4ic8 - Revision history

OCA at 11:53, 1 March 2024

OCA — Fri, 01 Mar 2024 11:53:09 GMT

←Older revision		Revision as of 11:53, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [https://pdbe.org/4ic8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ic8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ic8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [https://pdbe.org/4ic8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ic8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ic8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>		[https://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation. We present the crystal structure of ERK5 in complex with an MKK5 construct comprised of the PB1 domain and the linear binding motif. We show that ERK5 has distinct protein-protein interaction surfaces compared with ERK2, which is the closest ERK5 paralog. The two MAPKs have characteristically different physiological functions and their distinct protein-protein interaction surface topography enables them to bind different sets of activators and substrates. Structural and biochemical characterization revealed that the MKK5 PB1 domain cooperates with the MAPK binding linear motif to achieve substrate specific binding, and it also enables co-recruitment of the upstream activating enzyme and the downstream substrate into one signaling competent complex. Studies on present day MAPKs and MKKs hint on the way protein kinase networks may evolve. In particular, they suggest how paralogous enzymes with similar catalytic properties could acquire novel signaling roles by merely changing the way they make physical links to other proteins.
-
-	Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.,Glatz G, Gogl G, Alexa A, Remenyi A J Biol Chem. 2013 Mar 22;288(12):8596-609. doi: 10.1074/jbc.M113.452235. Epub, 2013 Feb 4. PMID:23382384<ref>PMID:23382384</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4ic8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:59, 9 November 2022

OCA — Wed, 09 Nov 2022 08:59:45 GMT

←Older revision		Revision as of 08:59, 9 November 2022
Line 1:		Line 1:

	==Crystal structure of the apo ERK5 kinase domain==		==Crystal structure of the apo ERK5 kinase domain==
-	<StructureSection load='4ic8' size='340' side='right' caption='[[4ic8]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4ic8' size='340' side='right'caption='[[4ic8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ic7\|4ic7]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [https://pdbe.org/4ic8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ic8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ic8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK7, BMK1, ERK5, PRKM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [~~http~~://pdbe.org/4ic8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ic8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ic8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN]] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>	+	[https://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
-	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]	+	*[[Mitogen-activated protein kinase 3D structures\|Mitogen-activated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Mitogen-activated protein kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Gogl, G]]	+	[[Category: Gogl G]]
-	[[Category: Remenyi, A]]	+	[[Category: Remenyi A]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Signaling]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:20, 11 August 2016

OCA — Thu, 11 Aug 2016 12:20:04 GMT

←Older revision		Revision as of 12:20, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the apo ERK5 kinase domain==		==Crystal structure of the apo ERK5 kinase domain==
	<StructureSection load='4ic8' size='340' side='right' caption='[[4ic8]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ic8' size='340' side='right' caption='[[4ic8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ic7\|4ic7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ic7\|4ic7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK7, BMK1, ERK5, PRKM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK7, BMK1, ERK5, PRKM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ic8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [http://pdbe.org/4ic8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ic8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ic8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ic8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Gogl, G]]		[[Category: Gogl, G]]

OCA at 13:13, 5 January 2015

OCA — Mon, 05 Jan 2015 13:13:17 GMT

←Older revision		Revision as of 13:13, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4ic8\| PDB~~=4ic8 \| ~~SCENE~~= }}	+	==Crystal structure of the apo ERK5 kinase domain==
-	===~~Crystal~~ structure of the ~~apo~~ ERK5 ~~kinase domain~~===	+	<StructureSection load='4ic8' size='340' side='right' caption='[[4ic8]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23382384}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IC8 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ic7\|4ic7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPK7, BMK1, ERK5, PRKM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ic8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ic8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ic8 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN]] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>		[[http://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN]] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation. We present the crystal structure of ERK5 in complex with an MKK5 construct comprised of the PB1 domain and the linear binding motif. We show that ERK5 has distinct protein-protein interaction surfaces compared with ERK2, which is the closest ERK5 paralog. The two MAPKs have characteristically different physiological functions and their distinct protein-protein interaction surface topography enables them to bind different sets of activators and substrates. Structural and biochemical characterization revealed that the MKK5 PB1 domain cooperates with the MAPK binding linear motif to achieve substrate specific binding, and it also enables co-recruitment of the upstream activating enzyme and the downstream substrate into one signaling competent complex. Studies on present day MAPKs and MKKs hint on the way protein kinase networks may evolve. In particular, they suggest how paralogous enzymes with similar catalytic properties could acquire novel signaling roles by merely changing the way they make physical links to other proteins.
		+
		+	Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.,Glatz G, Gogl G, Alexa A, Remenyi A J Biol Chem. 2013 Mar 22;288(12):8596-609. doi: 10.1074/jbc.M113.452235. Epub, 2013 Feb 4. PMID:23382384<ref>PMID:23382384</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ic8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023382384</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
-	[[Category: Gogl, G.]]	+	[[Category: Gogl, G]]
-	[[Category: Remenyi, A.]]	+	[[Category: Remenyi, A]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Signaling]]		[[Category: Signaling]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 19:27, 7 August 2013

OCA — Wed, 07 Aug 2013 19:27:01 GMT

←Older revision		Revision as of 19:27, 7 August 2013
Line 1:		Line 1:
-	[[Image:4ic8.jpg\|left\|200px]]
-
	{{STRUCTURE_4ic8\| PDB=4ic8 \| SCENE= }}		{{STRUCTURE_4ic8\| PDB=4ic8 \| SCENE= }}
-
	===Crystal structure of the apo ERK5 kinase domain===		===Crystal structure of the apo ERK5 kinase domain===
		+	{{ABSTRACT_PUBMED_23382384}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN]] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>

	==About this Structure==		==About this Structure==
	[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA].		[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023382384</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]

OCA at 10:44, 13 February 2013

OCA — Wed, 13 Feb 2013 10:44:15 GMT

←Older revision		Revision as of 10:44, 13 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ic8.jpg\|left\|200px]]

-	~~The entry~~ 4ic8 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ic8\| PDB=4ic8 \| SCENE= }}

-	~~Authors: Gogl, G., Remenyi, A.~~	+	===Crystal structure of the apo ERK5 kinase domain===

-	~~Description: Crystal~~ structure ~~of the apo ERK5~~ kinase ~~domain~~	+
		+	==About this Structure==
		+	[[4ic8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IC8 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Mitogen-activated protein kinase]]
		+	[[Category: Gogl, G.]]
		+	[[Category: Remenyi, A.]]
		+	[[Category: Kinase]]
		+	[[Category: Signaling]]
		+	[[Category: Transferase]]

OCA at 08:55, 2 January 2013

OCA — Wed, 02 Jan 2013 08:55:05 GMT

←Older revision		Revision as of 08:55, 2 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ic8 is ON HOLD	+	The entry 4ic8 is ON HOLD until Paper Publication

	Authors: Gogl, G., Remenyi, A.		Authors: Gogl, G., Remenyi, A.

	Description: Crystal structure of the apo ERK5 kinase domain		Description: Crystal structure of the apo ERK5 kinase domain

OCA: Protected "4ic8" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 11:06:57 GMT

Protected "4ic8" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:06, 19 December 2012

OCA: New page: '''Unreleased structure''' The entry 4ic8 is ON HOLD Authors: Gogl, G., Remenyi, A. Description: Crystal structure of the apo ERK5 kinase domain

OCA — Wed, 19 Dec 2012 11:06:56 GMT

New page: '''Unreleased structure''' The entry 4ic8 is ON HOLD Authors: Gogl, G., Remenyi, A. Description: Crystal structure of the apo ERK5 kinase domain

New page

'''Unreleased structure'''

The entry 4ic8 is ON HOLD

Authors: Gogl, G., Remenyi, A.

Description: Crystal structure of the apo ERK5 kinase domain