4ido - Revision history

OCA at 15:20, 20 September 2023

OCA — Wed, 20 Sep 2023 15:20:54 GMT

←Older revision		Revision as of 15:20, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IDO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IDO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.091Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [https://pdbe.org/4ido PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [https://www.ebi.ac.uk/pdbsum/4ido PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ido ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [https://pdbe.org/4ido PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [https://www.ebi.ac.uk/pdbsum/4ido PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ido ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:03, 9 November 2022

OCA — Wed, 09 Nov 2022 09:03:04 GMT

←Older revision		Revision as of 09:03, 9 November 2022
Line 1:		Line 1:

	==human atlastin-1 1-446, C-his6, GDPAlF4-==		==human atlastin-1 1-446, C-his6, GDPAlF4-==
-	<StructureSection load='4ido' size='340' side='right' caption='[[4ido]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='4ido' size='340' side='right'caption='[[4ido]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IDO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IDO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4idn\|4idn]], [[4idp\|4idp]], [[4idq\|4idq]], [[3q5d\|3q5d]], [[3q5e\|3q5e]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [https://pdbe.org/4ido PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [https://www.ebi.ac.uk/pdbsum/4ido PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ido ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATL1, GBP3, SPG3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [~~http~~://pdbe.org/4ido PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ido PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ido ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN]] Hereditary sensory and autonomic neuropathy type 1;Autosomal dominant spastic paraplegia type 3. Spastic paraplegia autosomal dominant 3 (SPG3) [MIM:[~~http~~://omim.org/entry/182600 182600]]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17321752</ref> <ref>PMID:11685207</ref> <ref>PMID:12112092</ref> <ref>PMID:12939451</ref> <ref>PMID:14695538</ref> <ref>PMID:15184642</ref> <ref>PMID:16533974</ref> <ref>PMID:17427918</ref> <ref>PMID:20932283</ref> <ref>PMID:20718791</ref> Hereditary sensory neuropathy 1D (HSN1D) [MIM:[~~http~~://omim.org/entry/613708 613708]]: A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21194679</ref>	+	[https://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN] Hereditary sensory and autonomic neuropathy type 1;Autosomal dominant spastic paraplegia type 3. Spastic paraplegia autosomal dominant 3 (SPG3) [MIM:[https://omim.org/entry/182600 182600]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17321752</ref> <ref>PMID:11685207</ref> <ref>PMID:12112092</ref> <ref>PMID:12939451</ref> <ref>PMID:14695538</ref> <ref>PMID:15184642</ref> <ref>PMID:16533974</ref> <ref>PMID:17427918</ref> <ref>PMID:20932283</ref> <ref>PMID:20718791</ref> Hereditary sensory neuropathy 1D (HSN1D) [MIM:[https://omim.org/entry/613708 613708]: A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21194679</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN]] GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.<ref>PMID:14506257</ref> <ref>PMID:17321752</ref> <ref>PMID:18270207</ref> <ref>PMID:19665976</ref>	+	[https://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN] GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.<ref>PMID:14506257</ref> <ref>PMID:17321752</ref> <ref>PMID:18270207</ref> <ref>PMID:19665976</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	==See Also==		==See Also==
	*[[Atlastin\|Atlastin]]		*[[Atlastin\|Atlastin]]
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[Atlastin 3D structures\|Atlastin 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Benvin~~, N M~~]]	+	[[Category: Large Structures]]
-	[[Category: Byrnes~~, L J~~]]	+	[[Category: Benvin NM]]
-	[[Category: ~~Donnell, J P.~~O]]	+	[[Category: Byrnes LJ]]
-	[[Category: Singh, A]]	+	[[Category: O'Donnell JP]]
-	[[Category: Sondermann, H]]	+	[[Category: Singh A]]
-	[[Category: Szeto, K]]	+	[[Category: Sondermann H]]
-	[[Category: Zipfel~~, W R]]~~	+	[[Category: Szeto K]]
-	~~[[Category: Gtp/gdp binding]]~~	+	[[Category: Zipfel WR]]
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:24, 23 December 2016

OCA — Fri, 23 Dec 2016 07:24:09 GMT

←Older revision		Revision as of 07:24, 23 December 2016
Line 1:		Line 1:
		+
	==human atlastin-1 1-446, C-his6, GDPAlF4-==		==human atlastin-1 1-446, C-his6, GDPAlF4-==
	<StructureSection load='4ido' size='340' side='right' caption='[[4ido]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='4ido' size='340' side='right' caption='[[4ido]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4idn\|4idn]], [[4idp\|4idp]], [[4idq\|4idq]], [[3q5d\|3q5d]], [[3q5e\|3q5e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4idn\|4idn]], [[4idp\|4idp]], [[4idq\|4idq]], [[3q5d\|3q5d]], [[3q5e\|3q5e]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATL1, GBP3, SPG3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATL1, GBP3, SPG3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [http://www.ebi.ac.uk/pdbsum/4ido PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [http://pdbe.org/4ido PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [http://www.ebi.ac.uk/pdbsum/4ido PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ido ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ido" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Atlastin\|Atlastin]]		*[[Atlastin\|Atlastin]]
		+	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Benvin, N M]]		[[Category: Benvin, N M]]
	[[Category: Byrnes, L J]]		[[Category: Byrnes, L J]]

OCA at 16:59, 10 December 2014

OCA — Wed, 10 Dec 2014 16:59:00 GMT

←Older revision		Revision as of 16:59, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4ido.~~png~~\|~~left~~\|~~200px~~]]	+	==human atlastin-1 1-446, C-his6, GDPAlF4-==
		+	<StructureSection load='4ido' size='340' side='right' caption='[[4ido]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ido]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4idn\|4idn]], [[4idp\|4idp]], [[4idq\|4idq]], [[3q5d\|3q5d]], [[3q5e\|3q5e]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATL1, GBP3, SPG3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ido OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ido RCSB], [http://www.ebi.ac.uk/pdbsum/4ido PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN]] Hereditary sensory and autonomic neuropathy type 1;Autosomal dominant spastic paraplegia type 3. Spastic paraplegia autosomal dominant 3 (SPG3) [MIM:[http://omim.org/entry/182600 182600]]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17321752</ref> <ref>PMID:11685207</ref> <ref>PMID:12112092</ref> <ref>PMID:12939451</ref> <ref>PMID:14695538</ref> <ref>PMID:15184642</ref> <ref>PMID:16533974</ref> <ref>PMID:17427918</ref> <ref>PMID:20932283</ref> <ref>PMID:20718791</ref> Hereditary sensory neuropathy 1D (HSN1D) [MIM:[http://omim.org/entry/613708 613708]]: A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21194679</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATLA1_HUMAN ATLA1_HUMAN]] GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.<ref>PMID:14506257</ref> <ref>PMID:17321752</ref> <ref>PMID:18270207</ref> <ref>PMID:19665976</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Atlastin, a member of the dynamin superfamily, is known to catalyse homotypic membrane fusion in the smooth endoplasmic reticulum (ER). Recent studies of atlastin have elucidated key features about its structure and function; however, several mechanistic details, including the catalytic mechanism and GTP hydrolysis-driven conformational changes, are yet to be determined. Here, we present the crystal structures of atlastin-1 bound to GDP.AlF(4)(-) and GppNHp, uncovering an intramolecular arginine finger that stimulates GTP hydrolysis when correctly oriented through rearrangements within the G domain. Utilizing Forster Resonance Energy Transfer, we describe nucleotide binding and hydrolysis-driven conformational changes in atlastin and their sequence. Furthermore, we discovered a nucleotide exchange mechanism that is intrinsic to atlastin's N-terminal domains. Our results indicate that the cytoplasmic domain of atlastin acts as a tether and homotypic interactions are timed by GTP binding and hydrolysis. Perturbation of these mechanisms may be implicated in a group of atlastin-associated hereditary neurodegenerative diseases.

-	~~{{STRUCTURE_4ido\| PDB=4ido \| SCENE= }}~~	+	Structural basis for conformational switching and GTP loading of the large G protein atlastin.,Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294<ref>PMID:23334294</ref>

-	~~===human atlastin-1 1-446~~, ~~C-his6, GDPAlF4-===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23334294}}~~	+	==See Also==
-		+	*[[Atlastin\|Atlastin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4ido~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Benvin, N M.]]	+	[[Category: Benvin, N M]]
-	[[Category: Byrnes, L J.]]	+	[[Category: Byrnes, L J]]
-	[[Category: Donnell, J P.O.]]	+	[[Category: Donnell, J P.O]]
-	[[Category: Singh, A.]]	+	[[Category: Singh, A]]
-	[[Category: Sondermann, H.]]	+	[[Category: Sondermann, H]]
-	[[Category: Szeto, K.]]	+	[[Category: Szeto, K]]
-	[[Category: Zipfel, W R.]]	+	[[Category: Zipfel, W R]]
	[[Category: Gtp/gdp binding]]		[[Category: Gtp/gdp binding]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 12:53, 6 February 2013

OCA — Wed, 06 Feb 2013 12:53:55 GMT

←Older revision		Revision as of 12:53, 6 February 2013
Line 1:		Line 1:
-	[[Image:4ido.~~jpg~~\|left\|200px]]	+	[[Image:4ido.png\|left\|200px]]

	{{STRUCTURE_4ido\| PDB=4ido \| SCENE= }}		{{STRUCTURE_4ido\| PDB=4ido \| SCENE= }}
Line 5:		Line 5:
	===human atlastin-1 1-446, C-his6, GDPAlF4-===		===human atlastin-1 1-446, C-his6, GDPAlF4-===

		+	{{ABSTRACT_PUBMED_23334294}}

	==About this Structure==		==About this Structure==

OCA at 08:25, 9 January 2013

OCA — Wed, 09 Jan 2013 08:25:29 GMT

←Older revision		Revision as of 08:25, 9 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ido.jpg\|left\|200px]]

-	~~The entry~~ 4ido ~~is ON HOLD~~	+	{{STRUCTURE_4ido\| PDB=4ido \| SCENE= }}

-	~~Authors: Byrnes~~, ~~L.J.~~, ~~Singh, A., Szeto, K., Benvin, N.M., O'Donnell, J.P., Zipfel, W.R., Sondermann, H.~~	+	===human atlastin-1 1-446, C-his6, GDPAlF4-===

-	~~Description~~: ~~human atlastin~~-~~1 1-446~~, ~~C-his6~~, ~~GDPAlF4-~~	+
		+	==About this Structure==
		+	[[4ido]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDO OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Benvin, N M.]]
		+	[[Category: Byrnes, L J.]]
		+	[[Category: Donnell, J P.O.]]
		+	[[Category: Singh, A.]]
		+	[[Category: Sondermann, H.]]
		+	[[Category: Szeto, K.]]
		+	[[Category: Zipfel, W R.]]
		+	[[Category: Gtp/gdp binding]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]

OCA at 08:55, 2 January 2013

OCA — Wed, 02 Jan 2013 08:55:41 GMT

←Older revision		Revision as of 08:55, 2 January 2013
Line 3:		Line 3:
	The entry 4ido is ON HOLD		The entry 4ido is ON HOLD

-	Authors: Byrnes, L. J., Singh, A., Szeto, K. , Benvin, N. M. , O'Donnell, J. P. , Zipfel, W. R. , Sondermann, H.	+	Authors: Byrnes, L.J., Singh, A., Szeto, K., Benvin, N.M., O'Donnell, J.P., Zipfel, W.R., Sondermann, H.

	Description: human atlastin-1 1-446, C-his6, GDPAlF4-		Description: human atlastin-1 1-446, C-his6, GDPAlF4-

OCA: Protected "4ido" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 11:08:26 GMT

Protected "4ido" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 19 December 2012

OCA: New page: '''Unreleased structure''' The entry 4ido is ON HOLD Authors: Byrnes, L. J., Singh, A., Szeto, K. , Benvin, N. M. , O'Donnell, J. P. , Zipfel, W. R. , Sondermann, H. Description: human...

OCA — Wed, 19 Dec 2012 11:08:25 GMT

New page: '''Unreleased structure''' The entry 4ido is ON HOLD Authors: Byrnes, L. J., Singh, A., Szeto, K. , Benvin, N. M. , O'Donnell, J. P. , Zipfel, W. R. , Sondermann, H. Description: human...

New page

'''Unreleased structure'''

The entry 4ido is ON HOLD

Authors: Byrnes, L. J., Singh, A., Szeto, K. , Benvin, N. M. , O'Donnell, J. P. , Zipfel, W. R. , Sondermann, H.

Description: human atlastin-1 1-446, C-his6, GDPAlF4-