4iia - Revision history

OCA at 11:57, 1 March 2024

OCA — Fri, 01 Mar 2024 11:57:20 GMT

←Older revision		Revision as of 11:57, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [https://pdbe.org/4iia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [https://www.ebi.ac.uk/pdbsum/4iia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iia ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [https://pdbe.org/4iia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [https://www.ebi.ac.uk/pdbsum/4iia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iia ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>		[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ras GTPase Activating Protein SH3 Domain Binding Protein (G3BP) is a potential anti-cancer drug target implicated in several cellular functions. We have used protein crystallography to solve crystal structures of the human G3BP1 NTF2-like domain both alone and in complex with an FxFG Nup repeat peptide. Despite high structural similarity, the FxFG binding site is located between two alpha helices in the G3BP1 NTF2-like domain and not at the dimer interface as observed for nuclear transport factor 2. ITC studies showed specificity towards the FxFG motif but not FG and GLFG motifs. The unliganded form of the G3BP1 NTF2-like domain was solved in two crystal forms to resolutions of 1.6 and 3.3 A in space groups P212121 and P6322 based on two different constructs, residues 1-139 and 11-139, respectively. Crystal packing of the N-terminal residues against a symmetry related molecule in the P212121 crystal form might indicate a novel ligand binding site that, however, remains to be validated. The crystal structures give insight into the nuclear transportation mechanisms of G3BP and provide a basis for future structure based drug design.
-
-	Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity.,Vognsen T, Moller IR, Kristensen O PLoS One. 2013 Dec 4;8(12):e80947. doi: 10.1371/journal.pone.0080947. PMID:24324649<ref>PMID:24324649</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4iia" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:47, 16 November 2022

OCA — Wed, 16 Nov 2022 20:47:12 GMT

←Older revision		Revision as of 20:47, 16 November 2022
Line 1:		Line 1:

	==Low resolution crystal structure of the NTF2-like domain of human G3BP1==		==Low resolution crystal structure of the NTF2-like domain of human G3BP1==
-	<StructureSection load='4iia' size='340' side='right' caption='[[4iia]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='4iia' size='340' side='right'caption='[[4iia]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iia]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcj\|4fcj]], [[3q90\|3q90]], [[4fcm\|4fcm]], [[3ujm\|3ujm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [https://pdbe.org/4iia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [https://www.ebi.ac.uk/pdbsum/4iia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iia ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">G3BP1, G3BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [~~http~~://pdbe.org/4iia PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iia PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iia ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>	+	[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Kristensen, O~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Moeller, I R~~]]	+	[[Category: Kristensen O]]
-	[[Category: ~~Vognsen, T~~]]	+	[[Category: Moeller IR]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Vognsen T]]
-	~~[[Category: Ntf2-like domain~~]]	+

OCA at 23:07, 5 August 2016

OCA — Fri, 05 Aug 2016 23:07:42 GMT

←Older revision		Revision as of 23:07, 5 August 2016
Line 1:		Line 1:
		+
	==Low resolution crystal structure of the NTF2-like domain of human G3BP1==		==Low resolution crystal structure of the NTF2-like domain of human G3BP1==
	<StructureSection load='4iia' size='340' side='right' caption='[[4iia]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4iia' size='340' side='right' caption='[[4iia]], [[Resolution\|resolution]] 3.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcj\|4fcj]], [[3q90\|3q90]], [[4fcm\|4fcm]], [[3ujm\|3ujm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcj\|4fcj]], [[3q90\|3q90]], [[4fcm\|4fcm]], [[3ujm\|3ujm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">G3BP1, G3BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">G3BP1, G3BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [http://www.ebi.ac.uk/pdbsum/4iia PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [http://pdbe.org/4iia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [http://www.ebi.ac.uk/pdbsum/4iia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iia ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4iia" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:44, 25 December 2014

OCA — Thu, 25 Dec 2014 22:44:15 GMT

←Older revision		Revision as of 22:44, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [http://www.ebi.ac.uk/pdbsum/4iia PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [http://www.ebi.ac.uk/pdbsum/4iia PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:37, 21 December 2014

OCA — Sun, 21 Dec 2014 18:37:27 GMT

←Older revision		Revision as of 18:37, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4iia\| PDB=4iia \| SCENE= }}~~	+	==Low resolution crystal structure of the NTF2-like domain of human G3BP1==
-	===Low resolution crystal structure of the NTF2-like domain of human G3BP1===	+	<StructureSection load='4iia' size='340' side='right' caption='[[4iia]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24324649}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4iia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IIA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fcj\|4fcj]], [[3q90\|3q90]], [[4fcm\|4fcm]], [[3ujm\|3ujm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">G3BP1, G3BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iia OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iia RCSB], [http://www.ebi.ac.uk/pdbsum/4iia PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ras GTPase Activating Protein SH3 Domain Binding Protein (G3BP) is a potential anti-cancer drug target implicated in several cellular functions. We have used protein crystallography to solve crystal structures of the human G3BP1 NTF2-like domain both alone and in complex with an FxFG Nup repeat peptide. Despite high structural similarity, the FxFG binding site is located between two alpha helices in the G3BP1 NTF2-like domain and not at the dimer interface as observed for nuclear transport factor 2. ITC studies showed specificity towards the FxFG motif but not FG and GLFG motifs. The unliganded form of the G3BP1 NTF2-like domain was solved in two crystal forms to resolutions of 1.6 and 3.3 A in space groups P212121 and P6322 based on two different constructs, residues 1-139 and 11-139, respectively. Crystal packing of the N-terminal residues against a symmetry related molecule in the P212121 crystal form might indicate a novel ligand binding site that, however, remains to be validated. The crystal structures give insight into the nuclear transportation mechanisms of G3BP and provide a basis for future structure based drug design.

-	~~==Function==~~	+	Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity.,Vognsen T, Moller IR, Kristensen O PLoS One. 2013 Dec 4;8(12):e80947. doi: 10.1371/journal.pone.0080947. PMID:24324649<ref>PMID:24324649</ref>
-	~~[[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector~~ of ~~stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at~~ the 3'-~~UTR~~. ~~ATP- and magnesium-dependent helicase~~. ~~Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends~~. ~~Unwinds DNA~~/~~DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency~~. ~~Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA~~.~~<ref>~~PMID:~~9889278</ref>~~ <ref>PMID:~~11604510~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4iia]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4IIA OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024324649</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Kristensen, O.]]	+	</StructureSection>
-	[[Category: Moeller, I R.]]	+	[[Category: Human]]
-	[[Category: Vognsen, T.]]	+	[[Category: Kristensen, O]]
		+	[[Category: Moeller, I R]]
		+	[[Category: Vognsen, T]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ntf2-like domain]]		[[Category: Ntf2-like domain]]

OCA at 10:28, 18 December 2013

OCA — Wed, 18 Dec 2013 10:28:32 GMT

←Older revision		Revision as of 10:28, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4iia\| PDB=4iia \| SCENE= }}
		+	===Low resolution crystal structure of the NTF2-like domain of human G3BP1===
		+	{{ABSTRACT_PUBMED_24324649}}

-	~~The entry 4iia is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref>

-	~~Authors~~: ~~Vognsen, T~~.~~, Moeller, I~~.R.~~, Kristensen, O~~.	+	==About this Structure==
		+	[[4iia]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIA OCA].

-	~~Description~~: ~~Low resolution crystal structure of the NTF2~~-like domain ~~of human G3BP1~~	+	==Reference==
		+	<ref group="xtra">PMID:024324649</ref><references group="xtra"/><references/>
		+	[[Category: Kristensen, O.]]
		+	[[Category: Moeller, I R.]]
		+	[[Category: Vognsen, T.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ntf2-like domain]]

OCA at 19:49, 17 April 2013

OCA — Wed, 17 Apr 2013 19:49:54 GMT

←Older revision		Revision as of 19:49, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iia is ON HOLD	+	The entry 4iia is ON HOLD until Paper Publication

	Authors: Vognsen, T., Moeller, I.R., Kristensen, O.		Authors: Vognsen, T., Moeller, I.R., Kristensen, O.

	Description: Low resolution crystal structure of the NTF2-like domain of human G3BP1		Description: Low resolution crystal structure of the NTF2-like domain of human G3BP1

OCA at 11:10, 23 January 2013

OCA — Wed, 23 Jan 2013 11:10:33 GMT

←Older revision		Revision as of 11:10, 23 January 2013
Line 5:		Line 5:
	Authors: Vognsen, T., Moeller, I.R., Kristensen, O.		Authors: Vognsen, T., Moeller, I.R., Kristensen, O.

-	Description: ~~LOW RESOLUTION CRYSTAL STRUCTURE OF THE~~ NTF2-~~LIKE DOMAIN OF HUMAN~~ G3BP1	+	Description: Low resolution crystal structure of the NTF2-like domain of human G3BP1

OCA: Protected "4iia" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 08:59:30 GMT

Protected "4iia" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:59, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 4iia is ON HOLD Authors: Vognsen, T., Moeller, I.R., Kristensen, O. Description: LOW RESOLUTION CRYSTAL STRUCTURE OF THE NTF2-LIKE DOMAIN OF HUMAN ...

OCA — Wed, 02 Jan 2013 08:59:28 GMT

New page: '''Unreleased structure''' The entry 4iia is ON HOLD Authors: Vognsen, T., Moeller, I.R., Kristensen, O. Description: LOW RESOLUTION CRYSTAL STRUCTURE OF THE NTF2-LIKE DOMAIN OF HUMAN ...

New page

'''Unreleased structure'''

The entry 4iia is ON HOLD

Authors: Vognsen, T., Moeller, I.R., Kristensen, O.

Description: LOW RESOLUTION CRYSTAL STRUCTURE OF THE NTF2-LIKE DOMAIN OF HUMAN G3BP1