4iiq - Revision history

OCA at 20:48, 16 November 2022

OCA — Wed, 16 Nov 2022 20:48:44 GMT

←Older revision		Revision as of 20:48, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of a human MAIT TCR in complex with bovine MR1==		==Crystal structure of a human MAIT TCR in complex with bovine MR1==
-	<StructureSection load='4iiq' size='340' side='right' caption='[[4iiq]], [[Resolution\|resolution]] 2.86Å' scene=''>	+	<StructureSection load='4iiq' size='340' side='right'caption='[[4iiq]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iiq]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IIQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iiq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KFP:N~6~-[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]-D-LYSINE'>KFP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=KFP:N~6~-[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]-D-LYSINE'>KFP</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iiq OCA], [https://pdbe.org/4iiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iiq RCSB], [https://www.ebi.ac.uk/pdbsum/4iiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iiq ProSAT]</span></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MR1, Bt.63045 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iiq OCA], [~~http~~://pdbe.org/4iiq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iiq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iiq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iiq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6P4G7_HUMAN Q6P4G7_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4iiq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4iiq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Adams, E J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lopez-Sagaseta, J~~]]	+	[[Category: Adams EJ]]
-	[[Category: ~~Antigen presentation]]~~	+	[[Category: Lopez-Sagaseta J]]
-	~~[[Category: Antigen recognition]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Mhc~~-~~class i~~]]	+

OCA at 22:29, 15 November 2017

OCA — Wed, 15 Nov 2017 22:29:46 GMT

←Older revision		Revision as of 22:29, 15 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4iiq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4iiq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:49, 11 August 2016

OCA — Thu, 11 Aug 2016 12:49:17 GMT

←Older revision		Revision as of 12:49, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a human MAIT TCR in complex with bovine MR1==		==Crystal structure of a human MAIT TCR in complex with bovine MR1==
	<StructureSection load='4iiq' size='340' side='right' caption='[[4iiq]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='4iiq' size='340' side='right' caption='[[4iiq]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IIQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IIQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KFP:N~6~-[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]-D-LYSINE'>KFP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KFP:N~6~-[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]-D-LYSINE'>KFP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MR1, Bt.63045 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MR1, Bt.63045 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iiq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iiq RCSB], [http://www.ebi.ac.uk/pdbsum/4iiq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iiq OCA], [http://pdbe.org/4iiq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iiq RCSB], [http://www.ebi.ac.uk/pdbsum/4iiq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iiq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4iiq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Adams, E J]]		[[Category: Adams, E J]]
	[[Category: Lopez-Sagaseta, J]]		[[Category: Lopez-Sagaseta, J]]

OCA at 12:54, 4 January 2015

OCA — Sun, 04 Jan 2015 12:54:56 GMT

←Older revision		Revision as of 12:54, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4iiq\| PDB=4iiq \| SCENE= }}~~	+	==Crystal structure of a human MAIT TCR in complex with bovine MR1==
-	===Crystal structure of a human MAIT TCR in complex with bovine MR1===	+	<StructureSection load='4iiq' size='340' side='right' caption='[[4iiq]], [[Resolution\|resolution]] 2.86Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23613577}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IIQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KFP:N~6~-[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]-D-LYSINE'>KFP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MR1, Bt.63045 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iiq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iiq RCSB], [http://www.ebi.ac.uk/pdbsum/4iiq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved alphabeta T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT cells are dependent upon MR1 expression and exposure to microbes for their development and stimulation, yet these cells can exhibit microbial-independent stimulation when responding to MR1 from different species. We have used this microbial-independent, cross-species reactivity of MAIT cells to define the molecular basis of MAIT-TCR/MR1 engagement and present here a 2.85 A complex structure of a human MAIT-TCR bound to bovine MR1. The MR1 binding groove is similar in backbone structure to classical peptide-presenting MHC class I molecules (MHCp), yet is partially occluded by large aromatic residues that form cavities suitable for small ligand presentation. The docking of the MAIT-TCR on MR1 is perpendicular to the MR1 surface and straddles the MR1 alpha1 and alpha2 helices, similar to classical alphabeta TCR engagement of MHCp. However, the MAIT-TCR contacts are dominated by the alpha-chain, focused on the MR1 alpha2 helix. TCR beta-chain contacts are mostly through the variable CDR3beta loop that is positioned proximal to the CDR3alpha loop directly over the MR1 open groove. The elucidation of the MAIT TCR/MR1 complex structure explains how the semi-invariant MAIT-TCR engages the nonpolymorphic MR1 protein, and sheds light onto ligand discrimination by this cell type. Importantly, this structure also provides a critical link in our understanding of the evolution of alphabeta T-cell recognition of MHC and MHC-like ligands.

-	~~==About this Structure==~~	+	The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.,Lopez-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1771-8. doi:, 10.1073/pnas.1222678110. Epub 2013 Apr 23. PMID:23613577<ref>PMID:23613577</ref>
-	~~[[4iiq]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus] and [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4IIQ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023613577</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, E J.]]	+	[[Category: Adams, E J]]
-	[[Category: Lopez-Sagaseta, J.]]	+	[[Category: Lopez-Sagaseta, J]]
	[[Category: Antigen presentation]]		[[Category: Antigen presentation]]
	[[Category: Antigen recognition]]		[[Category: Antigen recognition]]

OCA at 14:05, 19 June 2013

OCA — Wed, 19 Jun 2013 14:05:03 GMT

←Older revision		Revision as of 14:05, 19 June 2013
Line 1:		Line 1:
	{{STRUCTURE_4iiq\| PDB=4iiq \| SCENE= }}		{{STRUCTURE_4iiq\| PDB=4iiq \| SCENE= }}
	===Crystal structure of a human MAIT TCR in complex with bovine MR1===		===Crystal structure of a human MAIT TCR in complex with bovine MR1===
		+	{{ABSTRACT_PUBMED_23613577}}

	==About this Structure==		==About this Structure==
	[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA].		[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023613577</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 11:30, 24 April 2013

OCA — Wed, 24 Apr 2013 11:30:18 GMT

←Older revision		Revision as of 11:30, 24 April 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4iiq\| PDB=4iiq \| SCENE= }}
		+	===Crystal structure of a human MAIT TCR in complex with bovine MR1===

-	~~The entry~~ 4iiq is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4iiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIQ OCA].
-	~~Authors~~: Lopez-Sagaseta, J.~~, Adams, E.J.~~	+	[[Category: Bos taurus]]
-		+	[[Category: Homo sapiens]]
-	~~Description~~:	+	[[Category: Adams, E J.]]
		+	[[Category: Lopez-Sagaseta, J.]]
		+	[[Category: Antigen presentation]]
		+	[[Category: Antigen recognition]]
		+	[[Category: Cell membrane]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Mhc-class i]]

OCA at 00:47, 4 April 2013

OCA — Thu, 04 Apr 2013 00:47:21 GMT

←Older revision		Revision as of 00:47, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iiq is ON HOLD	+	The entry 4iiq is ON HOLD until Paper Publication

	Authors: Lopez-Sagaseta, J., Adams, E.J.		Authors: Lopez-Sagaseta, J., Adams, E.J.

	Description:		Description:

OCA at 13:45, 6 March 2013

OCA — Wed, 06 Mar 2013 13:45:22 GMT

←Older revision		Revision as of 13:45, 6 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iiq is ON HOLD ~~until sometime in the future~~	+	The entry 4iiq is ON HOLD

	Authors: Lopez-Sagaseta, J., Adams, E.J.		Authors: Lopez-Sagaseta, J., Adams, E.J.

	Description:		Description:

OCA at 11:10, 23 January 2013

OCA — Wed, 23 Jan 2013 11:10:38 GMT

←Older revision		Revision as of 11:10, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iiq is ON HOLD	+	The entry 4iiq is ON HOLD until sometime in the future

	Authors: Lopez-Sagaseta, J., Adams, E.J.		Authors: Lopez-Sagaseta, J., Adams, E.J.

	Description:		Description:

OCA: Protected "4iiq" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 08:59:58 GMT

Protected "4iiq" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:59, 2 January 2013