zhou, T.]]
		+	[[Category: Zhu, X.]]
		+	[[Category: Fragment]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 08:54, 2 January 2013

OCA — Wed, 02 Jan 2013 08:54:05 GMT

←Older revision		Revision as of 08:54, 2 January 2013
Line 3:		Line 3:
	The entry 4i8x is ON HOLD		The entry 4i8x is ON HOLD

-	Authors: Zhou, T, Stephan, Z.G., Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C.	+	Authors: Zhou, T., Stephan, Z.G., Kohlmann, A., Li, F., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.

-	Description: ~~Crystal structure of rabbit LDHA in complex with a fragment AP~~	+	Description:

OCA: Protected "4i8x" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 20:51:03 GMT

Protected "4i8x" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:51, 12 December 2012

OCA: New page: '''Unreleased structure''' The entry 4i8x is ON HOLD Authors: Zhou, T, Stephan, Z.G., Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C. Description: Crystal st...

OCA — Wed, 12 Dec 2012 20:51:02 GMT

New page: '''Unreleased structure''' The entry 4i8x is ON HOLD Authors: Zhou, T, Stephan, Z.G., Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C. Description: Crystal st...

New page

'''Unreleased structure'''

The entry 4i8x is ON HOLD

Authors: Zhou, T, Stephan, Z.G., Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C.

Description: Crystal structure of rabbit LDHA in complex with a fragment AP