4i9j - Revision history

OCA at 15:17, 20 September 2023

OCA — Wed, 20 Sep 2023 15:17:58 GMT

←Older revision		Revision as of 15:17, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [https://pdbe.org/4i9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [https://www.ebi.ac.uk/pdbsum/4i9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [https://pdbe.org/4i9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [https://www.ebi.ac.uk/pdbsum/4i9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9j ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:50, 9 November 2022

OCA — Wed, 09 Nov 2022 08:50:25 GMT

←Older revision		Revision as of 08:50, 9 November 2022
Line 1:		Line 1:

	==Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC==		==Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC==
-	<StructureSection load='4i9j' size='340' side='right' caption='[[4i9j]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4i9j' size='340' side='right'caption='[[4i9j]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staae Staae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8y\|4i8y]], [[4i90\|4i90]], [[4i9m\|4i9m]], [[4i9t\|4i9t]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [https://pdbe.org/4i9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [https://www.ebi.ac.uk/pdbsum/4i9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9j ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [~~http~~://pdbe.org/4i9j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i9j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.	+	[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Phosphatidylinositol diacylglycerol-lyase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Staae~~]]	+	[[Category: Staphylococcus aureus subsp. aureus str. Newman]]
-	[[Category: Cheng, J]]	+	[[Category: Cheng J]]
-	[[Category: Gershenson, A]]	+	[[Category: Gershenson A]]
-	[[Category: Goldstein~~, R I~~]]	+	[[Category: Goldstein RI]]
-	[[Category: Roberts~~, M F~~]]	+	[[Category: Roberts MF]]
-	[[Category: Stec, B]]	+	[[Category: Stec B]]
-	~~[[Category: Dic4pc binding]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Phospholipase]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 13:09, 5 August 2016

OCA — Fri, 05 Aug 2016 13:09:21 GMT

←Older revision		Revision as of 13:09, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC==		==Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC==
	<StructureSection load='4i9j' size='340' side='right' caption='[[4i9j]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4i9j' size='340' side='right' caption='[[4i9j]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8y\|4i8y]], [[4i90\|4i90]], [[4i9m\|4i9m]], [[4i9t\|4i9t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8y\|4i8y]], [[4i90\|4i90]], [[4i9m\|4i9m]], [[4i9t\|4i9t]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 ~~Staphylococcus aureus subsp. aureus str. Newman~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [http://www.ebi.ac.uk/pdbsum/4i9j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [http://pdbe.org/4i9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [http://www.ebi.ac.uk/pdbsum/4i9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i9j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Phosphatidylinositol-specific phospholipase~~ C\|~~Phosphatidylinositol-specific phospholipase~~ C]]	+	*[[Phospholipase C\|Phospholipase C]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
-	[[Category: ~~Staphylococcus aureus subsp. aureus str. newman~~]]	+	[[Category: Staae]]
	[[Category: Cheng, J]]		[[Category: Cheng, J]]
	[[Category: Gershenson, A]]		[[Category: Gershenson, A]]

OCA at 19:06, 25 December 2014

OCA — Thu, 25 Dec 2014 19:06:00 GMT

←Older revision		Revision as of 19:06, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4i9j\| PDB=4i9j \| SCENE= }}~~	+	==Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC==
-	===Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC===	+	<StructureSection load='4i9j' size='340' side='right' caption='[[4i9j]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23576432}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9J FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8y\|4i8y]], [[4i90\|4i90]], [[4i9m\|4i9m]], [[4i9t\|4i9t]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 Staphylococcus aureus subsp. aureus str. Newman])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i9j RCSB], [http://www.ebi.ac.uk/pdbsum/4i9j PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.		[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peripheral membrane proteins can be targeted to specific organelles or the plasma membrane by differential recognition of phospholipid headgroups. Although molecular determinants of specificity for several headgroups, including phosphatidylserine and phosphoinositides are well defined, specific recognition of the headgroup of the zwitterionic phosphatidylcholine (PC) is less well understood. In cytosolic proteins the cation-pi box provides a suitable receptor for choline recognition and binding through the trimethylammonium moiety. In PC, this moiety might provide a sufficient handle to bind to peripheral proteins via a cation-pi cage, where the pi systems of two or more aromatic residues are within 4-5 A of the quaternary amine. We prove this hypothesis by engineering the cation-pi box into secreted phosphatidylinositol-specific phospholipase C from Staphylococcus aureus, which lacks specific PC recognition. The N254Y/H258Y variant selectively binds PC-enriched vesicles, and x-ray crystallography reveals N254Y/H258Y binds choline and dibutyroylphosphatidylcholine within the cation-pi motif. Such simple PC recognition motifs could be engineered into a wide variety of secondary structures providing a generally applicable method for specific recognition of PC.
		+
		+	The cation-pi box is a specific phosphatidylcholine membrane targeting motif.,Cheng J, Goldstein R, Gershenson A, Stec B, Roberts MF J Biol Chem. 2013 May 24;288(21):14863-73. doi: 10.1074/jbc.M113.466532. Epub, 2013 Apr 10. PMID:23576432<ref>PMID:23576432</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4i9j]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus_subsp~~.~~_aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023576432</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Phosphatidylinositol-specific phospholipase C\|Phosphatidylinositol-specific phospholipase C]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
	[[Category: Staphylococcus aureus subsp. aureus str. newman]]		[[Category: Staphylococcus aureus subsp. aureus str. newman]]
-	[[Category: Cheng, J.]]	+	[[Category: Cheng, J]]
-	[[Category: Gershenson, A.]]	+	[[Category: Gershenson, A]]
-	[[Category: Goldstein, R I.]]	+	[[Category: Goldstein, R I]]
-	[[Category: Roberts, M F.]]	+	[[Category: Roberts, M F]]
-	[[Category: Stec, B.]]	+	[[Category: Stec, B]]
	[[Category: Dic4pc binding]]		[[Category: Dic4pc binding]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:20, 23 October 2013

OCA — Wed, 23 Oct 2013 05:20:02 GMT

←Older revision		Revision as of 05:20, 23 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4i9j\| PDB=4i9j \| SCENE= }}		{{STRUCTURE_4i9j\| PDB=4i9j \| SCENE= }}
	===Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC===		===Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC===
		+	{{ABSTRACT_PUBMED_23576432}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA].		[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023576432</ref><references group="xtra"/><references/>
	[[Category: Phosphatidylinositol diacylglycerol-lyase]]		[[Category: Phosphatidylinositol diacylglycerol-lyase]]
	[[Category: Staphylococcus aureus subsp. aureus str. newman]]		[[Category: Staphylococcus aureus subsp. aureus str. newman]]

OCA at 22:45, 10 April 2013

OCA — Wed, 10 Apr 2013 22:45:51 GMT

←Older revision		Revision as of 22:45, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4i9j\| PDB=4i9j \| SCENE= }}
		+	===Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC===

-	~~The entry 4i9j is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.

-	~~Authors~~: ~~Goldstein, R~~.I., Cheng, J.~~, Stec, B.,~~ Gershenson, A., Roberts, M.F.	+	==About this Structure==
-		+	[[4i9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._newman Staphylococcus aureus subsp. aureus str. newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9J OCA].
-	~~Description~~: ~~Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S~~. ~~aureus bound to diC4PC~~	+	[[Category: Phosphatidylinositol diacylglycerol-lyase]]
		+	[[Category: Staphylococcus aureus subsp. aureus str. newman]]
		+	[[Category: Cheng, J.]]
		+	[[Category: Gershenson, A.]]
		+	[[Category: Goldstein, R I.]]
		+	[[Category: Roberts, M F.]]
		+	[[Category: Stec, B.]]
		+	[[Category: Dic4pc binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lyase]]
		+	[[Category: Phospholipase]]
		+	[[Category: Tim barrel]]

OCA at 11:08, 23 January 2013

OCA — Wed, 23 Jan 2013 11:08:45 GMT

←Older revision		Revision as of 11:08, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4i9j is ON HOLD	+	The entry 4i9j is ON HOLD until Paper Publication

	Authors: Goldstein, R.I., Cheng, J., Stec, B., Gershenson, A., Roberts, M.F.		Authors: Goldstein, R.I., Cheng, J., Stec, B., Gershenson, A., Roberts, M.F.

	Description: Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC		Description: Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC

OCA: Protected "4i9j" [edit=sysop:move=sysop]

OCA — Wed, 12 Dec 2012 20:51:42 GMT

Protected "4i9j" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:51, 12 December 2012

OCA: New page: '''Unreleased structure''' The entry 4i9j is ON HOLD Authors: Goldstein, R.I., Cheng, J., Stec, B., Gershenson, A., Roberts, M.F. Description: Structure of the N254Y/H258Y mutant of th...

OCA — Wed, 12 Dec 2012 20:51:41 GMT

New page: '''Unreleased structure''' The entry 4i9j is ON HOLD Authors: Goldstein, R.I., Cheng, J., Stec, B., Gershenson, A., Roberts, M.F. Description: Structure of the N254Y/H258Y mutant of th...

New page

'''Unreleased structure'''

The entry 4i9j is ON HOLD

Authors: Goldstein, R.I., Cheng, J., Stec, B., Gershenson, A., Roberts, M.F.

Description: Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC